LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,519
تعداد مشاهده مقاله45,424,441
تعداد دریافت فایل اصل مقاله11,296,677
Shafiee, Mina, Abolmaali, Samirasadat, Abedanzadeh, Mozhgan, Abedi, Mehdi, Tamaddon, Alimohammad. (1400). Synthesis of Pore-Size-Tunable Mesoporous Silica Nanoparticles by Simultaneous Sol-Gel and Radical Polymerization to Enhance Silibinin Dissolution. سامانه مدیریت نشریات علمی, 46(6), 475-486. doi: 10.30476/ijms.2020.86173.1595
Mina Shafiee; Samirasadat Abolmaali; Mozhgan Abedanzadeh; Mehdi Abedi; Alimohammad Tamaddon. "Synthesis of Pore-Size-Tunable Mesoporous Silica Nanoparticles by Simultaneous Sol-Gel and Radical Polymerization to Enhance Silibinin Dissolution". سامانه مدیریت نشریات علمی, 46, 6, 1400, 475-486. doi: 10.30476/ijms.2020.86173.1595
Shafiee, Mina, Abolmaali, Samirasadat, Abedanzadeh, Mozhgan, Abedi, Mehdi, Tamaddon, Alimohammad. (1400). 'Synthesis of Pore-Size-Tunable Mesoporous Silica Nanoparticles by Simultaneous Sol-Gel and Radical Polymerization to Enhance Silibinin Dissolution', سامانه مدیریت نشریات علمی, 46(6), pp. 475-486. doi: 10.30476/ijms.2020.86173.1595
Shafiee, Mina, Abolmaali, Samirasadat, Abedanzadeh, Mozhgan, Abedi, Mehdi, Tamaddon, Alimohammad. Synthesis of Pore-Size-Tunable Mesoporous Silica Nanoparticles by Simultaneous Sol-Gel and Radical Polymerization to Enhance Silibinin Dissolution. سامانه مدیریت نشریات علمی, 1400; 46(6): 475-486. doi: 10.30476/ijms.2020.86173.1595

Synthesis of Pore-Size-Tunable Mesoporous Silica Nanoparticles by Simultaneous Sol-Gel and Radical Polymerization to Enhance Silibinin Dissolution

Iranian Journal of Medical Sciences
مقاله 8، دوره 46، شماره 6، بهمن 2021، صفحه 475-486    اصل مقاله (1.88 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.86173.1595
نویسندگان
Mina Shafiee1؛ Samirasadat Abolmaali* 2؛ Mozhgan Abedanzadeh2؛ Mehdi Abedi2؛ Alimohammad Tamaddon2
1Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Silibinin (SBN), a major active constituent of milk thistle seeds, exhibits numerous pharmacological activities. However, its oral bioavailability is low due to poor water solubility. This study aimed to develop a new synthetic approach for tuning the pore characteristics of mesoporous silica nanoparticles (MSNs) intended for the oral delivery of SBN. In addition, the effects of the pore diameter of MSNs on the loading capacity and the release profile of SBN were investigated.
Methods: The present study was performed at Shiraz University of Medical Sciences, Shiraz, Iran, in 2019. This synthesis method shares the features of the simultaneous free-radical polymerization of methyl methacrylate and the sol-gel reaction of the silica precursor at the n-heptane/water interface. SBN was loaded onto MSNs, the in vitro release was determined, and the radical scavenging activities were compared between various pH values using the analysis of variance.
Results: According to the Brunauer–Emmett–Teller protocol, the pore sizes were well-tuned in the range of 2 to 7 nm with a large specific surface area (600–1200 m2/g). Dynamic light scattering results showed that different volume ratios of n-heptane/water resulted in different sizes, ranging from 25 to 100 nm. Interestingly, high SBN loading (13% w/w) and the sustained release of the total drug over 12 hours were achieved in the phosphate buffer (pH=6.8). Moreover, the antioxidant activity of SBN was well preserved in acidic gastric pH.
Conclusion: Well-tuned pores of MSNs provided a proper substrate, and thus, enhanced SBN loading and oral dissolution and preserved its antioxidant activity. Nevertheless, further in vitro and in vivo investigations are needed.
