LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,093
تعداد مقالات10,030
تعداد مشاهده مقاله27,412,729
تعداد دریافت فایل اصل مقاله7,567,583
Hassani, Danesh, Amiri, Mohammad Mehdi, Maghsood, Faezeh, Salimi, Vahid, Kardar, Gholam Ali, Barati, Omid, Hashemian, Seyed Mohammad Reza, Jeddi-Tehrani, Mahmood, Zarnani, Amir-Hassan, Shokri, Fazel. (1399). Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?. سامانه مدیریت نشریات علمی, 18(1), 47-53. doi: 10.22034/iji.2021.87990.1843
Danesh Hassani; Mohammad Mehdi Amiri; Faezeh Maghsood; Vahid Salimi; Gholam Ali Kardar; Omid Barati; Seyed Mohammad Reza Hashemian; Mahmood Jeddi-Tehrani; Amir-Hassan Zarnani; Fazel Shokri. "Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?". سامانه مدیریت نشریات علمی, 18, 1, 1399, 47-53. doi: 10.22034/iji.2021.87990.1843
Hassani, Danesh, Amiri, Mohammad Mehdi, Maghsood, Faezeh, Salimi, Vahid, Kardar, Gholam Ali, Barati, Omid, Hashemian, Seyed Mohammad Reza, Jeddi-Tehrani, Mahmood, Zarnani, Amir-Hassan, Shokri, Fazel. (1399). 'Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?', سامانه مدیریت نشریات علمی, 18(1), pp. 47-53. doi: 10.22034/iji.2021.87990.1843
Hassani, Danesh, Amiri, Mohammad Mehdi, Maghsood, Faezeh, Salimi, Vahid, Kardar, Gholam Ali, Barati, Omid, Hashemian, Seyed Mohammad Reza, Jeddi-Tehrani, Mahmood, Zarnani, Amir-Hassan, Shokri, Fazel. Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?. سامانه مدیریت نشریات علمی, 1399; 18(1): 47-53. doi: 10.22034/iji.2021.87990.1843

Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?

Iranian Journal of Immunology
دوره 18، شماره 1، خرداد 2021، صفحه 47-53    اصل مقاله (485.87 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.87990.1843
نویسندگان
Danesh Hassani1؛ Mohammad Mehdi Amiri1؛ Faezeh Maghsood1؛ Vahid Salimi2؛ Gholam Ali Kardar3؛ Omid Barati4؛ Seyed Mohammad Reza Hashemian5؛ Mahmood Jeddi-Tehrani6؛ Amir-Hassan Zarnani1؛ Fazel Shokri* 1
1Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3Immunology Asthma & Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
4Health Human Resources Research Center, School of Management and Medical Informatics, Shiraz University of Medical Sciences, Shiraz, Iran
5Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
6Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
چکیده
Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. Objective: To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. Methods: The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Results: Our results revealed significant differences in anti-NP (p <0.0001) and anti-RBD (p <0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (p <0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (p <0.01). Conclusion: Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody.
کلیدواژه‌ها
Antibody response؛ Cross-Protection؛ MMR؛ SARS-CoV2؛ Tetanus
آمار
تعداد مشاهده مقاله: 1,824
تعداد دریافت فایل اصل مقاله: 910


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب