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Mousavi, Azamsadat, Modarres Gilani, Mitra, Akhavan, Setareh, Sheikh Hasani, Shahrzad, Alipour, Abbas, Gholami, Hamideh. (1400). The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery. سامانه مدیریت نشریات علمی, 46(5), 355-363. doi: 10.30476/ijms.2020.81973.0
Azamsadat Mousavi; Mitra Modarres Gilani; Setareh Akhavan; Shahrzad Sheikh Hasani; Abbas Alipour; Hamideh Gholami. "The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery". سامانه مدیریت نشریات علمی, 46, 5, 1400, 355-363. doi: 10.30476/ijms.2020.81973.0
Mousavi, Azamsadat, Modarres Gilani, Mitra, Akhavan, Setareh, Sheikh Hasani, Shahrzad, Alipour, Abbas, Gholami, Hamideh. (1400). 'The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery', سامانه مدیریت نشریات علمی, 46(5), pp. 355-363. doi: 10.30476/ijms.2020.81973.0
Mousavi, Azamsadat, Modarres Gilani, Mitra, Akhavan, Setareh, Sheikh Hasani, Shahrzad, Alipour, Abbas, Gholami, Hamideh. The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery. سامانه مدیریت نشریات علمی, 1400; 46(5): 355-363. doi: 10.30476/ijms.2020.81973.0

The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery

Iranian Journal of Medical Sciences
مقاله 5، دوره 46، شماره 5، آذر 2021، صفحه 355-363    اصل مقاله (474.7 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.81973.0
نویسندگان
Azamsadat Mousavi1؛ Mitra Modarres Gilani1؛ Setareh Akhavan1؛ Shahrzad Sheikh Hasani1؛ Abbas Alipour2؛ Hamideh Gholami* 3
1Department of Oncology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3MD, Fellowship of Gyneco-oncology – Assistant professor of Zanjan University of Medical Sciences.
چکیده
Background: In recent years, before radical hysterectomy, neoadjuvant chemotherapy (NACT) has been administered to patients with locally advanced cervical cancer to shrink large tumors. It has been reported that this treatment significantly reduces the need for radiotherapy after surgery. The current study aimed to assess the outcome (survival, recurrence, and the need for adjuvant radiotherapy) of locally advanced cervical cancer in patients treated with NACT followed by radical hysterectomy and primary surgery.
Methods: In a retrospective cohort study, the records of 258 patients with cervical cancer (stage IB2, IIA, or IIB), who referred to Imam Khomeini Hospital (Tehran, Iran) from 2007 to 2017 were evaluated. The patients were assigned into two groups; group A (n=58) included patients, who underwent radical hysterectomy and group B (n=44) included those, who underwent a radical hysterectomy after NACT. The outcome measures were the recurrence rate, five-year survival rate, and the need for adjuvant radiotherapy.
Results: The median for overall survival time in group A and B was 113.65 and 112.88 months, respectively (P=0.970). There was no recurrence among patients with stage IB2 cervical cancer in group B, while the recurrence rate in group A was 19.5% with a median recurrence time of 59.13 months. Lymph node involvement was the only factor that affected patients’ survival. The need for postoperative adjuvant radiotherapy in group B was lower than in group A (P=0.002).
Conclusion: NACT before the hysterectomy was found to reduce the need for postoperative radiotherapy in patients with locally advanced cervical cancer according to disease stages. As a direct result, adverse side effects and the recurrence rate were reduced, and the overall survival rate of patients with stage IIB cervical cancer was increased.
کلیدواژه‌ها
Uterine cervical neoplasms؛ Hysterectomy؛ Recurrence؛ Survival
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مراجع
  1. Osman M. The role of neoadjuvant chemotherapy in the management of locally advanced cervix cancer: a systematic review. Oncol Rev. 2014;8:250. doi: 10.4081/oncol.2014.250. PubMed PMID: 25992238; PubMed Central PMCID: PMCPMC4419645.
  2. Momenimovahed Z, Salehiniya H. Cervical cancer in Iran: integrative insights of epidemiological analysis. Biomedicine (Taipei). 2018;8:18. doi: 10.1051/bmdcn/2018080318. PubMed PMID: 30141405; PubMed Central PMCID: PMCPMC6108227.
  3. Berek JS. Berek and Novak’s Gynecology. 15th ed. Philadelphia: Lippincott Williams and Wilkins; 2012. p. 1309-31.
  4. Rydzewska L, Tierney J, Vale CL, Symonds PR. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. Cochrane Database Syst Rev. 2012;12:CD007406. doi: 10.1002/14651858.CD007406.pub3. PubMed PMID: 23235641; PubMed Central PMCID: PMCPMC7175775.
  5. Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta-analysis C. Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data from 21 randomised trials. Eur J Cancer. 2003;39:2470-86. doi: 10.1016/s0959-8049(03)00425-8. PubMed PMID: 14602133.
  6. Cai HB, Chen HZ, Yin HH. Randomized study of preoperative chemotherapy versus primary surgery for stage IB cervical cancer. J Obstet Gynaecol Res. 2006;32:315-23. doi: 10.1111/j.1447-0756.2006.00404.x. PubMed PMID: 16764623.
  7. Eddy GL, Bundy BN, Creasman WT, Spirtos NM, Mannel RS, Hannigan E, et al. Treatment of (“bulky”) stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: a phase III trial of the gynecologic oncology group. Gynecol Oncol. 2007;106:362-9. doi: 10.1016/j.ygyno.2007.04.007. PubMed PMID: 17493669.
  8. Wang Y, Wang G, Wei LH, Huang LH, Wang JL, Wang SJ, et al. Neoadjuvant chemotherapy for locally advanced cervical cancer reduces surgical risks and lymph-vascular space involvement. Chin J Cancer. 2011;30:645-54. doi: 10.5732/cjc.011.10050. PubMed PMID: 21880186; PubMed Central PMCID: PMCPMC4013327.
  9. Di Donato V, Schiavi MC, Ruscito I, Visentin VS, Palaia I, Marchetti C, et al. Effects of Neoadjuvant Chemotherapy Plus Radical Surgery as Front Line Treatment Strategy in Patients Affected by FIGO Stage III Cervical Cancer. Ann Surg Oncol. 2016;23:841-9. doi: 10.1245/s10434-016-5597-1. PubMed PMID: 27678502.
  10. Papadia A, Bellati F, Bogani G, Ditto A, Martinelli F, Lorusso D, et al. When Does Neoadjuvant Chemotherapy Really Avoid Radiotherapy? Clinical Predictors of Adjuvant Radiotherapy in Cervical Cancer. Ann Surg Oncol. 2015;22 Suppl 3:S944-51. doi: 10.1245/s10434-015-4799-2. PubMed PMID: 26268452.
  11. Kim HS, Sardi JE, Katsumata N, Ryu HS, Nam JH, Chung HH, et al. Efficacy of neoadjuvant chemotherapy in patients with FIGO stage IB1 to IIA cervical cancer: an international collaborative meta-analysis. Eur J Surg Oncol. 2013;39:115-24. doi: 10.1016/j.ejso.2012.09.003. PubMed PMID: 23084091.
  12. Kokka F, Bryant A, Brockbank E, Powell M, Oram D. Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. Cochrane Database Syst Rev. 2015:CD010260. doi: 10.1002/14651858.CD010260.pub2. PubMed PMID: 25847525.
  13. Lee J, Kim TH, Kim GE, Keum KC, Kim YB. Neoadjuvant chemotherapy followed by surgery has no therapeutic advantages over concurrent chemoradiotherapy in International Federation of Gynecology and Obstetrics stage IB-IIB cervical cancer. J Gynecol Oncol. 2016;27:e52. doi: 10.3802/jgo.2016.27.e52. PubMed PMID: 27329200; PubMed Central PMCID: PMCPMC4944019.
  14. Angioli R, Plotti F, Montera R, Aloisi A, Luvero D, Capriglione S, et al. Neoadjuvant chemotherapy plus radical surgery followed by chemotherapy in locally advanced cervical cancer. Gynecol Oncol. 2012;127:290-6. doi: 10.1016/j.ygyno.2012.07.104. PubMed PMID: 22819938.
  15. Luvero D, Plotti F, Aloisi A, Capriglione S, Ricciardi R, Miranda A, et al. Patients treated with neoadjuvant chemotherapy + radical surgery + adjuvant chemotherapy in locally advanced cervical cancer: long-term outcomes, survival and prognostic factors in a single-center 10-year follow-up. Med Oncol. 2016;33:110. doi: 10.1007/s12032-016-0830-0. PubMed PMID: 27577931.
  16. Gong L, Lou JY, Wang P, Zhang JW, Liu H, Peng ZL. Clinical evaluation of neoadjuvant chemotherapy followed by radical surgery in the management of stage IB2-IIB cervical cancer. Int J Gynaecol Obstet. 2012;117:23-6. doi: 10.1016/j.ijgo.2011.11.017. PubMed PMID: 22265255.
  17. Chen H, Liang C, Zhang L, Huang S, Wu X. Clinical efficacy of modified preoperative neoadjuvant chemotherapy in the treatment of locally advanced (stage IB2 to IIB) cervical cancer: randomized study. Gynecol Oncol. 2008;110:308-15. doi: 10.1016/j.ygyno.2008.05.026. PubMed PMID: 18606439.
  18. Chemoradiotherapy for Cervical Cancer Meta-Analysis C. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol. 2008;26:5802-12. doi: 10.1200/JCO.2008.16.4368. PubMed PMID: 19001332; PubMed Central PMCID: PMCPMC2645100.
  19. Fu Y, Zhu T, Li H. Effectiveness of cervical cancer therapy using neoadjuvant chemotherapy in combination with radical surgery: a meta-analysis. Translational Cancer Research. 2017;6:228-37. doi: 10.21037/tcr.2017.01.06.
  20. Landoni F, Sartori E, Maggino T, Zola P, Zanagnolo V, Cosio S, et al. Is there a role for postoperative treatment in patients with stage Ib2-IIb cervical cancer treated with neo-adjuvant chemotherapy and radical surgery? An Italian multicenter retrospective study. Gynecol Oncol. 2014;132:611-7. doi: 10.1016/j.ygyno.2013.12.010. PubMed PMID: 24342439.
  21. Robova H, Rob L, Halaska MJ, Pluta M, Skapa P, Strnad P, et al. High-dose density neoadjuvant chemotherapy in bulky IB cervical cancer. Gynecol Oncol. 2013;128:49-53. doi: 10.1016/j.ygyno.2012.10.002. PubMed PMID: 23063763.s
  22. Marchetti C, De Felice F, Di Pinto A, Romito A, Musella A, Palaia I, et al. Survival Nomograms after Curative Neoadjuvant Chemotherapy and Radical Surgery for Stage IB2-IIIB Cervical Cancer. Cancer Res Treat. 2018;50:768-76. doi: 10.4143/crt.2017.141. PubMed PMID: 28724282; PubMed Central PMCID: PMCPMC6056954.
  23. Benedetti-Panici P, Greggi S, Colombo A, Amoroso M, Smaniotto D, Giannarelli D, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J Clin Oncol. 2002;20:179-88. doi: 10.1200/JCO.2002.20.1.179. PubMed PMID: 11773168.
  24. He L, Wu L, Su G, Wei W, Liang L, Han L, et al. The efficacy of neoadjuvant chemotherapy in different histological types of cervical cancer. Gynecol Oncol. 2014;134:419-25. doi: 10.1016/j.ygyno.2014.06.001. PubMed PMID: 24918866.
  25. Li R, Lu ST, Si JG, Liu B, Wang H, Mei YY, et al. Prognostic value of responsiveness of neoadjuvant chemotherapy before surgery for patients with stage IB(2)/IIA(2) cervical cancer. Gynecol Oncol. 2013;128:524-9. doi: 10.1016/j.ygyno.2012.11.006. PubMed PMID: 23146686.
  26. Namkoong SE, Park JS, Kim JW, Bae SN, Han GT, Lee JM, et al. Comparative study of the patients with locally advanced stages I and II cervical cancer treated by radical surgery with and without preoperative adjuvant chemotherapy. Gynecol Oncol. 1995;59:136-42. doi: 10.1006/gyno.1995.1280. PubMed PMID: 7557599.
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