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Kazemian, Ali, Ghalehtaki, Reza, Razmkhah, Mahdieh, Taheriyoun, Maryam, Mohammadi, Negin, Narimani Kali, Mohammad, Farhan, Farshid, Aghili, Mahdi, Esmati, Ebrahim. (1401). Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran. سامانه مدیریت نشریات علمی, 13(2), 308-315. doi: 10.30476/mejc.2020.87158.1404
Ali Kazemian; Reza Ghalehtaki; Mahdieh Razmkhah; Maryam Taheriyoun; Negin Mohammadi; Mohammad Narimani Kali; Farshid Farhan; Mahdi Aghili; Ebrahim Esmati. "Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran". سامانه مدیریت نشریات علمی, 13, 2, 1401, 308-315. doi: 10.30476/mejc.2020.87158.1404
Kazemian, Ali, Ghalehtaki, Reza, Razmkhah, Mahdieh, Taheriyoun, Maryam, Mohammadi, Negin, Narimani Kali, Mohammad, Farhan, Farshid, Aghili, Mahdi, Esmati, Ebrahim. (1401). 'Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran', سامانه مدیریت نشریات علمی, 13(2), pp. 308-315. doi: 10.30476/mejc.2020.87158.1404
Kazemian, Ali, Ghalehtaki, Reza, Razmkhah, Mahdieh, Taheriyoun, Maryam, Mohammadi, Negin, Narimani Kali, Mohammad, Farhan, Farshid, Aghili, Mahdi, Esmati, Ebrahim. Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran. سامانه مدیریت نشریات علمی, 1401; 13(2): 308-315. doi: 10.30476/mejc.2020.87158.1404

Definitive Radiotherapy with or without Concomitant or Induction Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single Center Study in Iran

Middle East Journal of Cancer
مقاله 12، دوره 13، شماره 2 - شماره پیاپی 50، تیر 2022، صفحه 308-315    اصل مقاله (525.16 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.87158.1404
نویسندگان
Ali Kazemian1؛ Reza Ghalehtaki* 1، 2؛ Mahdieh Razmkhah2؛ Maryam Taheriyoun2؛ Negin Mohammadi1؛ Mohammad Narimani Kali3؛ Farshid Farhan2؛ Mahdi Aghili1؛ Ebrahim Esmati2
1Radiation Oncology Research Center (RORC), Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Hypopharyngeal carcinoma (HPC) is a rare head and neck cancer which poses many therapeutic challenges. There is limited evidence regarding the outcomes of HPC treatment in Iran.
Method: In this retrospective cohort study, we evaluated patients treated with chemoradiation or radiation alone, between 2007 and 2016 in the radiation oncology ward of the cancer institute affiliated to Tehran University of Medical Sciences. The design of the study was reviewed and approved by the local institutional review board (code: 86100142). All patients underwent definitive radiotherapy with or without concurrent or sequential chemotherapy. We assessed the two-year overall survival (OS) as the primary outcome. The progression-free survival (PFS) was our secondary outcome.
Results: We studied 40 patients whose median age was 58 years. 37 patients were stage 3 or 4, while the most common stage was T3N1-2, observed in 35% of the cases. The most common site of involvement was pyriform sinus (47.5%). The twoyear OS rate was 29%. The two-year PFS was 22%. In the univariate analysis, N0-1 vs. N 2-3 and stage 2 vs. stage 3-4 were significant predictors of OS. In addition, distant metastasis had almost a significant association with lower OS.
Conclusion: The outcome of locally advanced HPC was not promising using 3DCRT alone. It is necessary to implement dramatic changes in the management of these patients to achieve better outcomes.
کلیدواژه‌ها
Hypopharyngeal neoplasms؛ Head and neck cancer؛ Radiotherapy؛ Concurrent chemotherapy؛ Squamous cell carcinoma
اصل مقاله

How to cite this article:

Kazemian A, Ghalehtaki R, Razmkhah M, Taheriyoun M, Mohammadi N, Narimani Kali M, et al. Definitive radiotherapy with or without concomitant or induction chemotherapy in patients with hypopharyngeal squamous cell carcinoma: a single center study in Iran. Middle East J Cancer. 2022;13(2):308-15. doi: 10.30476/mejc.2020.87158.1404.

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