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Subramanian, Vidyalakshmi, Joshna Catherine, Xavier, Murugesan, Rajeswari. (1400). Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 12(2), 161-171. doi: 10.30476/mejc.2020.83099.1135
Vidyalakshmi Subramanian; Xavier Joshna Catherine; Rajeswari Murugesan. "Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis". سامانه مدیریت نشریات علمی, 12, 2, 1400, 161-171. doi: 10.30476/mejc.2020.83099.1135
Subramanian, Vidyalakshmi, Joshna Catherine, Xavier, Murugesan, Rajeswari. (1400). 'Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis', سامانه مدیریت نشریات علمی, 12(2), pp. 161-171. doi: 10.30476/mejc.2020.83099.1135
Subramanian, Vidyalakshmi, Joshna Catherine, Xavier, Murugesan, Rajeswari. Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 1400; 12(2): 161-171. doi: 10.30476/mejc.2020.83099.1135

Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis

Middle East Journal of Cancer
مقاله 1، دوره 12، شماره 2 - شماره پیاپی 46، تیر 2021، صفحه 161-171    اصل مقاله (2.68 M)
نوع مقاله: Review Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.83099.1135
نویسندگان
Vidyalakshmi Subramanian* 1؛ Xavier Joshna Catherine1؛ Rajeswari Murugesan2
1Department of Biotechnology, PSG College of Technology, Coimbatore, India
2Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, India
چکیده
Background: We conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients.
Method: For the determination of the pooled hazard ratio (HR) values based on the fixed- effects model, in this retrospective study, we employed comprehensive meta-analysis software.
Results: This retrospective analysis identified the expression patterns of 6645 patients in 36 studies. Expression of TWIST1 correlated with the least prognosis rate (HR= 2.129, 95% CI= 1.373 - 3.302) as compared to SNAIL1 (HR= 1.804, 95% CI= 1.151 - 2.827), SLUG (HR= 1.724, 95% CI= 0.992 - 2.997) and ZEB1 (HR= 1.590, 95% CI= 1.358 - 1.861).
Conclusion: These findings suggested the implication of TWIST1 as an effective biomarker for an early tumor diagnosis and therapy for metastasis.
کلیدواژه‌ها
Metastasis؛ EMT-TFs؛ Fixed effects model؛ Cancer prognosis؛ Biomarker
اصل مقاله

How to cite this article:

Subramanian V, Catherine XJ, Murugesan R. Prognostic role of Emt-transcription factors in carcinoma- A systematic review and meta-analysis. Middle East J Cancer. 2021;12(2):161-71. doi:10.30476/mejc.2020.83099.1135.

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