LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,110
تعداد دریافت فایل اصل مقاله11,291,824
Ghadimi Darsajini, Ali, Soleimani, Mohammad, Mirjani, Ruholah. (1402). The Combination of Photothermal Therapy and Chemotherapy using Alginate-Modified Iron Oxide-Gold Nanohybrids Carrying Cisplatin. سامانه مدیریت نشریات علمی, 13(2), 117-124. doi: 10.31661/jbpe.v0i0.2003-1083
Ali Ghadimi Darsajini; Mohammad Soleimani; Ruholah Mirjani. "The Combination of Photothermal Therapy and Chemotherapy using Alginate-Modified Iron Oxide-Gold Nanohybrids Carrying Cisplatin". سامانه مدیریت نشریات علمی, 13, 2, 1402, 117-124. doi: 10.31661/jbpe.v0i0.2003-1083
Ghadimi Darsajini, Ali, Soleimani, Mohammad, Mirjani, Ruholah. (1402). 'The Combination of Photothermal Therapy and Chemotherapy using Alginate-Modified Iron Oxide-Gold Nanohybrids Carrying Cisplatin', سامانه مدیریت نشریات علمی, 13(2), pp. 117-124. doi: 10.31661/jbpe.v0i0.2003-1083
Ghadimi Darsajini, Ali, Soleimani, Mohammad, Mirjani, Ruholah. The Combination of Photothermal Therapy and Chemotherapy using Alginate-Modified Iron Oxide-Gold Nanohybrids Carrying Cisplatin. سامانه مدیریت نشریات علمی, 1402; 13(2): 117-124. doi: 10.31661/jbpe.v0i0.2003-1083

The Combination of Photothermal Therapy and Chemotherapy using Alginate-Modified Iron Oxide-Gold Nanohybrids Carrying Cisplatin

Journal of Biomedical Physics and Engineering
دوره 13، شماره 2، تیر 2023، صفحه 117-124    اصل مقاله (873.29 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2003-1083
نویسندگان
Ali Ghadimi Darsajini1؛ Mohammad Soleimani* 1، 2؛ Ruholah Mirjani3
1Department of Microbiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
2Infectious Diseases Research Center, AJA University of Medical Sciences, Tehran, Iran
3Department of Genetics and Advanced Technologies, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
چکیده
Background: Chemotherapy is typically the first-line treatment for the advanced stage of cancers. However, there are shortcomings with respect to conventional chemotherapy that limit therapeutic efficiency, including lack of tumor selectivity, systemic toxicity and drug resistance. 
Objective: A multifunctional nanoplatform was build using of hydrogel co-loaded containing cisplatin and Iron oxide–gold core-shell nanoparticles. The Au shell comprises the light response and the iron core can be utilized as a negative contrast agent in nanocomplex.
Material and Methods: In this experimental study, KB cells derived from the epithelial cells located in the nasopharynx were exposed to different levels of concentration of hydrogel co-loaded with cisplatin and Iron oxide–gold core-shell nanoparticles. Afterwards, the cytotoxicity was determined using MTT assay. 
Results: The cytotoxicity results showed that this nanoplatforms has potent to create higher cytotoxicity in KB cells than free cisplatin, so that Fe-Au@Alg and Fe-Au@Alg with cisplatin mixed with laser irradiation exhibited a significant reduction in cell viability after 5 min.  
Conclusion: Hydrogel co-loaded with cisplatin and Iron oxide–gold core–shell nanoparticles are stable construct to combine chemo-photothermal therapy. Therefore, they can be used as a computed tomography-traceable nanocarrie, enabling us to monitor the delivery of therapeutics.
