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Koohpeyma, Farhad, Ranjbar Omrani, Gholamhossein, Zamani, Ali, Saki, Forough. (1400). Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats. سامانه مدیریت نشریات علمی, 46(6), 468-474. doi: 10.30476/ijms.2020.85368.1503
Farhad Koohpeyma; Gholamhossein Ranjbar Omrani; Ali Zamani; Forough Saki. "Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats". سامانه مدیریت نشریات علمی, 46, 6, 1400, 468-474. doi: 10.30476/ijms.2020.85368.1503
Koohpeyma, Farhad, Ranjbar Omrani, Gholamhossein, Zamani, Ali, Saki, Forough. (1400). 'Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats', سامانه مدیریت نشریات علمی, 46(6), pp. 468-474. doi: 10.30476/ijms.2020.85368.1503
Koohpeyma, Farhad, Ranjbar Omrani, Gholamhossein, Zamani, Ali, Saki, Forough. Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats. سامانه مدیریت نشریات علمی, 1400; 46(6): 468-474. doi: 10.30476/ijms.2020.85368.1503

Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats

Iranian Journal of Medical Sciences
مقاله 7، دوره 46، شماره 6، بهمن 2021، صفحه 468-474    اصل مقاله (1.37 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.85368.1503
نویسندگان
Farhad Koohpeyma؛ Gholamhossein Ranjbar Omrani؛ Ali Zamani؛ Forough Saki*
Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Paricalcitol has been proposed for the treatment of secondary hyperparathyroidism in patients with renal failure and vitamin D deficiency (VDD); however, VDD is related to a range of clinical complaints. We aimed to investigate the effects of paricalcitol on body composition in VDD rats.
Methods: Thirty adult male rats aged 10 weeks were randomly divided into three groups of 10, comprising control, VDD, and VDD plus paricalcitol (32 ng/rat intraperitoneal injection) (VDD+P), at the Animal Lab of the Endocrinology and Metabolism Research Center, Shiraz, Iran, in 2020. Body composition was assessed after three weeks via serum biochemical tests and dual-energy X-ray absorptiometry. Finally, the data were analyzed by using the paired-sample t test, the one-way ANOVA, and the Tukey post hoc test.
Results: Global lean mass and fat mass were lower in the VDD and VDD+P groups than in the controls (p <0.001). Global fat percentage was reduced significantly in the VDD+P group (P=0.029).
Conclusion: Paricalcitol reduced global fat mass and fat percentage in a rat model with VDD. Evaluation of insulin and adiponectin levels is suggested to clarify the physiology of paricalcitol in VDD states.
کلیدواژه‌ها
Body composition؛ Vitamin D؛ Calcium؛ Rats
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مراجع
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