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| تعداد دریافت فایل اصل مقاله | 11,292,293 |
Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer | ||
| Iranian Journal of Colorectal Research | ||
| دوره 4، شماره 4، اسفند 2016 اصل مقاله (122.53 K) | ||
| نوع مقاله: Review Article | ||
| نویسندگان | ||
| Zahra Mojtahedi؛ Somayeh Rezaeifard؛ Zahra Faghih* | ||
| Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells. | ||
| کلیدواژهها | ||
| Colon Cancer؛ Microbiota؛ T Cells؛ Tregs؛ Th17 | ||
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آمار تعداد مشاهده مقاله: 172 تعداد دریافت فایل اصل مقاله: 111 |
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