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Fatima, Nishat, Kaushik, Vichitra, Ayoub, Amjad. (1400). A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19–Recovered Patients as a Probable Therapy for COVID-19. سامانه مدیریت نشریات علمی, 46(3), 151-168. doi: 10.30476/ijms.2020.86417.1624
Nishat Fatima; Vichitra Kaushik; Amjad Ayoub. "A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19–Recovered Patients as a Probable Therapy for COVID-19". سامانه مدیریت نشریات علمی, 46, 3, 1400, 151-168. doi: 10.30476/ijms.2020.86417.1624
Fatima, Nishat, Kaushik, Vichitra, Ayoub, Amjad. (1400). 'A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19–Recovered Patients as a Probable Therapy for COVID-19', سامانه مدیریت نشریات علمی, 46(3), pp. 151-168. doi: 10.30476/ijms.2020.86417.1624
Fatima, Nishat, Kaushik, Vichitra, Ayoub, Amjad. A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19–Recovered Patients as a Probable Therapy for COVID-19. سامانه مدیریت نشریات علمی, 1400; 46(3): 151-168. doi: 10.30476/ijms.2020.86417.1624

A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19–Recovered Patients as a Probable Therapy for COVID-19

Iranian Journal of Medical Sciences
مقاله 2، دوره 46، شماره 3، مرداد 2021، صفحه 151-168    اصل مقاله (307.93 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2020.86417.1624
نویسندگان
Nishat Fatima؛ Vichitra Kaushik؛ Amjad Ayoub*
School of Pharmacy, Al-Hawash Private University, Homs, Syria
چکیده
Coronavirus disease 2019 (COVID-19) emerged as a new contagion during December 2019, since which time it has triggered a rampant spike in fatality rates worldwide due to insufficient medical treatments and a lack of counteragents and prompted the World Health Organization to declare COVID-19 a public health emergency. It is, therefore, vital to accelerate the screening of new molecules or vaccines to win the battle against this pandemic. Experiences from previous epidemiological data on coronaviruses guide investigators in designing and exploring new compounds for a safe and cost-effective treatment. Several reports on the severe acute respiratory syndrome (SARS) epidemic indicate that severe acute respiratory syndrome coronavirus (SARS-CoV) and the novel COVID-19 use angiotensin-converting enzyme 2 (ACE2) as a receptor for binding to the host cell in the lung epithelia through the spike protein on their virion surface. ACE2 is a mono-carboxypeptidase best known for cleaving major peptides and substrates. Its degree in human airway epithelia positively correlates with coronavirus infection. The treatment approach can be the neutralization of the virus entering lung epithelial cells by using sera containing antibodies collected from COVID-19–recovered patients. Hence, we herein propose a pulmonary aerosolized formulation or a nasal drop using sera, which contain antibodies to prevent, treat, or immunize against COVID-19 infection.
کلیدواژه‌ها
COVID-19؛ Angiotensin-converting enzyme 2؛ Serum؛ Neutralizing؛ Antibodies
سایر فایل های مرتبط با مقاله
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