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Prevalence of Anti-SARS-CoV-2 Specific Antibodies in Health-Care Workers Compared to General Population during an Early Phase of the Pandemic, Tehran-Iran | ||
Iranian Journal of Immunology | ||
دوره 18، شماره 1، خرداد 2021، صفحه 82-92 اصل مقاله (502.8 K) | ||
نوع مقاله: Original Article | ||
شناسه دیجیتال (DOI): 10.22034/iji.2021.88168.1851 | ||
نویسندگان | ||
Sahar Mortezagholi1؛ Davood Rostamzadeh2؛ Maedeh Alinejad1؛ Vahid Younesi3؛ Payam Tabarsi4؛ Mahdi Shabani* 5 | ||
1Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran | ||
3Synapse IVD accelerator, Tehran, Iran | ||
4Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, ShahidBeheshti University of Medical Sciences, Tehran, Iran. | ||
5Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, | ||
چکیده | ||
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly transmits in general population, mainly between health-care workers (HCWs) who are in close contact with patients. Objective: To study the seropositivity of HCWs as a high-risk group compared to general population. Methods: 72 samples were obtained from HCWs working in Masih Daneshvari hospital as one of the main COVID-19 admission centers in Tehran, during April 4 to 6, 2020. Also we collected 2021 blood samples from general population. The SARS-CoV-2 specific IgM, and IgG antibodies in the collected serum specimens were measured by commercial ELISA kits. Results: Based on the clinical manifestations, 25.0%, 47.2%, and 27.8% of HCWs were categorized as symptomatic with typical symptoms, symptomatic with atypical symptoms, and asymptomatic, respectively. Symptomatic individuals with typical and atypical symptoms were 63.2% and 36.8% positive in RT-PCR test, respectively. Anti-SARS-CoV-2 IgM and IgG antibodies were detected in 15.3% and 27.8% of HCWs samples, respectively. Antibody testing in the general population indicated that SARS-CoV-2 specific IgM and IgG were found in (162/2021) 8%, and (290/2021) 14.4%, respectively. The frequency of positive cases of IgM and IgG were significantly increased in HCWs compared to general population (p= 0.028 for IgM and p= 0.002 for IgG). Conclusion: The frequency of SARS-CoV-2 specific antibodies in HCWs was higher than general population indicating a higher viral transmission via close exposure with COVID-19 patients. | ||
کلیدواژهها | ||
COVID-19؛ ELISA؛ General Population؛ Health-Care Workers؛ SARS-CoV-2؛ Seroprevalence | ||
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