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Azadi, Roza, Musavi, Seyyedeh Elaheh, Motekef, Negar, Rezayat, Seyed Mehdi, Jafari, Mahmoudreza. (1399). Preparation and Characterization of Berberine loaded Micelle Formulations with Approach to Oral Drug Delivery. سامانه مدیریت نشریات علمی, 6(4), 255-262. doi: 10.30476/tips.2021.88569.1070
Roza Azadi; Seyyedeh Elaheh - Musavi; Negar Motekef; Seyed Mehdi Rezayat; Mahmoudreza Jafari. "Preparation and Characterization of Berberine loaded Micelle Formulations with Approach to Oral Drug Delivery". سامانه مدیریت نشریات علمی, 6, 4, 1399, 255-262. doi: 10.30476/tips.2021.88569.1070
Azadi, Roza, Musavi, Seyyedeh Elaheh, Motekef, Negar, Rezayat, Seyed Mehdi, Jafari, Mahmoudreza. (1399). 'Preparation and Characterization of Berberine loaded Micelle Formulations with Approach to Oral Drug Delivery', سامانه مدیریت نشریات علمی, 6(4), pp. 255-262. doi: 10.30476/tips.2021.88569.1070
Azadi, Roza, Musavi, Seyyedeh Elaheh, Motekef, Negar, Rezayat, Seyed Mehdi, Jafari, Mahmoudreza. Preparation and Characterization of Berberine loaded Micelle Formulations with Approach to Oral Drug Delivery. سامانه مدیریت نشریات علمی, 1399; 6(4): 255-262. doi: 10.30476/tips.2021.88569.1070

Preparation and Characterization of Berberine loaded Micelle Formulations with Approach to Oral Drug Delivery

Trends in Pharmaceutical Sciences
مقاله 4، دوره 6، شماره 4، اسفند 2020، صفحه 255-262    اصل مقاله (595.81 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2021.88569.1070
نویسندگان
Roza Azadi1؛ Seyyedeh Elaheh - Musavi* 2؛ Negar Motekef1؛ Seyed Mehdi Rezayat3؛ Mahmoudreza Jafari4
1Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Department of Pharmaceutical Nanotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Berberine (BBR) is a quaternary ammonium salt that possesses plentiful therapeutics properties. But notwithstanding the positive points, it has two negative points: poor aqueous solubility and permeability. These properties are important for achieving good bioavailability and therapeutic effect. Lately nano formulations developed to overcome these challenges through drug encapsulation. The aim of this study was preparation of nano formulations based on surfactant to achieve the best formulation with good characteristics. In this research, nano micellar formulations were prepared by thin film hydration method using poly sorbate 20 as surfactant and BBR as drug to get the good formulation based on high encapsulation efficiency (EE). Then nano micelles were characterized by particle size and polydispersity index (PDI) by DLS, drug encapsulation by UV-Vis spectrophotometer and drug release behavior in simulated gastro fluid (SGF) and simulated intestinal fluid (SIF). BBR successfully was encapsulated within micelles by thin film hydration method. DLS analysis showed average size of nano micelle samples between 9.247 and 18.46 nm, PDI was about 0.271, with maximum percentage of drug encapsulation of 78%. Also fluctuation of drug release was very low in elementary time points in SGF and SIF, and it was approximately sustained release profile. These results showed to achieve a good formulation and in order to have better drug delivery, physical attributes including the size distribution, PDI, and EE should be controlled. Our findings may be benefactress for different applications in variety research fields of pharmaceutical industry. 
کلیدواژه‌ها
Berberine؛ Nano Formulation؛ Drug Delivery؛ Encapsulation؛ Micelle
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