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Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis | ||
| Iranian Journal of Colorectal Research | ||
| دوره 5، Issues 3-4، شهریور 2017 اصل مقاله (386.21 K) | ||
| نوع مقاله: Research/Original Article | ||
| نویسندگان | ||
| Mostafa Vaghari Tabari1، 2؛ Soheila Moein* 1، 2؛ Durdi Qujeq* 3، 4؛ Mehrdad Kashifard5؛ Javaad Shokri Shirvani5؛ Karimollah Hajian Tilaki6؛ Gholamreza Farshidfar2 | ||
| 1Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran | ||
| 2Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran | ||
| 3Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran | ||
| 4Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran | ||
| 5Department of Internal Medicine, Gastroenterology Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran | ||
| 6Departments of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran | ||
| چکیده | ||
| Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examine the relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients with ulcerative colitis. Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20 were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation coefficient test. P < 0.05 was considered statistically significant. Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitis in comparison with the healthy controls (P < 0.05). No significant correlation was observed between theMDAlevel and triglyceride, cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between HDL-C and MDA levels (r, -0.306; P < 0.05). Conclusions: The inverse correlation between HDL-C andMDAlevels can be regarded as an indicator of the protective role of HDL-C against lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparison with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis. | ||
| کلیدواژهها | ||
| Ulcerative Colitis Disease؛ HDL-C Level؛ MDA Level؛ Active and Inactive Disease | ||
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آمار تعداد مشاهده مقاله: 190 تعداد دریافت فایل اصل مقاله: 187 |
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