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Mottaghi, Shaghayegh, Sagheb, Mohammad Mahdi, Azarpira, Negar, Abdizadeh, Faezeh, Faeghi, Romina, Karimzadeh, Iman. (1400). Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients. سامانه مدیریت نشریات علمی, 46(6), 444-453. doi: 10.30476/ijms.2020.85872.1550
Shaghayegh Mottaghi; Mohammad Mahdi Sagheb; Negar Azarpira; Faezeh Abdizadeh; Romina Faeghi; Iman Karimzadeh. "Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients". سامانه مدیریت نشریات علمی, 46, 6, 1400, 444-453. doi: 10.30476/ijms.2020.85872.1550
Mottaghi, Shaghayegh, Sagheb, Mohammad Mahdi, Azarpira, Negar, Abdizadeh, Faezeh, Faeghi, Romina, Karimzadeh, Iman. (1400). 'Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients', سامانه مدیریت نشریات علمی, 46(6), pp. 444-453. doi: 10.30476/ijms.2020.85872.1550
Mottaghi, Shaghayegh, Sagheb, Mohammad Mahdi, Azarpira, Negar, Abdizadeh, Faezeh, Faeghi, Romina, Karimzadeh, Iman. Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients. سامانه مدیریت نشریات علمی, 1400; 46(6): 444-453. doi: 10.30476/ijms.2020.85872.1550

Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients

Iranian Journal of Medical Sciences
مقاله 5، دوره 46، شماره 6، بهمن 2021، صفحه 444-453    اصل مقاله (268.25 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.85872.1550
نویسندگان
Shaghayegh Mottaghi1؛ Mohammad Mahdi Sagheb2؛ Negar Azarpira3؛ Faezeh Abdizadeh1؛ Romina Faeghi1؛ Iman Karimzadeh* 1
1Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Nephrology-Urology Research Center and Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Glucocorticoids are pivotal components of immunosuppressive regimens in solid organ transplantations. This study aimed to assess the possible association between the ER22/23EK, N363S, and Bcl1 polymorphisms, and short-term clinical outcomes, including acute rejection and delayed graft function (DGF), in kidney transplantation recipients.
Methods: A case-control study was conducted in a two-year period on adults with transplanted kidneys, comprised of subjects without rejection (n=50, control) and those with documented rejection within one year after transplantation (n=50, case), between April 2017 and September 2018, in Shiraz, Iran. Demographic characteristics and clinical and paraclinical findings were gathered. The genotyping of the ER22/23EK, N363S, and Bcl1 polymorphisms was carried out via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The association between the genotypes and DGF as well as rejection types was evaluated using either the Chi square test or Fisher exact test. A stepwise logistic regression analysis was conducted to determine the independent factors of acute rejection within the first year after transplantation.
Results: The study population consisted of 64 men and 36 women. The frequency of mutated alleles was 0.32 for G (Bcl1), 0.02 for S (N363S), and 0.065 for A (ER22/23EK). There was no significant association either between the studied polymorphisms and acute rejection or between the Bcl1 (P=0.17), N363S (P=0.99), and ER22/23EK (P=0.99) genotypes and DGF. The length of hospital stay after kidney transplantation was slightly more in N363N and ER22/23EK wild allele carriers. However, this difference was not statistically significant.
Conclusion: Our data suggested no statistically significant association between the genotypes of the studied polymorphisms and early clinical outcomes after kidney transplantation.
کلیدواژه‌ها
Kidney transplantation؛ Receptors؛ Glucocorticoids؛ Polymorphism؛ Genetic
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