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Sachan, Anjali, Gupta, Seema, Singh, Navin. (1400). Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation. سامانه مدیریت نشریات علمی, 12(1), 83-90. doi: 10.31661/jbpe.v0i0.2007-1132
Anjali Sachan; Seema Gupta; Navin Singh. "Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation". سامانه مدیریت نشریات علمی, 12, 1, 1400, 83-90. doi: 10.31661/jbpe.v0i0.2007-1132
Sachan, Anjali, Gupta, Seema, Singh, Navin. (1400). 'Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation', سامانه مدیریت نشریات علمی, 12(1), pp. 83-90. doi: 10.31661/jbpe.v0i0.2007-1132
Sachan, Anjali, Gupta, Seema, Singh, Navin. Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation. سامانه مدیریت نشریات علمی, 1400; 12(1): 83-90. doi: 10.31661/jbpe.v0i0.2007-1132

Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation

Journal of Biomedical Physics and Engineering
مقاله 9، دوره 12، شماره 1، اردیبهشت 2022، صفحه 83-90    اصل مقاله (504.7 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2007-1132
نویسندگان
Anjali Sachan1؛ Seema Gupta* 1؛ Navin Singh2
1MD, Department of Radiotherapy, King George’s Medical University, Lucknow, Uttar Pradesh, India
2PhD, Department of Radiotherapy, King George’s Medical University, Lucknow, Uttar Pradesh, India
چکیده
Background: Multimodality treatment is required for the management of head and neck cancer. Functional impairment and toxicities associated with surgery and radiation accentuate the need to develop innovative therapeutic strategies in the management of these patients to improve survival and reduce toxicity. In this study, we have compared treatment effects in patients of advanced head and neck squamous cell cancer treated by open field and 3DCRT treatment planning techniques.
Objective: This study aims to evaluate open field and 3DCRT treatment planning techniques in advanced head and neck squamous cell cancer patients managed by chemoradiation in the scenario of limited resources.
Material and Methods: In this analytical study, 40 histologically proven unresectable advanced squamous cell carcinoma patients of oropharynx and larynx were allocated in two groups to receive 70 Gy in 35 fractions in 7 weeks with concurrent cisplatinum35 mg/m2 weekly either with open-field technique or three dimensional conformal radiotherapy (3DCRT) by ElektaSynergy linear accelerator. Target volume coverage and dose received by organ at risk (OARs) were compared. Clinical outcome in terms of response and toxicities is also evaluated in this study.
Results: Plans with best possible coverage of the target volume were obtained. No significant difference was found in the dose received by the spinal cord; however, it was possible to prevent higher dose to brain stem with 3DCRTin node negative patients of oropharynx cancer and larynx cancer. Skin toxicities were significantly lower in 3DCRT arm.
Conclusion: In low resource settings with increased burden of locally advanced disease, both open-field and 3DCRT treatment techniques are comparable in terms of target coverage, OARs preservation, toxicity and treatment response.
کلیدواژه‌ها
Head and Neck Cancer؛ Radiotherapy, Conformal؛ Radiation Dosage؛ Radiation Effects؛ Dose Response
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مراجع
  1. Braakhuis BJ, Brakenhoff RH, René Leemans C. Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors. Ann Oncol. 2012;23(suppl 10):x173-7. doi: 10.1093/annonc/mds299. PubMed PMID: 22987957.
  2. Purdy JA. 3-D conformal radiotherapy: a new era in the irradiation of cancer. 29th Annual San Francisco Cancer Symposium; San Francisco, Calif: Basel, Karger; 1996. p. 1–16.
  3. Purdy JA. From new frontiers to new standards of practice: advances in radiotherapyplanning and delivery. Front Radiat Ther Oncol. 2007;40:18-39. doi: 10.1159/000106026.
  4. Purdy JA. Advances in the planning and delivery of radiotherapy: new expectations,new standards of care. Front Radiat Ther Oncol. 2011;43:1-28. doi: 10.1159/000322396.
  5. Thiagarajan A, Caria N, Schöder H, Iyer NG, Wolden S, Wong RJ, et al. Target volume delineation in oropharyngeal cancer: impact of PET, MRI, and physical examination. Int J Radiat Oncol Biol Phys. 2012;83(1):220-7. doi: 10.1016/j.ijrobp.2011.05.060. PubMed PMID: 22035663.
  6. Gupta T, Kanna S, Laskar SG, Agarwal J P. Systematic review and meta-analyses of intensity-modulated radiation therapy versus conventional two-dimensional and/or or three-dimensional radiotherapy in curative-intent management of head and neck squamous cell carcinoma. PLoS One. 2018;13(7):e0200137. doi: 10.1371/journal.pone.0200137. PubMed PMID: 29979726. PubMed PMCID: PMC6034843.
  7. Morgan HE, Sher DJ. Adaptive radiotherapy for head and neck cancer. Cancers Head Neck. 2020;5:1. doi: 10.1186/s41199-019-0046-z. eCollection 2020. PubMed PMID: 31938572. PubMed PMCID: PMC6953291.
  8. Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, et al. Final results of the 94-01 French Head andNeck Oncology and Radiotherapy Group randomized trial comparing radiotherapyalone with concomitant radiochemotherapy in advanced-stage oropharynxcarcinoma. J Clin Oncol. 2004;22(1):69-76. doi: 10.1200/JCO.2004.08.021. PubMed PMID: 14657228.
  9. Wendt TG, Grabenbauer GG, Rödel CM, Thiel HJ, Aydin H, Rohloff R, et al. Simultaneous radiochemotherapyversus radiotherapy alone in advanced head and neck cancer: a randomizedmulticenter study. J Clin Oncol. 1998;16(4):1318-24. doi: 10.1200/JCO.1998.16.4.1318. PubMed PMID: 9552032.
  10. Hölscher T, Bentzen SM, Baumann M. Influence of connective tissue diseases on the expression of radiation side effects: A systematic review. Radiother Oncol. 2006;78(2):123-30. doi: 10.1016/j.radonc.2005.12.013.
  11. Wijers OB, Levendag PC, Braaksma MMJ, Boonzaaijer M, Visch LL, Schmitz PIM. Patients with head and neck cancer cured by radiation therapy: A survey of the dry mouth syndrome in long-term survivors. Head Neck. 2002;24(8):737-47. doi: 10.1002/hed.10129. PubMed PMID: 12203798.
  12. Nutting, CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011;12(2):127-36. doi: 10.1016/S1470-2045(10)70290-4. PubMed PMID: 21236730. PubMed PMCID: PMC3033533.
  13. Deasy JO, Moiseenko V, Marks L, Chao KSC, Nam J, Eisbruchet A. Radiotherapy Dose-Volume Effects on Salivary Gland Function. Int J Radiat Oncol Biol Phys. 2010;76(3):S58-63. doi: 10.1016/j.ijrobp.2009.06.090. PubMed PMID: 20171519. PubMed PMCID: PMC4041494.
  14. Joseph B, Kumar RV, Champaka G, Shenoy A, Sabitha KS, Lokesh V, et al. Biological tailoring of adjuvant radiotherapy in head and neck and oral malignancies – The potential role of p53 and eIF4E as predictive parameters. Indian J Cancer. 2019;56(4):330-4. doi: 10.4103/ijc.IJC_56_18. PubMed PMID: 31607702.
  15. Herrassi MY, Bentayeb F, Malisan MR. Comparative study of four advanced 3d-conformal radiation therapy treatment planning techniques for head and neck cancer. J Med Phys. 2013;38(2):98-105. doi: 10.4103/0971-6203.111331. PubMed PMID: 23776314. PubMed PMCID: PMC3683308.
  16. Lee N, Akazawa C, Akazawa P, Quivey JM, Tang C, Verhey LJ, et al. A forward-planned treatment technique using multisegments in the treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004;59(2):584-94. doi: 10.1016/j.ijrobp.2004.02.005. PubMed PMID: 15145180.
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