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Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic Drugs | ||
Journal of Biomedical Physics and Engineering | ||
مقاله 11، دوره 12، شماره 2، خرداد و تیر 2022، صفحه 205-210 اصل مقاله (568.69 K) | ||
نوع مقاله: Original Research | ||
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1256 | ||
نویسندگان | ||
Bahram Yousefian1؛ Seyed Mohammad Firoozabadi* 2؛ Manijhe Mokhtari-Dizaji2 | ||
1PhD, Department of Radiology, Faculty of Allied Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
2PhD, Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
چکیده | ||
Background: In the present study, we investigated the application of pulsed magnetic field (MF) (3.5 T, 1 Hz, 8 square-wave/160 µs) permeabilization on murine breast adenocarcinoma cells when administering bleomycin (BLM) in vivo. Objective: This cross-over study aims to find a noninvasive method to facilitate penetration of hydrophilic anti-cancer drugs through the cancerous cells membrane into the cytosoll in order to minimize the side effects of the chemotherapy treatments of tumors. Material and Methods: In this cross-over study, a total of 50 female Balb/c mice were tumorized via homograft. After about 2 weeks, magnetic pulses (3.5 T, 1 Hz, 8 square-wave/160 µs) were applied to tumor-bearing mice 3 min after intratumoral BLM solution injection. Tumor volume was measured every 48 h during 22 days. Results: The results showed that the difference between the BLM plus 3.5 T MF group versus the sham control or sham MF groups was significant. Uptake of BLM molecules by tumoral cells in the BLM plus 3.5 T MF group versus the BLM control group was 7- folds higher that this result was statistically insignificant (p <0.05, SEM=266.8676, analysis of variance). Conclusion: Significant cell permeabilization to BLM requires greater MF strength or exposure time. Further investigation is necessary. | ||
کلیدواژهها | ||
Chemotherapy؛ Magnetic Fields؛ Permeabilization؛ In Vivo؛ Bleomycin؛ Balb/C؛ Adenocarcinoma | ||
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