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Dabbaghmanesh, Mohammad Hossein, Rezaei, Bahare, Haghshenas, Mohammad Reza, Montazeri-Najafabady, Nima, Mohammadian Amiri, Rajeeh, Erfani, Nasrollah. (1401). CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer. سامانه مدیریت نشریات علمی, 13(3), 404-410. doi: 10.30476/mejc.2021.87469.1421
Mohammad Hossein Dabbaghmanesh; Bahare Rezaei; Mohammad Reza Haghshenas; Nima Montazeri-Najafabady; Rajeeh Mohammadian Amiri; Nasrollah Erfani. "CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer". سامانه مدیریت نشریات علمی, 13, 3, 1401, 404-410. doi: 10.30476/mejc.2021.87469.1421
Dabbaghmanesh, Mohammad Hossein, Rezaei, Bahare, Haghshenas, Mohammad Reza, Montazeri-Najafabady, Nima, Mohammadian Amiri, Rajeeh, Erfani, Nasrollah. (1401). 'CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer', سامانه مدیریت نشریات علمی, 13(3), pp. 404-410. doi: 10.30476/mejc.2021.87469.1421
Dabbaghmanesh, Mohammad Hossein, Rezaei, Bahare, Haghshenas, Mohammad Reza, Montazeri-Najafabady, Nima, Mohammadian Amiri, Rajeeh, Erfani, Nasrollah. CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer. سامانه مدیریت نشریات علمی, 1401; 13(3): 404-410. doi: 10.30476/mejc.2021.87469.1421

CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer

Middle East Journal of Cancer
مقاله 3، دوره 13، شماره 3 - شماره پیاپی 51، مهر 2022، صفحه 404-410    اصل مقاله (393.09 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.87469.1421
نویسندگان
Mohammad Hossein Dabbaghmanesh1؛ Bahare Rezaei2؛ Mohammad Reza Haghshenas2؛ Nima Montazeri-Najafabady1؛ Rajeeh Mohammadian Amiri1؛ Nasrollah Erfani* 2، 3
1Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The aim of this study was to investigate the association between thyroid cancer and 16C/A single nucleotide polymorphism (SNP) in C-C motif chemokine 22 (CCL22) as well as 1014C/T SNP in C-C chemokine receptor type 4 (CCR4).
Method: In this case-control study, polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) was performed for 113 thyroid cancer patients and 112 age-sex matched healthy controls to investigate the genotype distribution.
Results: At position 16C/A in CCL22, 95 patients (84.3%) were found to have CC genotype, while 17 individuals (14.8%) inherited CA genotype and 1 (0.9%) had AA genotype. In the control group, 92 volunteers (82.1%) inherited CC genotype, 18 individuals (16.1%) had CA genotype, and 2 (1.8%) had AA genotype. The frequency of CC, CT, and TT genotypes of 1014C/T SNP in CCR4 gene was 60 (53.1%), 43 (38.1%), and 10 (8.8%) in the patients, and 57 (53.3%), 43 (40.2%), and 7 (6.5%) in the control group, respectively. There were no statistically significant differences between the patients and controls in terms of 16C/A polymorphism in CCL22 (P = 0.816) and 1014C/T SNP in CCR4 1014C/T gene position (P = 0.801). Nevertheless, the study of their association indicated that inheriting the CC genotype of CCR4 was significantly associated with higher stages (stages 3 and 4) in thyroid cancer.
Conclusion: 1014C/T genetic variation in CCR4 and 16C/A polymorphism in CCL22 were not found to have a role in genetic susceptibility to thyroid cancer. Inheriting CC genotype at 1014 locus in CCR4 may; however, affect cancer progression in patients with thyroid cancer.
کلیدواژه‌ها
CC chemokine receptor 4؛ CCL22 chemokine؛ Genetic variations؛ Single nucleotide polymorphism؛ Thyroid cancer؛ Cancer progression
اصل مقاله

How to cite this article:

Dabbaghmanesh MH, Rezaei B, Haghshenas MR, Montazeri-Najafabady N, Mohammadian Amiri R, Erfani N. CCR4 1014C/T and CCL22 16C/A genetic variations in Iranian patients with thyroid cancer. Middle East J Cancer. 2022;13(3):404-10. doi: 10.30476/mejc.2021.87469.1421.

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