کلیدواژه‌ها
Chemo-Photothermal Therapy؛ Iron Oxide–Gold Core–Shell Nanoparticles؛ Cisplatin؛ Nanoparticles؛ KB Cells
سایر فایل های مرتبط با مقاله
مراجع
  1. Seeta Rama Raju G, Benton L, Pavitra E, Yu JS. Multifunctional nanoparticles: recent progress in cancer therapeutics. Chem Commun (Camb). 2015;51(68):13248-59. doi: 10.1039/c5cc04643b. PubMed PMID: 26234539.
  2. Dreaden EC, Alkilany AM, Huang X, Murphy CJ, El-Sayed MA. The golden age: gold nanoparticles for biomedicine. Chem Soc Rev. 2012;41(7):2740-79. doi: 10.1039/c1cs15237h. PubMed PMID: 22109657. PubMed PMCID: PMC5876014.
  3. Moon JH, Moxley Jr JW, Zhang P, Cui H. Nanoparticle approaches to combating drug resistance. Future Med Chem. 2015;7(12):1503-10. doi: 10.4155/fmc.15.82. PubMed PMID: 26334205.
  4. Konings AWT. Thermoradiotherapy and Thermochemotherapy. Chapter, Interaction of heat and drugs in vitro and in vivo. Berlin, Heidelberg: Springer; 1995. p. 89-102.
  5. Ghaznavi H, Hosseini-Nami S, Kamrava SK, Irajirad R, et al. Folic acid conjugated PEG coated gold-iron oxide core-shell nanocomplex as a potential agent for targeted photothermal therapy of cancer. Artif Cells Nanomed Biotechnol. 2018;46(8):1594-604. doi: 10.1080/21691401.2017.1384384. PubMed PMID: 28994325.
  6. Beik J, Abed Z, Shakeri-Zadeh A, Nourbakhsh M, Shiran MB. Evaluation of the sonosensitizing properties of nano-graphene oxide in comparison with iron oxide and gold nanoparticles. Physica E: Low Dimens Syst Nanostruct. 2016;81:308-14. doi: 10.1016/j.physe.2016.03.023.
  7. Beik J, Abed Z, Ghadimi-Daresajini A, Nourbakhsh M, et al. Measurements of nanoparticle-enhanced heating from 1MHz ultrasound in solution and in mice bearing CT26 colon tumors. J Therm Biol. 2016;62(Pt A):84-9. doi: 10.1016/j.jtherbio.2016.10.007. PubMed PMID: 27839555.
  8. Taghizadeh B, Taranejoo S, Monemian SA, Salehi Moghaddam Z, et al. Classification of stimuli-responsive polymers as anticancer drug delivery systems. Drug Deliv. 2015;22(2):145-55. doi: 10.3109/10717544.2014.887157. PubMed PMID: 24547737.
  9. Yang X, Yang M, Pang B, Vara M, Xia Y. Gold Nanomaterials at Work in Biomedicine. Chem Rev. 2015;115(19):10410-88. doi: 10.1021/acs.chemrev.5b00193. PubMed PMID: 26293344.
  10. Neshastehriz A, Tabei M, Maleki S, Eynali S, Shakeri-Zadeh A. Photothermal therapy using folate conjugated gold nanoparticles enhances the effects of 6MV X-ray on mouth epidermal carcinoma cells. J Photochem Photobiol B. 2017;172:52-60. doi: 10.1016/j.jphotobiol.2017.05.012. PubMed PMID: 28527427.
  11. Amini SM. Gold nanostructures absorption capacities of various energy forms for thermal therapy applications. J Therm Biol. 2019;79:81-4. doi: 10.1016/j.jtherbio.2018.12.007. PubMed PMID: 30612690.
  12. Beik J, Khademi S, Attaran N, Sarkar S, et al. A Nanotechnology-based Strategy to Increase the Efficiency of Cancer Diagnosis and Therapy: Folate-conjugated Gold Nanoparticles. Curr Med Chem. 2017;24(39):4399-416. doi: 10.2174/0929867324666170810154917. PubMed PMID: 28799495.
