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Fooladi, Masoomeh, Cheki, Mohsen, Shirazi, Alireza, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, Ghahramani, Fatemeh, Khoobi, Mehdi. (1401). Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury. سامانه مدیریت نشریات علمی, 12(3), 277-284. doi: 10.31661/jbpe.v0i0.2012-1243
Masoomeh Fooladi; Mohsen Cheki; Alireza Shirazi; Peyman Sheikhzadeh; Mahsa Amirrashedi; Fatemeh Ghahramani; Mehdi Khoobi. "Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury". سامانه مدیریت نشریات علمی, 12, 3, 1401, 277-284. doi: 10.31661/jbpe.v0i0.2012-1243
Fooladi, Masoomeh, Cheki, Mohsen, Shirazi, Alireza, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, Ghahramani, Fatemeh, Khoobi, Mehdi. (1401). 'Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury', سامانه مدیریت نشریات علمی, 12(3), pp. 277-284. doi: 10.31661/jbpe.v0i0.2012-1243
Fooladi, Masoomeh, Cheki, Mohsen, Shirazi, Alireza, Sheikhzadeh, Peyman, Amirrashedi, Mahsa, Ghahramani, Fatemeh, Khoobi, Mehdi. Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury. سامانه مدیریت نشریات علمی, 1401; 12(3): 277-284. doi: 10.31661/jbpe.v0i0.2012-1243

Histopathological Evaluation of Protective Effect of Telmisartan against Radiation-Induced Bone Marrow Injury

Journal of Biomedical Physics and Engineering
مقاله 7، دوره 12، شماره 3، مرداد و شهریور 2022، صفحه 277-284    اصل مقاله (1.13 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2012-1243
نویسندگان
Masoomeh Fooladi1؛ Mohsen Cheki2؛ Alireza Shirazi1؛ Peyman Sheikhzadeh3؛ Mahsa Amirrashedi1، 4؛ Fatemeh Ghahramani5؛ Mehdi Khoobi* 6، 7
1PhD Candidate, Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2PhD, Department of Medical Imaging and Radiation Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3PhD, Department of Nuclear Medicine, Imam khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran
4PhD Candidate, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
5MSc, Radiotherapy-Oncology Center, Yas Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6PhD, Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
7PhD, Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Radiation-induced hematopoietic suppression and myelotoxicity can occur due to the nuclear accidents, occupational irradiation and therapeutic interventions. Bone marrow dysfunction has always been one of the most important causes of morbidity and mortality after ionizing irradiation.
Objective: This study aims to investigate the protective effect of telmisartan against radiation-induced bone marrow injuries in a Balb/c mouse model.
Material and Methods: In this experimental study, male Balb/c mice were divided into four groups as follow: group 1: mice received phosphate buffered saline (PBS) without irradiation, group 2: mice received a solution of telmisartan in PBS without irradiation, group 3: mice received PBS with irradiation, and group 4: mice received a solution of telmisartan in PBS with irradiation. A solution of telmisartan was prepared and administered orally at 12 mg/kg body weight for seven consecutive days prior to whole body exposing to a single sub-lethal dose of 5 Gy X-rays. Protection of bone marrow against radiation induced damage was investigated by Hematoxylin-Eosin (HE) staining assay at 3, 9, 15 and 30 days after irradiation.
Results: Histopathological analysis indicated that administration of telmisartan reduced X-radiation-induced damage and improved bone marrow histology. The number of different cell types in bone marrow, including polymorphonuclear /mononuclear cells and megakaryocytes significantly increased in telmisartan treated group compared to the only irradiated group at all-time points.
Conclusion: The results of the present study demonstrated an efficient radioprotective effect of telmisartan in mouse bone marrow against sub-lethal X-irradiation.
کلیدواژه‌ها
Radiation؛ Ionizing؛ Radioprotector؛ Bone Marrow؛ Telmisartan
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مراجع
  1. Xiao M, Whitnall MH. Pharmacological countermeasures for the acute radiation syndrome. Curr Mol Pharmacol. 2009;2(1):122-33. doi: 10.2174/1874467210902010122. PubMed PMID: 20021452.
  2. Ko S, Chung HH, Cho SB, Jin YW, et al. Occupational radiation exposure and its health effects on interventional medical workers: study protocol for a prospective cohort study. BMJ Open. 2017;7(12):e018333. doi: 10.1136/bmjopen-2017-018333. PubMed PMID: 29248885. PubMed PMCID: PMC5778344.
  3. Calvi LM, Frisch BJ, Kingsley PD, et al. Acute and late effects of combined internal and external radiation exposures on the hematopoietic system. Int J Radiat Biol. 2019;95(11):1447-61. doi: 10.1080/09553002.2019.1644932. PubMed PMID: 31329495.
  4. López M, Martín M. Medical management of the acute radiation syndrome. Reports Pract Oncol Radiother. 2011;16(4):138-46. doi: 10.1016/j.rpor.2011.05.001. PubMed PMID: 24376971. PubMed PMCID: PMC3863169.
  5. Zhang X, Xing X, Liu H, Feng J, et al. Ionizing radiation induces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow. Int J Radiat Biol. 2020;96(5):584-95. doi: 10.1080/09553002.2020.1708993. PubMed PMID: 31906761.
  6. Kamran MZ, Ranjan A, Kaur N, Sur S, Tandon V. Radioprotective agents: strategies and translational advances. Med Res Rev. 2016;36(3):461-93. doi: 10.1002/med.21386. PubMed PMID: 26807693.
  7. Mun G-I, Kim S, Choi E, Kim CS, Lee Y-S. Pharmacology of natural radioprotectors. Arch Pharm Res. 2018;41(11):1033-50. doi: 10.1007/s12272-018-1083-6. PubMed PMID: 30361949. PubMed PMCID: PMC6224001.
  8. Davis TA, Landauer MR, Mog SR, et al. Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Exp Hematol. 2010;38(4):270-81. doi: 10.1016/j.exphem.2010.01.004. PubMed PMID: 20116413. PubMed PMCID: PMC2843794.
  9. Moulder J, Fish B, Cohen E. Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists. Curr Pharm Des. 2007;13(13):1317-25. doi: 10.2174/138161207780618821. PubMed PMID: 17506717.
  10. Medhora M, Gao F, Jacobs ER, Moulder JE. Radiation damage to the lung: Mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology. 2012;17(1):66-71. doi: 10.1111/j.1440-1843.2011.02092.x. PubMed PMID: 22023053. PubMed PMCID: PMC3245332.
  11. Yusuf S, Diener H-C, Sacco RL, et al. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008;359(12):1225-37. doi: 10.1056/NEJMoa0804593. PubMed PMID: 18753639. PubMed PMCID: PMC2714258.
  12. Al-Hejjaj WK, Numan IT, Al-Sa’ad RZ, Hussain SA. Anti-inflammatory activity of telmisartan in rat models of experimentally-induced chronic inflammation: Comparative study with dexamethasone. Saudi Pharm J. 2011;19(1):29-34. doi: 10.1016/j.jsps.2010.10.004. PubMed PMID: 23960739. PubMed PMCID: PMC3745173.
  13. Goyal S, Bharti S, Bhatia J, et al. Telmisartan, a dual ARB/partial PPAR-γ agonist, protects myocardium from ischaemic reperfusion injury in experimental diabetes. Diabetes, Obes Metab. 2011;13(6):533-41. doi: 10.1111/j.1463-1326.2011.01377.x. PubMed PMID: 21320264.
  14. Eslami H, Sharifi AM, Rahimi H, Rahati M. Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell. Neurosci Lett. 2014;558:31-6. doi: 10.1016/j.neulet.2013.10.057. PubMed PMID: 24211690.
  15. Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today. 2007;12(19-20):794-805. doi: 10.1016/j.drudis.2007.07.017. PubMed PMID: 17933679.
  16. Remuzzi A, Remuzzi G. Potential protective effects of telmisartan on renal function deterioration. J Renin-Angiotensin-Aldosterone Syst. 2006;7(4):185-91. doi: 10.3317/jraas.2006.036. PubMed PMID: 17318786.
  17. Abraham HMA, White CM, White WB. The comparative efficacy and safety of the angiotensin receptor blockers in the management of hypertension and other cardiovascular diseases. Drug Saf. 2015;38(1):33-54. doi: 10.1007/s40264-014-0239-7. PubMed PMID: 25416320. PubMed PMCID: PMC4303500.
  18. Suman S, Maniar M, Fornace AJ, Datta K. Administration of ON 01210. Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. Radiat Oncol. 2012;7(1):1-9. doi: 10.1186/1748-717X-7-6. PubMed PMID: 22264334. PubMed PMCID: PMC3275448.
  19. Vaupel D, McCoun D, Cone EJ. Phencyclidine analogs and precursors: rotarod and lethal dose studies in the mouse. J Pharmacol Exp Ther. 1984;230(1):20-7. PubMed PMID: 6747825.
  20. Underwood W, Anthony R. AVMA Guidelines for the Euthanasia of Animals: 2020 Edition. The American Veterinary Medical Association (AVMA); 2020.
  21. Zhang C, Lin J, Cui J, Li B, et al. Radioprotection of bone marrow hematopoiesis by CpG-oligodeoxynucleotides administered to mice after total-body irradiation. J Radiat Res. 2011;52(6):828-33. doi: 10.1269/jrr.10098. PubMed PMID: 22104272.
  22. Lu X, Nurmemet D, Bolduc DL, et al. Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine. Cell Biosci. 2013;3(1):1-16. doi: 10.1186/2045-3701-3-36. PubMed PMID: 24499553. PubMed PMCID: PMC3852109.
  23. Zhang P, Du J, Zhao H, Cheng Y, et al. Radioprotective effects of roxadustat (FG-4592) in haematopoietic system. J Cell Mol Med. 2019;23(1):349-56. doi: 10.1111/jcmm.13937.
  24. Sato T, Kinoshita M, Yamamoto T, Ito M, et al. Treatment of irradiated mice with high-dose ascorbic acid reduced lethality. PLoS One. 2015;10(2):e0117020. doi: 10.1371/journal.pone.0117020. PubMed PMID: 25651298. PubMed PMCID: PMC4317183.
  25. Li D, Tian Z, Tang W, Zhang J, Lu L, Sun Z, et al. The protective effects of 5-methoxytryptamine-α-lipoic acid on ionizing radiation-induced hematopoietic injury. Int J Mol Sci. 2016;17(6):935. doi: 10.3390/ijms17060935. PubMed PMID: 27314327. PubMed PMCID: PMC4926468.
  26. Simonnet AJ, Nehmé J, Vaigot P, Barroca V, et al. Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure. Stem Cells. 2009;27(6):1400-9. doi: 10.1002/stem.66. PubMed PMID: 19489102.
  27. Dong L, Yang Y, Lu Y, Lu C, Lv J, Jiang N, et al. Radioprotective effects of dammarane sapogenins against 60Co-induced myelosuppression in mice. Phyther Res. 2018;32(4):741-9. doi: 10.1002/ptr.6027. PubMed PMID: 29356175.
  28. Zhao L, Wang Y, Shen H-l, Shen X-d, et al. Structural characterization and radioprotection of bone marrow hematopoiesis of two novel polysaccharides from the root of Angelica sinensis (Oliv.) Diels. Fitoterapia. 2012;83(8):1712-20. doi: 10.1016/j.fitote.2012.09.029. PubMed PMID: 23063893.
  29. Li XH, Fu D, Latif NH, Mullaney CP, Ney PH, Mog SR, et al. δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Haematologica. 2010;95(12):1996-2004. doi: 10.3324/haematol.2010.026492. PubMed PMID: 20823133. PubMed PMCID: PMC2995556.
  30. Davis TA, Clarke TK, Mog SR, Landauer MR. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol. 2007;83(3):141-51. doi: 10.1080/09553000601132642. PubMed PMID: 17378522.
  31. Cristina Schwarz F, Da Silva Mansano N, Bruno Chies A, et al. Potential Radioprotective Effect of AT 1 Receptor Antagonists Against Morphological and Ultrastructural Changes in the Testes Induced by Ionizing Radiation. Int J Morphol. 2017;35(3):820-30. doi: 10.4067/S0717-95022017000300005.
  32. Da Silva Mansano N, Jorge IF, Chies AB, et al. Effects of telmisartan and losartan on irradiated testes. Life Sci. 2018;194:157-67. doi: 10.1016/j.lfs.2017.12.031. PubMed PMID: 29287783.
  33. Cavalim Vale AP, Dos Santos G, Da Silva, et al. Influence of the AT1 Receptor Antagonists Telmisartan and Losartan on Reproduction and Offspring After Paternal Exposure to Ionizing Radiation. Reprod Sci. 2019;26(5):639-48. doi: 10.1177/1933719118783251. PubMed PMID: 29938606.
  34. Charrier S, Michaud A, Badaoui S, et al. Inhibition of angiotensin I–converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells. Blood. 2004;104(4):978-85. doi: 10.1182/blood-2003-11-3828. PubMed PMID: 15105290.
  35. Liu J-M, Lawrence F, Kovacevic M, Bignon J, et al. The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood, J Am Soc Hematol. 2003;101(8):3014-20. doi: 10.1182/blood-2002-07-2315. PubMed PMID: 12480715.
  36. Haznedaroglu IC, Öztürk MA. Towards the understanding of the local hematopoietic bone marrow renin-angiotensin system. Int J Biochem Cell Biol. 2003;35(6):867-80. doi: 10.1016/S1357-2725(02)00278-9. PubMed PMID: 12676173.
  37. Hubert C, Savary K, Gasc J-M, Corvol P. The hematopoietic system: a new niche for the renin–angiotensin system. Nat Clin Pract Cardiovasc Med. 2006;3(2):80-5. doi: 10.1038/ncpcardio0449. PubMed PMID: 16446776.
  38. Arab HH, Al-Shorbagy MY, Abdallah DM, Nassar NN. Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease. PloS One. 2014;9(5):e97193. doi: 10.1371/journal.pone.0097193. PubMed PMID: 24831514. PubMed PMCID: PMC4022743.
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