پیوندهای مفید
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| تعداد دریافت فایل اصل مقاله | 12,916,250 |
DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System | ||
| Iranian Journal of Immunology | ||
| مقاله 1، دوره 17، شماره 4، اسفند 2020، صفحه 255-274 اصل مقاله (666.24 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2020.87480.1806 | ||
| نویسنده | ||
| Ahmad Mobed* | ||
| 1 Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, 5166615556, Iran. 2Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| چکیده | ||
| Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB. Despite the protective effect of this vaccine in children, its efficiency remains under question in adults. We conducted the present study to provide an overview of DNA based vaccines against TB and highlight the vaccine delivery advances and limitations. This study also aimed to bring a review of mycobacterial antigens, including heat shock protein 65 (Hsp65), antigen 85A (Ag85A), early secretory antigenic target 6 (EAST-6), antigen 85B (Ag85B), and heat shock protein X (HspX) as the most extensively considered antigens in the development of vaccines against M. tuberculosis. | ||
| کلیدواژه‌ها | ||
| DNA Vaccine؛ Mycobacterium Tuberculosis؛ Mycobacterial Antigen؛ Vaccine Delivery | ||
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آمار تعداد مشاهده مقاله: 1,558 تعداد دریافت فایل اصل مقاله: 1,114 |
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