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Sadeghi, Afsaneh, Razavi, Seyed Sajad, Eghbali, Ahmad, Mahdavi, Seyed Alireza, Kimia, Fereshteh, Panah, Ashkan. (1400). The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 47(1), 25-32. doi: 10.30476/ijms.2020.84509.1471
Afsaneh Sadeghi; Seyed Sajad Razavi; Ahmad Eghbali; Seyed Alireza Mahdavi; Fereshteh Kimia; Ashkan Panah. "The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 47, 1, 1400, 25-32. doi: 10.30476/ijms.2020.84509.1471
Sadeghi, Afsaneh, Razavi, Seyed Sajad, Eghbali, Ahmad, Mahdavi, Seyed Alireza, Kimia, Fereshteh, Panah, Ashkan. (1400). 'The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 47(1), pp. 25-32. doi: 10.30476/ijms.2020.84509.1471
Sadeghi, Afsaneh, Razavi, Seyed Sajad, Eghbali, Ahmad, Mahdavi, Seyed Alireza, Kimia, Fereshteh, Panah, Ashkan. The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1400; 47(1): 25-32. doi: 10.30476/ijms.2020.84509.1471

The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 4، دوره 47، شماره 1، فروردین 2022، صفحه 25-32    اصل مقاله (321.22 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.84509.1471
نویسندگان
Afsaneh Sadeghi1؛ Seyed Sajad Razavi1؛ Ahmad Eghbali1؛ Seyed Alireza Mahdavi1؛ Fereshteh Kimia1؛ Ashkan Panah* 2
1Anesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Emergence Agitation (EA) is a dissociated state of consciousness characterized by irritability, uncompromising stance, and inconsolability. The etiology of EA is not completely understood. Dexmedetomidine is a highly selective α2-adrenoreceptor agonist with sedative and analgesic properties, which has been used to reduce the incidence of EA. We aimed to assess the efficacy of early versus late administration of dexmedetomidine on EA in children undergoing oral surgery.
Methods: A randomized, parallel, double-blind clinical trial was conducted at Mofid Children’s Hospital affiliated to Shahid Beheshti University of Medical Sciences (Tehran, Iran) from November 2016 to March 2017. A total of 81 children, who underwent adenotonsillectomy or cleft palate repair surgery were enrolled in the study. Based on simple randomization, the children were assigned to two groups, namely early (group A, n=41) and late (group B, n=40) administration of dexmedetomidine. Intra-operative and postoperative hemodynamic variables, extubation time, post-anesthesia care unit (PACU) length of stay, and the scores on Ramsay sedation scale and FLACC pain scale were measured and compared. The data were analyzed using SPSS software (version 20.0), and p Results: The mean FLACC score was lower in the late group than in the early group (2.0±1.5 vs. 4.2±1.6, p <0.001). The mean Ramsay sedation score was higher in the late group than in the early group (3.5±1.4 vs. 1.8±0.8, p <0.001).
Conclusion: Late administration of dexmedetomidine 1 µg/kg reduced the incidence of EA and PACU length of stay and improved postoperative pain management.
Trial registration number: IRCT 2016122031497N1.
کلیدواژه‌ها
Delayed emergence from anesthesia؛ Emergence delirium؛ Dexmedetomidine؛ Cleft palate؛ Tonsillectomy
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مراجع
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