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Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 دی 1399 اصل مقاله (301.82 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2020.86990.1222 | ||
| نویسندگان | ||
Sasi Kumar PKS   1؛ Sheeja Varghese2؛ Thanga Kumaran S3؛ Jaga Desaan N4؛ Lambo Daran G5
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| 1Dept. of Periodontics, JKKN Dental College and Hospital, Tamilnadu DrMGR Medical University, Chennai. | ||
| 2Dean & HOD, Dept. of Periodontics, Saveetha Dental College and Hospital, Chennai, Tamilnadu, India. | ||
| 3Dept. of Periodontics, JKKN Dental College and Hospital. | ||
| 4Dept. of Prosthodontics, JKKN Dental College and Hospital. | ||
| 5Dept. of Prosthodontics. Meenakshiammal Dental College | ||
| چکیده | ||
| Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation. Purpose: To evaluate whether Interleukin -17A gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients. Materials and Method: The quantitative case- control study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 1 diabetes patients (T1DM) with chronic periodontitis (CP), Group B: 15 T1DM patients without CP, Group C: 15 Non-diabetic patients with CP, Group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indicated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients. Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients. | ||
| کلیدواژه‌ها | ||
| IL-17A؛ Polymorphisms Type 1 Diabetes؛ Chronic Periodontitis؛ Ethnicity | ||
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آمار تعداد مشاهده مقاله: 176 تعداد دریافت فایل اصل مقاله: 61 |
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