  13. Shakeri-Zadeh A, Eshghi H, Mansoori GA, Hashemian AR. Gold nanoparticles conjugated with folic acid using mercaptohexanol as the linker. J Nanotech Progress Int. 2009;1(1):1-44.
  14. Alamzadeh Z, Beik J, Pirhajati Mahabadi V, Abbasian Ardekani A, et al. Ultrastructural and optical characteristics of cancer cells treated by a nanotechnology based chemo-photothermal therapy method. J Photochem Photobiol B. 2019;192:19-25. doi: 10.1016/j.jphotobiol.2019.01.005. PubMed PMID: 30665146.
  15. Qin Z, Bischof JC. Thermophysical and biological responses of gold nanoparticle laser heating. Chem Soc Rev. 2012;41(3):1191-217. doi: 10.1039/c1cs15184c. PubMed PMID: 21947414.
  16. Eyvazzadeh N, Shakeri-Zadeh A, Fekrazad R, Amini E, et al. Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer. Lasers Med Sci. 2017;32(7):1469-77. doi: 10.1007/s10103-017-2267-x. PubMed PMID: 28674789.
  17. Fakhimikabir H, Tavakoli MB, Zarrabi A, Amouheidari A, Rahgozar S. Could FA-PG-SPIONs act as a hyperthermia sensitizing agent? An in vitro study. J Therm Biol. 2018;78:73-83. doi: 10.1016/j.jtherbio.2018.09.010. PubMed PMID: 30509670.
  18. Mirrahimi M, Hosseini V, Kamrava SK, Attaran N, et al. Selective heat generation in cancer cells using a combination of 808 nm laser irradiation and the folate-conjugated Fe2O3@Au nanocomplex. Artif Cells Nanomed Biotechnol. 2018;46(suppl1):241-53. doi: 10.1080/21691401.2017.1420072. PubMed PMID: 29291635.
  19. Chavanpatil MD, Khdair A, Panyam J. Surfactant-polymer nanoparticles: a novel platform for sustained and enhanced cellular delivery of water-soluble molecules. Pharm Res. 2007;24(4):803-10. doi: 10.1007/s11095-006-9203-2. PubMed PMID: 17318416.
  20. Feng W, Nie W, He C, Zhou X, et al. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers. ACS Appl Mater Interfaces. 2014;6(11):8447-60. doi: 10.1021/am501337s. PubMed PMID: 24745551.
  21. Almalik A, Alradwan I, Kalam MA, Alshamsan A. Effect of cryoprotection on particle size stability and preservation of chitosan nanoparticles with and without hyaluronate or alginate coating. Saudi Pharm J. 2017;25(6):861-7. doi: 10.1016/j.jsps.2016.12.008. PubMed PMID: 28951671. PubMed PMCID: PMC5605945.
  22. Wang L, Li D, Hao Y, Niu M, Hu Y, et al. Gold nanorod-based poly(lactic-co-glycolic acid) with manganese dioxide core-shell structured multifunctional nanoplatform for cancer theranostic applications. Int J Nanomedicine. 2017;12:3059-75. doi: 10.2147/IJN.S128844. PubMed PMID: 28450782. PubMed PMCID: PMC5399988.
  23. Abed Z, Beik J, Laurent S, Eslahi N, Khani T, et al. Iron oxide-gold core-shell nano-theranostic for magnetically targeted photothermal therapy under magnetic resonance imaging guidance. J Cancer Res Clin Oncol. 2019;145(5):1213-9. doi: 10.1007/s00432-019-02870-x. PubMed PMID: 30847551.
  24. Efremova MV, Naumenko VA, Spasova M, Garanina AS, et al. Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics. Sci Rep. 2018;8(1):11295. doi: 10.1038/s41598-018-29618-w. PubMed PMID: 30050080. PubMed PMCID: PMC6062557.
آمار
تعداد مشاهده مقاله: 19,727
تعداد دریافت فایل اصل مقاله: 409


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب