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Colorectal Cancer in Octogenarians: Results of Treatment, a Descriptive Clinical Study | ||
| Iranian Journal of Colorectal Research | ||
| دوره 4، شماره 2، شهریور 2016 اصل مقاله (310.61 K) | ||
| نوع مقاله: Research/Original Article | ||
| نویسندگان | ||
| Elmer van Eeghen؛ Sandra D. Bakker؛ Ruud JLF Loffeld* | ||
| Department of Internal Medicine, Zaans Medisch Centrum, Zaandam, The Netherlands | ||
| چکیده | ||
| Background: Colorectal cancers (CRCs) often occur in octogenarians. However, data on treatment and survival are sparse. Objectives: Octogenarians were studied in order to gain data on treatment, outcomes, and survival related to CRC. Patients and Methods: All consecutive octogenarians with CRC in the period of 2002 - 2008 were included. An extensive review of hospital records was carried out. Patients were divided into two groups, as follows: group 1 included patients who were alive after five years of follow-up, while group 2 comprised patients who died within 5 years of their diagnosis. Cause of death was determined and classified as related to cancer, non-related, or because of treatment. Results: Onehundredandeleven octogenarians were diagnosed withCRC(82 colon cancersand29 rectal cancers). Patients in group 2 had a significantly higher disease stage compared with group 1 (P < 0.001). Patients in group 1 more often underwent surgery with curative intent (P< 0.0001). There was no difference in clinical presentation or localization of themalignancy. In group 1, 14 patients died more than 5 years after surgery. The cause of death was not related to cancer in 100% of cases. In group 2, 29 (46.0%) died as a direct consequence of CRC, 14 (22.2%) due to the treatment, and 20 (31.7%) died due to non-cancer-related causes. The overall 5- year survival rate was 40% in colon cancer patients and 51.7% in rectal cancer patients. The Charlson age co-morbidity scores were significantly lower in colon cancer patients in group 1 (P = 0.005). This was not the case in patients with rectal cancer. Conclusions: The co-morbidity score is important in survival after surgery. Forty-four percent of octogenarians with CRC died because of non-tumor-related disease or illness. Fit elderly people can benefit from standard therapy for CRC. | ||
| کلیدواژهها | ||
| Octogenarians؛ Colorectal Cancer؛ Epidemiology؛ Survival؛ Recurrence | ||
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آمار تعداد مشاهده مقاله: 115 تعداد دریافت فایل اصل مقاله: 66 |
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