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Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis | ||
Middle East Journal of Cancer | ||
مقاله 1، دوره 12، شماره 2 - شماره پیاپی 46، تیر 2021، صفحه 161-171 اصل مقاله (2.68 M) | ||
نوع مقاله: Review Article(s) | ||
شناسه دیجیتال (DOI): 10.30476/mejc.2020.83099.1135 | ||
نویسندگان | ||
Vidyalakshmi Subramanian* 1؛ Xavier Joshna Catherine1؛ Rajeswari Murugesan2 | ||
1Department of Biotechnology, PSG College of Technology, Coimbatore, India | ||
2Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, India | ||
چکیده | ||
Background: We conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients. Method: For the determination of the pooled hazard ratio (HR) values based on the fixed- effects model, in this retrospective study, we employed comprehensive meta-analysis software. Results: This retrospective analysis identified the expression patterns of 6645 patients in 36 studies. Expression of TWIST1 correlated with the least prognosis rate (HR= 2.129, 95% CI= 1.373 - 3.302) as compared to SNAIL1 (HR= 1.804, 95% CI= 1.151 - 2.827), SLUG (HR= 1.724, 95% CI= 0.992 - 2.997) and ZEB1 (HR= 1.590, 95% CI= 1.358 - 1.861). Conclusion: These findings suggested the implication of TWIST1 as an effective biomarker for an early tumor diagnosis and therapy for metastasis. | ||
کلیدواژهها | ||
Metastasis؛ EMT-TFs؛ Fixed effects model؛ Cancer prognosis؛ Biomarker | ||
اصل مقاله | ||
How to cite this article: Subramanian V, Catherine XJ, Murugesan R. Prognostic role of Emt-transcription factors in carcinoma- A systematic review and meta-analysis. Middle East J Cancer. 2021;12(2):161-71. doi:10.30476/mejc.2020.83099.1135. | ||
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