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Nadimi Parashkouhi, Sadra, Mosaddeghi, Pouria, Bagheri, Ashkan, Moezzi, Seyed Mohammad Iman, Fazel Hoseini, Seyed Mostafa, Farahmandnejad, Mitra, Maleki, Amin, Negahdaripour, Manica. (1399). The dual sides of interferon induction in COVID-19 treatment. سامانه مدیریت نشریات علمی, 7(1), 9-14. doi: 10.30476/tips.2021.89524.1075
Sadra Nadimi Parashkouhi; Pouria Mosaddeghi; Ashkan Bagheri; Seyed Mohammad Iman Moezzi; Seyed Mostafa Fazel Hoseini; Mitra Farahmandnejad; Amin Maleki; Manica Negahdaripour. "The dual sides of interferon induction in COVID-19 treatment". سامانه مدیریت نشریات علمی, 7, 1, 1399, 9-14. doi: 10.30476/tips.2021.89524.1075
Nadimi Parashkouhi, Sadra, Mosaddeghi, Pouria, Bagheri, Ashkan, Moezzi, Seyed Mohammad Iman, Fazel Hoseini, Seyed Mostafa, Farahmandnejad, Mitra, Maleki, Amin, Negahdaripour, Manica. (1399). 'The dual sides of interferon induction in COVID-19 treatment', سامانه مدیریت نشریات علمی, 7(1), pp. 9-14. doi: 10.30476/tips.2021.89524.1075
Nadimi Parashkouhi, Sadra, Mosaddeghi, Pouria, Bagheri, Ashkan, Moezzi, Seyed Mohammad Iman, Fazel Hoseini, Seyed Mostafa, Farahmandnejad, Mitra, Maleki, Amin, Negahdaripour, Manica. The dual sides of interferon induction in COVID-19 treatment. سامانه مدیریت نشریات علمی, 1399; 7(1): 9-14. doi: 10.30476/tips.2021.89524.1075

The dual sides of interferon induction in COVID-19 treatment

Trends in Pharmaceutical Sciences
مقاله 2، دوره 7، شماره 1، خرداد 2021، صفحه 9-14    اصل مقاله (484.21 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/tips.2021.89524.1075
نویسندگان
Sadra Nadimi Parashkouhi1، 2، 3، 4؛ Pouria Mosaddeghi1، 2، 3، 4؛ Ashkan Bagheri1، 2، 3، 4؛ Seyed Mohammad Iman Moezzi1، 2، 3، 4؛ Seyed Mostafa Fazel Hoseini1، 2، 3، 4؛ Mitra Farahmandnejad1، 2، 3، 4؛ Amin Maleki1؛ Manica Negahdaripour* 1، 2
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
4Cellular and Molecular Medicine Student Research Group, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a pandemic with immense impacts on different aspects of human life globally. Generally, type I and II interferons are essential cytokines to combat viral infections including COVID-19. However, SARS-CoV-2 adopts evasion mechanisms to overcome interferon-mediated antiviral responses and neutralizes a key human defensive strategy. The aim of this mini-review is to survey both beneficial and non-beneficial effects of interferon during COVID-19 disease course. The indication of interferon-α2b or interferon β-1a has shown benefit at the early stages of COVID-19 in some clinical trials; though, interferon administration could only help in the incubation period or before the peak viral load. The incubation period and the duration from the symptom onset till the peak viral load has been estimated 5-6 and 2-3 days, respectively. On the other hand, an increase of interferon level in the disease’s late stages leads to delayed recovery and probably increased mortality rates due to the upregulation of ACE-2 expression in human airway epithelial cells, leading to the facilitation of virus entry into the host cells. Besides, it promotes the overactivation of inflammatory responses, which often happens in the disease’s pulmonary phase causing the cytokine storm. In this stage, antiviral agents might not work, and anti-inflammatory drugs, including corticosteroids (dexamethasone or prednisolone), tocilizumab (an IL-6 inhibitor), or anakinra (a recombinant IL-1 receptor antagonist), are beneficial. Some other proposed drugs such as TNF-α inhibitors and JAK inhibitors need further investigations in future studies.
کلیدواژه‌ها
Anti-inflammatory؛ Antiviral؛ Coronavirus؛ Cytokine storm؛ Pandemic؛ SARS-CoV-2
مراجع

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