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Mansourabadi, Amir Hossein, Sadeghalvad, Mona, Mohammadimotlagh, Hamid-Reza, Amirzargar, Aliakbar. (1399). Serological and Molecular Tests for COVID-19: a recent update. سامانه مدیریت نشریات علمی, 18(1), 13-33. doi: 10.22034/iji.2021.88660.1894
Amir Hossein Mansourabadi; Mona Sadeghalvad; Hamid-Reza Mohammadimotlagh; Aliakbar Amirzargar. "Serological and Molecular Tests for COVID-19: a recent update". سامانه مدیریت نشریات علمی, 18, 1, 1399, 13-33. doi: 10.22034/iji.2021.88660.1894
Mansourabadi, Amir Hossein, Sadeghalvad, Mona, Mohammadimotlagh, Hamid-Reza, Amirzargar, Aliakbar. (1399). 'Serological and Molecular Tests for COVID-19: a recent update', سامانه مدیریت نشریات علمی, 18(1), pp. 13-33. doi: 10.22034/iji.2021.88660.1894
Mansourabadi, Amir Hossein, Sadeghalvad, Mona, Mohammadimotlagh, Hamid-Reza, Amirzargar, Aliakbar. Serological and Molecular Tests for COVID-19: a recent update. سامانه مدیریت نشریات علمی, 1399; 18(1): 13-33. doi: 10.22034/iji.2021.88660.1894

Serological and Molecular Tests for COVID-19: a recent update

Iranian Journal of Immunology
دوره 18، شماره 1، خرداد 2021، صفحه 13-33    اصل مقاله (1.19 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.88660.1894
نویسندگان
Amir Hossein Mansourabadi1؛ Mona Sadeghalvad1؛ Hamid-Reza Mohammadimotlagh2؛ Aliakbar Amirzargar* 1
1Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
The COVID-19 pandemic is probably the most devastating worldwide challenge in recent century. COVID-19 leads to a mild to severe respiratory disease and affects different organs and has become a global concern since December 2019. Meanwhile, molecular biology and diagnostic laboratories played an essential role in diagnosis of the disease by introducing serological and molecular tests. Molecular-based techniques are reliable detection tools for SARS-CoV-2 and used for diagnosis of patients especially in the early stage of the disease. While, serological assays are considered as additional tools to verify the asymptomatic infections, tracing previous contacts of individuals, vaccine efficacy, and study the seroprevalance. The average time of the appearance of anti-SARS-CoV-2 antibodies in the patient's serum is 3-6 days after the onset of symptoms for both IgM and IgA and 10-18 days for IgG. Following the outbreak of COVID-19, FDA has approved and authorized a series of serological laboratory tests for early diagnosis. Serological assays have low-cost and provide fast results but have poor sensitivity in the early stage of the viral infection. Although the serological tests may not play an important role in the active case of COVID-19, it could be effective to determine the immunity of health care workers, and confirm late COVID-19 cases during the outbreak. In this review, we compared various laboratory diagnostic assays for COVID-19.
کلیدواژه‌ها
COVID-19؛ Laboratory Diagnosis Tests؛ PCR؛ SARS-CoV-2؛ Serological Assays
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