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Mousavi, Azamsadat, Modarres Gilani, Mitra, Akhavan, Setareh, Sheikh Hasani, Shahrzad, Alipour, Abbas, Gholami, Hamideh. (1400). The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery. سامانه مدیریت نشریات علمی, 46(5), 355-363. doi: 10.30476/ijms.2020.81973.0
Azamsadat Mousavi; Mitra Modarres Gilani; Setareh Akhavan; Shahrzad Sheikh Hasani; Abbas Alipour; Hamideh Gholami. "The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery". سامانه مدیریت نشریات علمی, 46, 5, 1400, 355-363. doi: 10.30476/ijms.2020.81973.0
Mousavi, Azamsadat, Modarres Gilani, Mitra, Akhavan, Setareh, Sheikh Hasani, Shahrzad, Alipour, Abbas, Gholami, Hamideh. (1400). 'The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery', سامانه مدیریت نشریات علمی, 46(5), pp. 355-363. doi: 10.30476/ijms.2020.81973.0
Mousavi, Azamsadat, Modarres Gilani, Mitra, Akhavan, Setareh, Sheikh Hasani, Shahrzad, Alipour, Abbas, Gholami, Hamideh. The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery. سامانه مدیریت نشریات علمی, 1400; 46(5): 355-363. doi: 10.30476/ijms.2020.81973.0

The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery

Iranian Journal of Medical Sciences
مقاله 5، دوره 46، شماره 5، آذر 2021، صفحه 355-363    اصل مقاله (474.7 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.81973.0
نویسندگان
Azamsadat Mousavi1؛ Mitra Modarres Gilani1؛ Setareh Akhavan1؛ Shahrzad Sheikh Hasani1؛ Abbas Alipour2؛ Hamideh Gholami* 3
1Department of Oncology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3MD, Fellowship of Gyneco-oncology – Assistant professor of Zanjan University of Medical Sciences.
چکیده
Background: In recent years, before radical hysterectomy, neoadjuvant chemotherapy (NACT) has been administered to patients with locally advanced cervical cancer to shrink large tumors. It has been reported that this treatment significantly reduces the need for radiotherapy after surgery. The current study aimed to assess the outcome (survival, recurrence, and the need for adjuvant radiotherapy) of locally advanced cervical cancer in patients treated with NACT followed by radical hysterectomy and primary surgery.
Methods: In a retrospective cohort study, the records of 258 patients with cervical cancer (stage IB2, IIA, or IIB), who referred to Imam Khomeini Hospital (Tehran, Iran) from 2007 to 2017 were evaluated. The patients were assigned into two groups; group A (n=58) included patients, who underwent radical hysterectomy and group B (n=44) included those, who underwent a radical hysterectomy after NACT. The outcome measures were the recurrence rate, five-year survival rate, and the need for adjuvant radiotherapy.
Results: The median for overall survival time in group A and B was 113.65 and 112.88 months, respectively (P=0.970). There was no recurrence among patients with stage IB2 cervical cancer in group B, while the recurrence rate in group A was 19.5% with a median recurrence time of 59.13 months. Lymph node involvement was the only factor that affected patients’ survival. The need for postoperative adjuvant radiotherapy in group B was lower than in group A (P=0.002).
Conclusion: NACT before the hysterectomy was found to reduce the need for postoperative radiotherapy in patients with locally advanced cervical cancer according to disease stages. As a direct result, adverse side effects and the recurrence rate were reduced, and the overall survival rate of patients with stage IIB cervical cancer was increased.
کلیدواژه‌ها
Uterine cervical neoplasms؛ Hysterectomy؛ Recurrence؛ Survival
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مراجع
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