LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,113
تعداد مقالات10,208
تعداد مشاهده مقاله40,780,153
تعداد دریافت فایل اصل مقاله8,803,936
Veselinova Velikova, Tsvetelina, Angelova Spassova, Zoya, Mitkov Milatchkov, Lyuben, Georgieva Panova, Dobriana, Ivanova - Todorova, Ekaterina Ivanova, Tumangelova - Yuzeir, Kalina Dinkova, Kurteva, Ekaterina Krasimirova, Kyurkchiev, Dobroslav Stanimirov, Deredjan, Siragan Arshavir, Kirilov Nikolov, Rosen, Petrova Altankova, Iskra, Vladimirova, Lyudmila Mateva. (1396). Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease. سامانه مدیریت نشریات علمی, 6(1), -.
Tsvetelina Veselinova Velikova; Zoya Angelova Spassova; Lyuben Mitkov Milatchkov; Dobriana Georgieva Panova; Ekaterina Ivanova Ivanova - Todorova; Kalina Dinkova Tumangelova - Yuzeir; Ekaterina Krasimirova Kurteva; Dobroslav Stanimirov Kyurkchiev; Siragan Arshavir Deredjan; Rosen Kirilov Nikolov; Iskra Petrova Altankova; Lyudmila Mateva Vladimirova. "Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease". سامانه مدیریت نشریات علمی, 6, 1, 1396, -.
Veselinova Velikova, Tsvetelina, Angelova Spassova, Zoya, Mitkov Milatchkov, Lyuben, Georgieva Panova, Dobriana, Ivanova - Todorova, Ekaterina Ivanova, Tumangelova - Yuzeir, Kalina Dinkova, Kurteva, Ekaterina Krasimirova, Kyurkchiev, Dobroslav Stanimirov, Deredjan, Siragan Arshavir, Kirilov Nikolov, Rosen, Petrova Altankova, Iskra, Vladimirova, Lyudmila Mateva. (1396). 'Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease', سامانه مدیریت نشریات علمی, 6(1), pp. -.
Veselinova Velikova, Tsvetelina, Angelova Spassova, Zoya, Mitkov Milatchkov, Lyuben, Georgieva Panova, Dobriana, Ivanova - Todorova, Ekaterina Ivanova, Tumangelova - Yuzeir, Kalina Dinkova, Kurteva, Ekaterina Krasimirova, Kyurkchiev, Dobroslav Stanimirov, Deredjan, Siragan Arshavir, Kirilov Nikolov, Rosen, Petrova Altankova, Iskra, Vladimirova, Lyudmila Mateva. Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease. سامانه مدیریت نشریات علمی, 1396; 6(1): -.

Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease

Iranian Journal of Colorectal Research
دوره 6، شماره 1، خرداد 2018    اصل مقاله (284.99 K)
نوع مقاله: Research/Original Article
نویسندگان
Tsvetelina Veselinova Velikova* 1؛ Zoya Angelova Spassova2؛ Lyuben Mitkov Milatchkov2؛ Dobriana Georgieva Panova2؛ Ekaterina Ivanova Ivanova - Todorova3؛ Kalina Dinkova Tumangelova - Yuzeir3؛ Ekaterina Krasimirova Kurteva3؛ Dobroslav Stanimirov Kyurkchiev3؛ Siragan Arshavir Deredjan2؛ Rosen Kirilov Nikolov2؛ Iskra Petrova Altankova1؛ Lyudmila Mateva Vladimirova2
1Clinical Immunology, University Hospital Lozenetz, Sofia, Bulgaria
2Clinic of Gastroenterology, University Hospital St. Ivan Rilski, Sofia, Bulgaria
3Department of Clinical Laboratory and Clinical Immunology, University Hospital St. Ivan Rilski, Sofia, Bulgaria
چکیده
Background: Fecal and immunological biomarkers can be used to diagnose and manage patients with Crohn’s disease (CD). Anti -
tumor necrosis factor (TNF) should be evaluated in addition to biomarkers to determine the response to therapy.
Objectives: The current study aimed at following up fecal calprotectin (FC), perinuclear anti - neutrophil cytoplasmic antibodies
(pANCA), anti - Saccharomyces cerevisiae antibodies (ASCA), and anti - nuclear antibodies (ANA) in patients with CD on anti-TNF
therapy.
Methods: A total of 57 patients with CD and the mean age of 4015 years (ranged: 20 - 75) were monitored after initiation of anti
- TNFa treatment. Stool samples were tested for FC (Alegria automated the enzyme - linked immunosorbent assay (ELISA) system),
and serum samples for ANCA, ANA (indirect immunofluorescence - IIF), and ASCA (ELISA) in the beginning and after six months on
immunosuppressive therapy plus anti - TNFa agents.
Results: Itwasobserved that all patients withCDhadsignificantly decreased FC levels after anti -TNFatherapy (963.97mg/kginitially
vs. 268.42 mg/kg after treatment; P = 0.043). Moreover, in 75% of patients, FC levels dropped below the cutoff value of 50 mg/kg.
Positive for ASCAIgA/IgG were 17/24 tested patients, butnodifferences were observed regarding the application of anti - TNFa therapy.
However, the titers of pANCA decreased in four patients after anti - TNFa treatment.
Conclusions: Initial and follow - up measurements of some immunological markers such as FC and pANCA could be of benefit for
patients with CD in anti - TNF therapy, whereas others such as ANA and ASCA were not useful to monitor the therapy.

کلیدواژه‌ها
TNFa Inhibitors؛ Immunological Biomarkers؛ Therapy Monitoring
آمار
تعداد مشاهده مقاله: 171
تعداد دریافت فایل اصل مقاله: 126


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب