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Nami, Mohammad, Kateb, Babak, Kamali, Ali-Mohammad, Kazemiha, Milad, Rao, KS, Chakrabarti, Tulika, Chakrabarti, Prasun. (1401). The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis. سامانه مدیریت نشریات علمی, 7(1), -. doi: 10.30476/jamsat.2021.90464.1019
Mohammad Nami; Babak Kateb; Ali-Mohammad Kamali; Milad Kazemiha; KS Rao; Tulika Chakrabarti; Prasun Chakrabarti. "The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis". سامانه مدیریت نشریات علمی, 7, 1, 1401, -. doi: 10.30476/jamsat.2021.90464.1019
Nami, Mohammad, Kateb, Babak, Kamali, Ali-Mohammad, Kazemiha, Milad, Rao, KS, Chakrabarti, Tulika, Chakrabarti, Prasun. (1401). 'The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis', سامانه مدیریت نشریات علمی, 7(1), pp. -. doi: 10.30476/jamsat.2021.90464.1019
Nami, Mohammad, Kateb, Babak, Kamali, Ali-Mohammad, Kazemiha, Milad, Rao, KS, Chakrabarti, Tulika, Chakrabarti, Prasun. The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis. سامانه مدیریت نشریات علمی, 1401; 7(1): -. doi: 10.30476/jamsat.2021.90464.1019

The role of endocannabinoid system in sleep deprivation-induced psychosis-like symptoms through hampering prepulse inhibition; a hypothesis

Journal of Advanced Medical Sciences and Applied Technologies
دوره 7، شماره 1، آذر 2022    اصل مقاله (297.86 K)
نوع مقاله: Hypothesis
شناسه دیجیتال (DOI): 10.30476/jamsat.2021.90464.1019
نویسندگان
Mohammad Nami* 1؛ Babak Kateb2؛ Ali-Mohammad Kamali3؛ Milad Kazemiha3؛ KS Rao4؛ Tulika Chakrabarti5؛ Prasun Chakrabarti6
1Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz
2Society for Brain Mapping and Therapeutics, LA, United States
3Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences
4INDICASAT-AIP, 219 Clayton, City of Knowledge 084301103, Panama City, Republic of Panama
5Department of Basic Science (Chemistry), Sir Padampat Singhania University, Udaipur, 3136022, Rajasthan, India
6Provost, Techno India NJR Institute of Technology, Udaipur-313003, Rajasthan, India
چکیده
The interaction between endocannabinoid (eCB) system with in key brain structures such as hippocampus, amygdala and prefrontal cortex and sleep deprivation (SD)-induced psychosis has been less studied. The present hypothesis revolves around the question whether altered chemical dynamics within the eCB system with the resultant impact on cannabinoid receptors in key cortical hubs would impact SD-induced psychosis-like symptoms. Having this investigated research is expected to pave the path towards identifying newer drug targets namely for schizophrenia. Research may be pursued by blocking the eCB system systemically after SD using eCB receptors antagonists to identify if SD still hampers the PPI. Continued research would also need to investigate if antipsychotic and cognitive enhancing drugs, such as cannabidiol and modafinil reverse the effects of SD upon PPI impairments.
کلیدواژه‌ها
Endocanabinoid system؛ Sleep deprivation؛ Animal models؛ Psychosis-like symptoms؛ Drug development
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