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Dehdari Vais, Rezvan, Yadegari, Hossein, Heli, Hossein, Sattarahmady, Naghmeh. (1400). A β-Amyloid(1-42) Biosensor Based on Molecularly Imprinted Poly-Pyrrole for Early Diagnosis of Alzheimer’s Disease. سامانه مدیریت نشریات علمی, 11(2), 215-228. doi: 10.31661/jbpe.v0i0.1070
Rezvan Dehdari Vais; Hossein Yadegari; Hossein Heli; Naghmeh Sattarahmady. "A β-Amyloid(1-42) Biosensor Based on Molecularly Imprinted Poly-Pyrrole for Early Diagnosis of Alzheimer’s Disease". سامانه مدیریت نشریات علمی, 11, 2, 1400, 215-228. doi: 10.31661/jbpe.v0i0.1070
Dehdari Vais, Rezvan, Yadegari, Hossein, Heli, Hossein, Sattarahmady, Naghmeh. (1400). 'A β-Amyloid(1-42) Biosensor Based on Molecularly Imprinted Poly-Pyrrole for Early Diagnosis of Alzheimer’s Disease', سامانه مدیریت نشریات علمی, 11(2), pp. 215-228. doi: 10.31661/jbpe.v0i0.1070
Dehdari Vais, Rezvan, Yadegari, Hossein, Heli, Hossein, Sattarahmady, Naghmeh. A β-Amyloid(1-42) Biosensor Based on Molecularly Imprinted Poly-Pyrrole for Early Diagnosis of Alzheimer’s Disease. سامانه مدیریت نشریات علمی, 1400; 11(2): 215-228. doi: 10.31661/jbpe.v0i0.1070

A β-Amyloid(1-42) Biosensor Based on Molecularly Imprinted Poly-Pyrrole for Early Diagnosis of Alzheimer’s Disease

Journal of Biomedical Physics and Engineering
مقاله 11، دوره 11، شماره 2، تیر 2021، صفحه 215-228    اصل مقاله (1.67 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1070
نویسندگان
Rezvan Dehdari Vais1؛ Hossein Yadegari2؛ Hossein Heli* 3؛ Naghmeh Sattarahmady3، 4
1PhD Candidate, Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2PhD, Department of Mechanical and Materials Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada
3PhD, Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4PhD, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Alzheimer’s disease (AD) is a common form of dementia, characterized by production and deposition of β-amyloid peptide in the brain. Thus, β-amyloid peptide is a potentially promising biomarker used to diagnose and monitor the progression of AD.
Objective: The study aims to develop a biosensor based on a molecularly imprinted poly-pyrrole for detection of β-amyloid.
Material and Methods: In this experimental study, an imprinted poly-pyrrole was employed as an artificial receptor synthesized by electro-polymerization of pyrrole on screen-printed carbon electrodes in the presence of β-amyloid. β-amyloid acts as a molecular template within the polymer. The biosensor was evaluated by cyclic voltammetry using ferro/ferricyanide marker. The parameters influencing the biosensor performance, including electro-polymerization cycle umbers and β-amyloid binding time were optimized to achieve the best biosensor sensitivity.
Results: The β-amyloid binding affinity with the biosensor surface was evaluated by the Freundlich isotherm, and Freundlich constant and exponent were obtained as 0.22 ng mL-1 and 10.60, respectively. The biosensor demonstrated a detection limit of 1.2 pg mL-1. The biosensor was applied for β-amyloid determination in artificial cerebrospinal fluid.
Conclusion: The biosensor is applicable for early Alzheimer’s disease detection.
کلیدواژه‌ها
Beta-Amyloid؛ β-Amyloid (1-40)؛ Molecular Imprinting؛ Artificial Antibody؛ Neurodegenerative Disease؛ Sensory Aids؛ Biosensing Technique؛ Bioprobe
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