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Mohamed, Salem, Hafez, Abeer, Elwan, Amira, Abdelhamid, Mohamed, Ahmed, Nabila, Abdelmaksoud, Bader, Abdelbary, Abeer. (1400). Prognostic Value of IMP3 and Cyclin D1 Expression in Patients with Colorectal Cancer. سامانه مدیریت نشریات علمی, 13(1), 57-66. doi: 10.30476/mejc.2021.85085.1258
Salem Youssef Mohamed; Abeer Hafez; Amira Elwan; Mohamed I. Abdelhamid; Nabila Hassan Ahmed; Bader A. Abdelmaksoud; Abeer M Abdelbary. "Prognostic Value of IMP3 and Cyclin D1 Expression in Patients with Colorectal Cancer". سامانه مدیریت نشریات علمی, 13, 1, 1400, 57-66. doi: 10.30476/mejc.2021.85085.1258
Mohamed, Salem, Hafez, Abeer, Elwan, Amira, Abdelhamid, Mohamed, Ahmed, Nabila, Abdelmaksoud, Bader, Abdelbary, Abeer. (1400). 'Prognostic Value of IMP3 and Cyclin D1 Expression in Patients with Colorectal Cancer', سامانه مدیریت نشریات علمی, 13(1), pp. 57-66. doi: 10.30476/mejc.2021.85085.1258
Mohamed, Salem, Hafez, Abeer, Elwan, Amira, Abdelhamid, Mohamed, Ahmed, Nabila, Abdelmaksoud, Bader, Abdelbary, Abeer. Prognostic Value of IMP3 and Cyclin D1 Expression in Patients with Colorectal Cancer. سامانه مدیریت نشریات علمی, 1400; 13(1): 57-66. doi: 10.30476/mejc.2021.85085.1258

Prognostic Value of IMP3 and Cyclin D1 Expression in Patients with Colorectal Cancer

Middle East Journal of Cancer
مقاله 6، دوره 13، شماره 1 - شماره پیاپی 49، فروردین 2022، صفحه 57-66    اصل مقاله (2.55 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.85085.1258
نویسندگان
Salem Youssef Mohamed* 1؛ Abeer Hafez2؛ Amira Elwan3؛ Mohamed I. Abdelhamid4؛ Nabila Hassan Ahmed5؛ Bader A. Abdelmaksoud3؛ Abeer M Abdelbary2
1Gastroenterology and Hepatology Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Clinical Oncology Department, Zagazig University, Zagazig, Egypt
4General Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5Tropical Medicine Department, Zagazig University, Zagazig, Egypt
چکیده
Background: Colorectal cancer (CRC) is known to be the third most frequently diagnosed cancer and the fourth leading cause of cancer death worldwide. In Egypt, colorectal carcinoma is considered the 7th prevalent cancer, accounting for 3.47% of male cancers and 3% of female malignancies. A localized CRC can be entirely cured via surgical resection. Metastasis remains the leading cause of cancer mortality. IMP3 is an independent prognostic biomarker that expects metastasis and poor prognosis in CRC. The upregulation of nuclear cyclin D1 plays an essential role in pathogenesis and metastases of CRC. We aimed to investigate the expression of IMP3 and cyclin D1 in colorectal carcinoma and their correlation with other clinicopathological features.
Method: In this retrospective cohort study, 80 formalin-fixed and paraffin-embedded blocks of CRC were obtained from the subjects. The immunohistochemical expression of IMP3 and cyclin D1 were examined and found to be correlated with clinical-pathological parameters and the outcome of the patients.
Results: Overexpression of IMP3 and cyclin D1 was noted in 68.75% and 56.25%, respectively. IMP3 expression was significantly correlated with tumor grade (P < 0.001), tumor, node, and metastases (TNM) stage (P = 0.040), and lymphovascular invasion (P = 0.005); cyclin D1 was significantly associated with TNM stage (P < 0.001), lymph node (LN) metastasis (P < 0.001), and distant metastasis (DM) (P = 0.004); cyclin D1 was significantly correlated with TNM stage (P < 0.001), LN metastasis (P < 0.001), and DM (P = 0.004).
Conclusion: IMP3 and cyclin d1 were associated with poor prognosis in CRC, w hich makes them attractive targets for anticancer drug development.
کلیدواژه‌ها
IMP3؛ Cyclin D1؛ Colorectal cancer؛ Recurrence؛ Survival
اصل مقاله

How to cite this article:

Mohamed SY, Hafez A, Elwan A, Abdelhamid MI, Ahmed NH, Abdelmaksoud BA, et al. Prognostic value of IMP3 and cyclin D1 expression in patients with colorectal cancer. Middle East J Cancer. 2022;13(1):57-66. doi: 10.30476/mejc.2021. 85085.1258.

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