کلیدواژه‌ها
Nanoparticles؛ Silicon dioxide؛ Polymerization؛ Silybin؛ Antioxidants
سایر فایل های مرتبط با مقاله
مراجع
  1. Yan B, Gu Y, Zhao J, Liu Y, Wang L, Wang Y. Self-microemulsion Technology for Water-insoluble Drug Delivery. Current Nanoscience. 2019;15:576-88. doi: 10.2174/1573413715666190112122107.
  2. Haque ST, Chowdhury EH. Recent Progress in Delivery of Therapeutic and Imaging Agents Utilizing Organic-Inorganic Hybrid Nanoparticles. Curr Drug Deliv. 2018;15:485-96. doi: 10.2174/1567201814666171120114034. PubMed PMID: 29165073.
  3. Kao K-C, Mou C-Y. Pore-expanded mesoporous silica nanoparticles with alkanes/ethanol as pore expanding agent. Microporous and mesoporous materials. 2013;169:7-15. doi: 10.1016/j.micromeso.2012.09.030.
  4. Nandiyanto ABD, Kim S-G, Iskandar F, Okuyama K. Synthesis of spherical mesoporous silica nanoparticles with nanometer-size controllable pores and outer diameters. Microporous and Mesoporous Materials. 2009;120:447-53. doi: 10.1016/j.micromeso.2008.12.019.
  5. Vangijzegem T, Stanicki D, Laurent S. Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics. Expert Opin Drug Deliv. 2019;16:69-78. doi: 10.1080/17425247.2019.1554647. PubMed PMID: 30496697.
  6. Lupa D, Oćwieja M, Piergies N, Baliś A, Paluszkiewicz C, Adamczyk Z. Gold nanoparticles deposited on silica microparticles-Electrokinetic characteristics and application in SERS. Colloid and Interface Science Communications. 2019;33:100219. doi: 10.1016/j.colcom.2019.100219.
  7. ALOthman ZA. A review: fundamental aspects of silicate mesoporous materials. Materials. 2012;5:2874-902. doi: 10.3390/ma5122874.
  8. Gun’ko VM, Turov VV, Protsak I, Krupska TV, Pakhlov EM, Zhang D. Interfacial phenomena in composites with nanostructured succinic acid bound to hydrophilic and hydrophobic nanosilicas. Colloid and Interface Science Communications. 2020;35:100251. doi: 10.1016/j.colcom.2020.100251.
  9. Farjadian F, Roointan A, Mohammadi-Samani S, Hosseini M. Mesoporous silica nanoparticles: synthesis, pharmaceutical applications, biodistribution, and biosafety assessment. Chemical Engineering Journal. 2019;359:684-705. doi: 10.1016/j.cej.2018.11.156.
  10. Yang P, Gai S, Lin J. Functionalized mesoporous silica materials for controlled drug delivery. Chem Soc Rev. 2012;41:3679-98. doi: 10.1039/c2cs15308d. PubMed PMID: 22441299.
  11. Shen SC, Ng WK, Chia L, Hu J, Tan RB. Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: effect of pore and particle size. Int J Pharm. 2011;410:188-95. doi: 10.1016/j.ijpharm.2011.03.018. PubMed PMID: 21419202.
  12. Chen JF, Ding HM, Wang JX, Shao L. Preparation and characterization of porous hollow silica nanoparticles for drug delivery application. Biomaterials. 2004;25:723-7. doi: 10.1016/s0142-9612(03)00566-0. PubMed PMID: 14607511.
  13. Kilpelainen M, Riikonen J, Vlasova MA, Huotari A, Lehto VP, Salonen J, et al. In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release. 2009;137:166-70. doi: 10.1016/j.jconrel.2009.03.017. PubMed PMID: 19345247.
  14. von Schonfeld J, Weisbrod B, Muller MK. Silibinin, a plant extract with antioxidant and membrane stabilizing properties, protects exocrine pancreas from cyclosporin A toxicity. Cell Mol Life Sci. 1997;53:917-20. doi: 10.1007/s000180050111. PubMed PMID: 9447243.
  15. Romanucci V, Gravante R, Cimafonte M, Marino CD, Mailhot G, Brigante M, et al. Phosphate-Linked Silibinin Dimers (PLSd): New Promising Modified Metabolites. Molecules. 2017;22. doi: 10.3390/molecules22081323. PubMed PMID: 28800072; PubMed Central PMCID: PMCPMC6152259.
  16. Javed S, Kohli K, Ali M. Reassessing bioavailability of silymarin. Altern Med Rev. 2011;16:239-49. PubMed PMID: 21951025.
  17. Patel A, Heussen P, Hazekamp J, Velikov KP. Stabilisation and controlled release of silibinin from pH responsive shellac colloidal particles. Soft Matter. 2011;7:8549-55. doi: 10.1039/c1sm05853c.
  18. Cao X, Deng W, Fu M, Zhu Y, Liu H, Wang L, et al. Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: in vitro release kinetics and in vitro/in vivo correlations in beagle dogs. Eur J Pharm Sci. 2013;48:64-71. doi: 10.1016/j.ejps.2012.10.012. PubMed PMID: 23123331.
  19. Ahmadi Nasab N, Hassani Kumleh H, Beygzadeh M, Teimourian S, Kazemzad M. Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment. Artif Cells Nanomed Biotechnol. 2018;46:75-81. doi: 10.1080/21691401.2017.1290648. PubMed PMID: 28278578.
  20. Zeynizadeh B, Aminzadeh FM, Mousavi H. Green and convenient protocols for the efficient reduction of nitriles and nitro compounds to corresponding amines with NaBH 4 in water catalyzed by magnetically retrievable CuFe 2 O 4 nanoparticles. Research on Chemical Intermediates. 2019;45:3329-57. doi: 10.1007/s11164-019-03794-4.
  21. Holzwarth U, Gibson N. The Scherrer equation versus the ‘Debye-Scherrer equation’. Nat Nanotechnol. 2011;6:534. doi: 10.1038/nnano.2011.145. PubMed PMID: 21873991.
  22. Cai K, He X, Song Z, Yin Q, Zhang Y, Uckun FM, et al. Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency. J Am Chem Soc. 2015;137:3458-61. doi: 10.1021/ja513034e. PubMed PMID: 25741752.
  23. Ayawei N, Ebelegi AN, Wankasi D. Modelling and interpretation of adsorption isotherms. Journal of Chemistry. 2017;2017. doi: 10.1155/2017/3039817.
  24. Abedi M, Abolmaali SS, Abedanzadeh M, Farjadian F, Mohammadi Samani S, Tamaddon AM. Core-Shell Imidazoline-Functionalized Mesoporous Silica Superparamagnetic Hybrid Nanoparticles as a Potential Theranostic Agent for Controlled Delivery of Platinum(II) Compound. Int J Nanomedicine. 2020;15:2617-31. doi: 10.2147/IJN.S245135. PubMed PMID: 32368044; PubMed Central PMCID: PMCPMC7182466.
  25. Borandeh S, Abdolmaleki A, Abolmaali SS, Tamaddon AM. Synthesis, structural and in-vitro characterization of beta-cyclodextrin grafted L-phenylalanine functionalized graphene oxide nanocomposite: A versatile nanocarrier for pH-sensitive doxorubicin delivery. Carbohydr Polym. 2018;201:151-61. doi: 10.1016/j.carbpol.2018.08.064. PubMed PMID: 30241806.
  26. Rezaei-Sadabady R, Eidi A, Zarghami N, Barzegar A. Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes. Artif Cells Nanomed Biotechnol. 2016;44:128-34. doi: 10.3109/21691401.2014.926456. PubMed PMID: 24959911.
  27. Deng J, Cheng W, Yang G. A novel antioxidant activity index (AAU) for natural products using the DPPH assay. Food Chemistry. 2011;125:1430-5. doi: 10.1016/j.foodchem.2010.10.031.
  28. Rathouský J, Schulz-Ekloff G, Had J, Zukal A. Time-resolved in situ X-ray diffraction study of MCM-41 structure formation from a homogeneous environment. Physical Chemistry Chemical Physics. 1999;1:3053-7. doi: 10.1039/a901968e.
  29. Abedi M, Abolmaali SS, Abedanzadeh M, Borandeh S, Samani SM, Tamaddon AM. Citric acid functionalized silane coupling versus post-grafting strategy for dual pH and saline responsive delivery of cisplatin by Fe3O4/carboxyl functionalized mesoporous SiO2 hybrid nanoparticles: A-synthesis, physicochemical and biological characterization. Mater Sci Eng C Mater Biol Appl. 2019;104:109922. doi: 10.1016/j.msec.2019.109922. PubMed PMID: 31499936.
