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Ouyang, Hong, Cheng, Jie, Du, Jingdong, Gan, Huiyun, Lu, Zheng. (1399). Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis. سامانه مدیریت نشریات علمی, 17(4), 275-282. doi: 10.22034/iji.2020.84871.1675
Hong Ouyang; Jie Cheng; Jingdong Du; Huiyun Gan; Zheng Lu. "Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis". سامانه مدیریت نشریات علمی, 17, 4, 1399, 275-282. doi: 10.22034/iji.2020.84871.1675
Ouyang, Hong, Cheng, Jie, Du, Jingdong, Gan, Huiyun, Lu, Zheng. (1399). 'Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis', سامانه مدیریت نشریات علمی, 17(4), pp. 275-282. doi: 10.22034/iji.2020.84871.1675
Ouyang, Hong, Cheng, Jie, Du, Jingdong, Gan, Huiyun, Lu, Zheng. Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis. سامانه مدیریت نشریات علمی, 1399; 17(4): 275-282. doi: 10.22034/iji.2020.84871.1675

Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis

Iranian Journal of Immunology
مقاله 2، دوره 17، شماره 4، اسفند 2020، صفحه 275-282    اصل مقاله (337.18 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2020.84871.1675
نویسندگان
Hong Ouyang؛ Jie Cheng* ؛ Jingdong Du؛ Huiyun Gan؛ Zheng Lu
Department of Otolaryngology, RenHe Hospital of Three Gorges University, Yichang, Hubei, China
چکیده
Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR). IL-27, an anti-inflammatory cytokine, has been reported to promote the production of IL-12R and induce Th1 cell responses. However, its effect on Th17 responses was not fully understood. Objective: We conducted the present research to explore the role of IL-27 in the regulation of Th17 responses in AR. Methods: Thirty confirmed AR patients and 20 controls were recruited for the study. The mRNA expression and protein levels of IL-27 were analyzed employing quantitative PCR (qPCR) and enzyme-linked immunosorbent assay (ELISA), respectively, and their correlations with Th17 cytokines were analyzed. We utilized ELISA and qPCR to analyze the effect of IL-27 on the differentiation of Th17 cells and the production of IL-17 and IL-23 from peripheral blood mononuclear cells (PBMCs). Results: We found that the IL-27 levels in AR were downregulated and negatively related to IL-17 and IL-23 levels. The recombinant IL-27 inhibited the mRNA expression of RORγt and the protein expression of IL-17 and IL-23 in PBMCs through MEK, NF-κB, and JNK pathways. Conclusion: Our data demonstrated that IL-27 suppressed Th17 responses through MEK, NF-κB, and JNK pathways.
کلیدواژه‌ها
Allergic Rhinitis؛ IL-17؛ IL-27؛ Peripheral Blood Mononuclear Cell؛ Th17
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