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Chakrabarti, Tulika, Mukhopadhyay, Sibabrata, Chakrabarti, Prasun, Hatam, Gholamreza, Nami, Mohammad. (1400). Phenyl Ethanoid Glycoside from the Bark of Oroxylum indicum Vent: a Potential Inhibitor of DNA Topoisomerase IB of Leishmania donovani. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/jamsat.2021.91626.1022
Tulika Chakrabarti; Sibabrata Mukhopadhyay; Prasun Chakrabarti; Gholamreza Hatam; Mohammad Nami. "Phenyl Ethanoid Glycoside from the Bark of Oroxylum indicum Vent: a Potential Inhibitor of DNA Topoisomerase IB of Leishmania donovani". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.30476/jamsat.2021.91626.1022
Chakrabarti, Tulika, Mukhopadhyay, Sibabrata, Chakrabarti, Prasun, Hatam, Gholamreza, Nami, Mohammad. (1400). 'Phenyl Ethanoid Glycoside from the Bark of Oroxylum indicum Vent: a Potential Inhibitor of DNA Topoisomerase IB of Leishmania donovani', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/jamsat.2021.91626.1022
Chakrabarti, Tulika, Mukhopadhyay, Sibabrata, Chakrabarti, Prasun, Hatam, Gholamreza, Nami, Mohammad. Phenyl Ethanoid Glycoside from the Bark of Oroxylum indicum Vent: a Potential Inhibitor of DNA Topoisomerase IB of Leishmania donovani. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.30476/jamsat.2021.91626.1022

Phenyl Ethanoid Glycoside from the Bark of Oroxylum indicum Vent: a Potential Inhibitor of DNA Topoisomerase IB of Leishmania donovani

Journal of Advanced Medical Sciences and Applied Technologies
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 خرداد 1400
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/jamsat.2021.91626.1022
نویسندگان
Tulika Chakrabarti1؛ Sibabrata Mukhopadhyay2؛ Prasun Chakrabarti3؛ Gholamreza Hatam4؛ Mohammad Nami* 5
1Department of Chemistry, Sir Padmapat Singhania University, Udaipur-313601, Rajasthan, India
2Former Deputy Director and Scientist G, Indian Institute of Chemical Biology, lndia
3Provost, Techno India NJR Institute of Technology, Udaipur-313003, Rajasthan, India
4School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences
5Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz
چکیده
Though the Leishmania donovani complex species are morphologically indistinguishable, they can be differentiated by isoenzyme analysis, molecular methods, or monoclonal antibodies. Investigating the potential novel therapies against L. donovani has captivated research in the field of parasitology and biochemical pharmacy. In that vein, Phytochemical investigation of stem bark of Oroxylum indicum has resulted in the isolation of an interesting phenylethanoid glycoside 2-(3,4-dihydroxyphenyl)ethyl-O-α-L-rhamno-pyranosyl(1→3)-4-O-caffeoyl-β-D-glucopyranoside, first time isolated from this plant, along with two known flavone glycosides and three known flavones. The phenylethanoid glycoside was found to be a potent inhibitor of Leishmania Donovani through inhibition of LdDNA topoisomerase IB. Further research need to shed further light into the present topic.
کلیدواژه‌ها
phenyl ethanoid glycoside؛ HMBC؛ DNA topoisomerase IB؛ plasmid relaxation
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