  30. Chiarakorn S, Areerob T, Grisdanurak N. Influence of functional silanes on hydrophobicity of MCM-41 synthesized from rice husk. Science and Technology of Advanced Materials. 2007;8:110. doi: 10.1016/j.stam.2006.11.011.
  31. Mahmoodi M, Behzad-Behbahani A, Sharifzadeh S, Abolmaali SS, Tamaddon A. Co-condensation synthesis of well-defined mesoporous silica nanoparticles: effect of surface chemical modification on plasmid DNA condensation and transfection. IET Nanobiotechnol. 2017;11:995-1004. doi: 10.1049/iet-nbt.2017.0078. PubMed PMID: 29155400.
  32. Johansson EM, Córdoba JM, Odén M. The effects on pore size and particle morphology of heptane additions to the synthesis of mesoporous silica SBA-15. Microporous and Mesoporous Materials. 2010;133:66-74. doi: 10.1016/j.micromeso.2010.04.016.
  33. Zhang Y, Zhi Z, Jiang T, Zhang J, Wang Z, Wang S. Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan. J Control Release. 2010;145:257-63. doi: 10.1016/j.jconrel.2010.04.029. PubMed PMID: 20450945.
  34. Yang C, Zhang J, Han S, Wang X, Wang L, Yu W, et al. Compositional controls on pore-size distribution by nitrogen adsorption technique in the Lower Permian Shanxi Shales, Ordos Basin. Journal of Natural Gas Science and Engineering. 2016;34:1369-81. doi: 10.1016/j.jngse.2016.08.026.
  35. Donohue M, Aranovich G. Classification of Gibbs adsorption isotherms. Advances in colloid and interface science. 1998;76:137-52. doi: 10.1016/S0001-8686(98)00044-X.
  36. Cao X, Fu M, Wang L, Liu H, Deng W, Qu R, et al. Oral bioavailability of silymarin formulated as a novel 3-day delivery system based on porous silica nanoparticles. Acta Biomater. 2012;8:2104-12. doi: 10.1016/j.actbio.2012.02.011. PubMed PMID: 22343518.
  37. Fazio E, Scala A, Grimato S, Ridolfo A, Grassi G, Neri F. Laser light triggered smart release of silibinin from a PEGylated-PLGA gold nanocomposite. J Mater Chem B. 2015;3:9023-32. doi: 10.1039/c5tb01076d. PubMed PMID: 32263033.
  38. Onken B, Traina S. The sorption of pyrene and anthracene to humic acid-mineral complexes: Effect of fractional organic carbon content. J Environ Qual. 1997;26:126-32.doi: 10.2134/jeq1997.00472425002600010019x.
  39. Bleam W. Soil and Environmental Chemistry. 2nd ed. Amsterdam: Elsevier; 2017.
  40. Atchudan R, Perumal S, Edison TNJI, Lee YR. Highly graphitic carbon nanosheets synthesized over tailored mesoporous molecular sieves using acetylene by chemical vapor deposition method. RSC advances. 2015;5:93364-73. doi: 10.1039/C5RA15288G.
  41. Carriazo D, del Arco M, Fernandez A, Martin C, Rives V. Inclusion and release of fenbufen in mesoporous silica. J Pharm Sci. 2010;99:3372-80. doi: 10.1002/jps.22096. PubMed PMID: 20232455.
  42. Sahibzada MUK, Sadiq A, Khan S, Faidah HS, Naseemullah, Khurram M, et al. Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability. Drug Des Devel Ther. 2017;11:1453-64. doi: 10.2147/DDDT.S133806. PubMed PMID: 28553075; PubMed Central PMCID: PMCPMC5440029.
  43. Lu C, Lu Y, Chen J, Zhang W, Wu W. Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system. Eur J Pharm Biopharm. 2007;66:210-9. doi: 10.1016/j.ejpb.2006.11.008. PubMed PMID: 17196805.
  44. Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67:217-23. PubMed PMID: 20524422.
  45. Singhvi G, Singh M. Review: in-vitro drug release characterization models. Int J Pharm Stud Res. 2011;2:77-84.
آمار
تعداد مشاهده مقاله: 5,316
تعداد دریافت فایل اصل مقاله: 3,822


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب