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Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens? | ||
Iranian Journal of Immunology | ||
دوره 18، شماره 1، خرداد 2021، صفحه 47-53 اصل مقاله (485.87 K) | ||
نوع مقاله: Original Article | ||
شناسه دیجیتال (DOI): 10.22034/iji.2021.87990.1843 | ||
نویسندگان | ||
Danesh Hassani1؛ Mohammad Mehdi Amiri1؛ Faezeh Maghsood1؛ Vahid Salimi2؛ Gholam Ali Kardar3؛ Omid Barati4؛ Seyed Mohammad Reza Hashemian5؛ Mahmood Jeddi-Tehrani6؛ Amir-Hassan Zarnani1؛ Fazel Shokri* 1 | ||
1Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
2Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
3Immunology Asthma & Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran | ||
4Health Human Resources Research Center, School of Management and Medical Informatics, Shiraz University of Medical Sciences, Shiraz, Iran | ||
5Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
6Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran | ||
چکیده | ||
Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. Objective: To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. Methods: The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Results: Our results revealed significant differences in anti-NP (p <0.0001) and anti-RBD (p <0.0001) IgG levels between patients and healthy controls. While the levels of rubella- and mumps specific IgG were not different in the two groups of subjects, measles-specific IgG was significantly higher in patients (p <0.01). The serum titer of anti-tetanus antibody, however, was significantly lower in patients compared to healthy individuals (p <0.01). Conclusion: Our findings suggest that measles vaccination triggers those B cells cross-reactive with SARS-CoV2 antigens leading to the production of increased levels of measles-specific antibody. | ||
کلیدواژهها | ||
Antibody response؛ Cross-Protection؛ MMR؛ SARS-CoV2؛ Tetanus | ||
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