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Relationship between Clinicopathologic Features and Recurrence in Ovarian Germ Cell Tumor | ||
| Middle East Journal of Cancer | ||
| مقاله 10، دوره 12، شماره 3 - شماره پیاپی 47، مهر 2021، صفحه 399-405 اصل مقاله (128.75 K) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2020.83404.1160 | ||
| نویسندگان | ||
| Mozhdeh Momtahan1؛ Mojgan Akbarzadeh-Jahromi2؛ Saeid Jokar3؛ Shaghayegh Moradi-Alamdarloo1؛ Fatemeh Sari Aslani2؛ Maryam Rohani* 4 | ||
| 1Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran | ||
| 4Department of Obstetrics and Gynecology, Yasuj University of Medical Sciences, Yasuj, Iran | ||
| چکیده | ||
| Background: We conducted the present study to analyze the clinicopathologic features of patients with malignant ovarian germ cell tumor (MOGCT) with recurrence after 2 and 5 years. Method: In this retrospective and analytical-descriptive study, the obtained data included: age, tumor size, histopathological type, tumor stage, lymph node involvement, laterality of tumor, tumor necrosis, and mitosis. We also evaluated the Cox Regression analysis between these variables with recurrence after 2 and 5 years. Results: According to our exclusion criteria, we eliminated 81 cases. These cases consisted of the subjects with dysgerminoma (48.1%), immature teratoma (22.2%), yolk sac (16%), mix germ cell (11.1%), non-gestational choriocarcinoma (1.2%), and embryonal carcinoma (1.2%). We did not observe pure polyembryoma or polyembryoma in combination with mixed germ cell. All the patients received the treatment. The patients’ mean age was 23.3±8.4 years. MOGCT reoccurred in 10 patients after 2 years and in 13 patients after 5 years (10 cases in the first 2 years, and 3 new cases in the next 3 years). Most of the cases (64.2%) were diagnosed to be at stage 1. The Cox regression analysis between positive lymph node and the recurrence of MOGCT after 2 years and between stage IV of disease and the recurrence after 2 years were significant. The Cox regression analysis between laterality, mitosis and necrosis in pathologic slides of the recurrence after 2 and 5 years was not significant. Conclusion: Stages and involvement of lymph nodes are two major factors concerning the recurrence of MOGCT. Most recurrences occur in the first 2 years. Pathologic features (mitosis and necrosis) of MOGCt in the time of diagnosis not correlated with the recurrence of the disease. | ||
| کلیدواژه‌ها | ||
| Clinicopathologic؛ Ovarian germ cell tumor؛ Recurrence, Prognosis | ||
| اصل مقاله | ||
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How to cite this article: Momtahan M, Akbarzadeh- Jahromi M, Jokar S, Moradi-Alamdarloo S, Sari Aslani F, Rohani M. Relationship between clinicopathologic features and recurrence in ovarian germ cell tumor. Middle East J Cancer. 2021;12(3):399-405. doi: 10. 30476/mejc.2020.83404.1160. | ||
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