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Fooladi, Masoomeh, Cheki, Mohsen, Shirazi, Alireza, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, Ghahramani, Fatemeh, Khoobi, Mehdi. (1401). Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury. سامانه مدیریت نشریات علمی, 12(3), 277-284. doi: 10.31661/jbpe.v0i0.2012-1243
Masoomeh Fooladi; Mohsen Cheki; Alireza Shirazi; Peyman Sheikhzadeh; Mahsa Amirrashedi; Fatemeh Ghahramani; Mehdi Khoobi. "Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury". سامانه مدیریت نشریات علمی, 12, 3, 1401, 277-284. doi: 10.31661/jbpe.v0i0.2012-1243
Fooladi, Masoomeh, Cheki, Mohsen, Shirazi, Alireza, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, Ghahramani, Fatemeh, Khoobi, Mehdi. (1401). 'Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury', سامانه مدیریت نشریات علمی, 12(3), pp. 277-284. doi: 10.31661/jbpe.v0i0.2012-1243
Fooladi, Masoomeh, Cheki, Mohsen, Shirazi, Alireza, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, Ghahramani, Fatemeh, Khoobi, Mehdi. Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury. سامانه مدیریت نشریات علمی, 1401; 12(3): 277-284. doi: 10.31661/jbpe.v0i0.2012-1243

Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury

Journal of Biomedical Physics and Engineering
مقاله 7، دوره 12، شماره 3، شهریور 2022، صفحه 277-284    اصل مقاله (1.13 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2012-1243
نویسندگان
Masoomeh Fooladi1؛ Mohsen Cheki2؛ Alireza Shirazi1؛ Peyman Sheikhzadeh3؛ Mahsa Amirrashedi1، 4؛ Fatemeh Ghahramani5؛ Mehdi Khoobi* 6، 7
1PhD Candidate, Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2PhD, Department of Medical Imaging and Radiation Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3PhD, Department of Nuclear Medicine, Imam khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran
4PhD Candidate, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
5MSc, Radiotherapy-Oncology Center, Yas Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6PhD, Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
7PhD, Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Radiation-induced hematopoietic suppression and myelotoxicity can occur due to the nuclear accidents, occupational irradiation and therapeutic interventions. Bone marrow dysfunction has always been one of the most important causes of morbidity and mortality after ionizing irradiation.
Objective: This study aims to investigate the protective effect of telmisartan against radiation-induced bone marrow injuries in a Balb/c mouse model.
Material and Methods: In this experimental study, male Balb/c mice were divided into four groups as follow: group 1: mice received phosphate buffered saline (PBS) without irradiation, group 2: mice received a solution of telmisartan in PBS without irradiation, group 3: mice received PBS with irradiation, and group 4: mice received a solution of telmisartan in PBS with irradiation. A solution of telmisartan was prepared and administered orally at 12 mg/kg body weight for seven consecutive days prior to whole body exposing to a single sub-lethal dose of 5 Gy X-rays. Protection of bone marrow against radiation induced damage was investigated by Hematoxylin-Eosin (HE) staining assay at 3, 9, 15 and 30 days after irradiation.
Results: Histopathological analysis indicated that administration of telmisartan reduced X-radiation-induced damage and improved bone marrow histology. The number of different cell types in bone marrow, including polymorphonuclear /mononuclear cells and megakaryocytes significantly increased in telmisartan treated group compared to the only irradiated group at all-time points.
Conclusion: The results of the present study demonstrated an efficient radioprotective effect of telmisartan in mouse bone marrow against sub-lethal X-irradiation.
کلیدواژه‌ها
Radiation؛ Ionizing؛ Radioprotector؛ Bone Marrow؛ Telmisartan
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