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The Correlation Between Single Nucleotide Polymorphism Patterns and Colorectal Cancer in the Iranian Population | ||
Iranian Journal of Colorectal Research | ||
دوره 4، شماره 3، آذر 2016 اصل مقاله (156.78 K) | ||
نوع مقاله: Research/Original Article | ||
نویسندگان | ||
Mozhdeh Zamani1؛ Seyed Vahid Hosseini1؛ Pooneh Mokarram* 2، 3 | ||
1Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran | ||
2Gasteroenterohepatology Research Center, Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran | ||
3Department of Biochemistry, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran | ||
چکیده | ||
Context: The incidence of colorectal cancer has significantly increased in Iran during the last decade. Accumulating evidence suggests that there is a significant correlation between genetic variations such as polymorphisms and colorectal cancer. Therefore, identification of critical polymorphisms related to colorectal cancer can contribute to find individuals at high risk of CRC. Evidence Acquisition: The focus of this review was on published articles in English about the association between different single nucleotide polymorphisms and colorectal cancer in the Iranian population. Evidences were gathered by searching online medical databases including Google scholar, Pubmed, Scopus and Science Direct. Conclusions: Various single nucleotide polymorphisms of critical genes indicated significant association with colorectal cancer in the Iranian population. New polymorphism markers for high risk individuals have been recognized through further investigations to reduce the incidence and mortality of colorectal cancer. | ||
کلیدواژهها | ||
Single Nucleotide Polymorphism؛ Colorectal Cancer؛ Iranian Population | ||
آمار تعداد مشاهده مقاله: 171 تعداد دریافت فایل اصل مقاله: 138 |