پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,149 |
| تعداد مقالات | 10,518 |
| تعداد مشاهده مقاله | 45,415,982 |
| تعداد دریافت فایل اصل مقاله | 11,291,626 |
Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients | ||
| Journal of Dentistry | ||
| مقاله 5، دوره 22، شماره 3 - شماره پیاپی 72، آذر 2021، صفحه 180-186 اصل مقاله (209.05 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2020.86990.1222 | ||
| نویسندگان | ||
| Sasi Kumar PKS* 1؛ Sheeja Varghese2؛ Thanga Kumaran S3؛ Jaga Desaan N4؛ Lambo Daran G5 | ||
| 1Dept. of Periodontics, JKKN Dental College and Hospital, Tamilnadu DrMGR Medical University, Chennai. | ||
| 2Dean & HOD, Dept. of Periodontics, Saveetha Dental College and Hospital, Chennai, Tamilnadu, India. | ||
| 3Dept. of Periodontics, JKKN Dental College and Hospital. | ||
| 4Dept. of Prosthodontics, JKKN Dental College and Hospital. | ||
| 5Dept. of Prosthodontics. Meenakshiammal Dental College | ||
| چکیده | ||
| Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation. Purpose: To evaluate whether Interleukin -17A gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients. Materials and Method: The quantitative case- control study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 1 diabetes patients (T1DM) with chronic periodontitis (CP), Group B: 15 T1DM patients without CP, Group C: 15 Non-diabetic patients with CP, Group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indicated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients. Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients. | ||
| کلیدواژه‌ها | ||
| IL-17A؛ Polymorphisms Type 1 Diabetes؛ Chronic Periodontitis؛ Ethnicity | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
[1] Loesche WJ. Bacterial mediators in periodontal disease. Clin Infect Dis. 1993; 16: S203-S210.
[2] Slade GD, Offenbacher S, Beck JD, Heiss G, Pankow JS. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res. 2000; 79: 49-57.
[3] Hansen HB. Role of cytokines and inflammatory mediators in tissue destruction. J Perio Res. 1993; 28: 500–510.
[4] Takahashi K, Azuma T, Motohira H, Kinane DF, Kitetsu S. The potential role of interleukin-17 in the immuno pathology of periodontal disease. J Clin Periodontol. 2005; 32: 369–374.
[5] Cardoso CR, Garlet GP, Crippa GE, Rosa AL, Junior WM, Rossi MA, et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol. 2009; 24: 1-6.
[6] Azman R, Lappin DF, MacPherson A, Riggio M, Robertson D, Hodge P. et al. Clinical associations between IL-17 family cytokines and periodontal disease and potential differential roles for IL-17A and IL-17E in periodontal immunity. Inflamm Res. 2014; 63: 1001–1012.
[7] Shaker OG, Ghallab NA. IL-17 and IL-11 GCF levels in aggressive and chronic periodontitis patients: relation to PCR bacterial detection. Mediators Inflamm. 2012; 2012: 174764.
[8] Beklen A, Ainola M, Hukkanen M, Gurgan C, Sorsa T. MMPs, IL-1 and TNF are regulated by IL-17 in periodontitis. J Dent Res. 2007; 86: 347-351.
[9] Biswas PS, Kang K, Gupta S, Bhagat G, Pernis AB. A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21. Methods Mol Biol. 2012; 900: 233– 251.
[10] Ghaffari SA,Nemati M, Hajghani H, Ebrahimi H. Circulating concentrations of interleukin (IL)-17 in patients with multiple sclerosis: Evaluation of the effects of gender, treatment, disease patterns and IL-23 receptor gene polymorphisms. Iran J Neurol. 2017; 16: 15–25.
[11] Kurte M, Luz-Crawford P, Vega-Letter AM, Contreras RA, Tejedor G, Elizondo-Vega R, et al. IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018; 9: 802.
[12] Emamaullee JA, Davis J, Merani S, Toso C, Elliott JF, Thiesen A, et al. Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes. 2009; 58: 1302-1311.
[13] Honkanen J, Nieminen JK, Gao R, Luopajarvi K, Salo HM, Ilonen J, et al. IL-17 immunity in human type 1 diabetes. J Immunol. 2010; 185: 1959-1967.
[14] Arif S, Moore F, Marks K, Bouckenooghe T, Dayan CM, Planas R, et al. Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated-cell death. Diabetes. 2011; 60: 2112–2119.
[15] Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, et al. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009; 183: 4432–4439.
[16] Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab. 2007; 92: 3705–3711.
[17] Ozçaka O, Nalbantsoy A, Buduneli N. Interleukin-17 and interleukin-18 levels in saliva and plasma of patients with chronic periodontitis. J Periodontal Res. 2011; 46: 592-598.
[18] Shaker OG, Ghallab NA. IL-17 and IL-11 GCF Levels in Aggressive and Chronic Periodontitis Patients: Relation to PCR Bacterial Detection. Mediators of Inflammation. 2012; 2012: 1-7.
[19] Linhartova PB, Kastovsky J, Lucanova S, Bartova J. Poskerova H, Vokurka J, et al. Interleukin-17AGene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria. Mediators of Inflammation. 2016; 2016: 2979846.
[20] Saraiva AM, Alves de, Silva MRM, Correia-Silva JF, Costa JE, Collob KJ, et al. Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis. Hum Immunol. 2013; 74:207–214.
[21] Caton JG, Armitage G, Berglundh T, Chapple TC. A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Clin Periodontol. 2018; 45 Suppl 20: S1-S8.
[22] Loe H, Silness J. Periodontal disease in pregnancy. Acta Odontol Scand. 1963; 21: 533-551.
[23] Mohammadi A, Esmaeili N. Diabetes control and its relationship with HbA1c and blood sugar. J Qazvin Univ Med Sci. 2001; 4: 23–26.
[24] Zacarias JMV, de*Alencar JB, Tsuneto PY, de*Souza VH, Silva CO, Visentainer JEL, et al. The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study. Mediators Inflamm. 2019; 2019: 1–10.
[25] Chaudhari HL, Warad S, Ashok N, Baroudi K, Tarakji B. Association of Interleukin-17 polymorphism (-197G/ A) in chronic and localized aggressive periodontitis. Braz Oral Res. 2016; 30: 1–7.
[26] Espinoza JL, Takami A, Nakata K, Onizuka M, Kawase T, et al. A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. PLoS One. 2011; 6: e26229.
[27] Corrêa JD, Madeira MFM, Resende RG, Correia-Silva JF, Gomez RS, Souza DG, et al. Association between polymorphisms in interleukin-17A and -17F genes and chronic periodontal disease. Mediators Inflamm. 2015; 2015:1-8. | ||
|
آمار تعداد مشاهده مقاله: 2,767 تعداد دریافت فایل اصل مقاله: 1,777 |
||
