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Javaherforoosh Zadeh, Fatemeh, Janatmakan, Farahzad, Shafaeebejestan, Emad, Jorairahmadi, Sara. (1399). Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 46(2), 120-127. doi: 10.30476/ijms.2020.82860.1146
Fatemeh Javaherforoosh Zadeh; Farahzad Janatmakan; Emad Shafaeebejestan; Sara Jorairahmadi. "Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 46, 2, 1399, 120-127. doi: 10.30476/ijms.2020.82860.1146
Javaherforoosh Zadeh, Fatemeh, Janatmakan, Farahzad, Shafaeebejestan, Emad, Jorairahmadi, Sara. (1399). 'Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 46(2), pp. 120-127. doi: 10.30476/ijms.2020.82860.1146
Javaherforoosh Zadeh, Fatemeh, Janatmakan, Farahzad, Shafaeebejestan, Emad, Jorairahmadi, Sara. Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1399; 46(2): 120-127. doi: 10.30476/ijms.2020.82860.1146

Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 6، دوره 46، شماره 2، خرداد 2021، صفحه 120-127    اصل مقاله (500.1 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.82860.1146
نویسندگان
Fatemeh Javaherforoosh Zadeh* ؛ Farahzad Janatmakan؛ Emad Shafaeebejestan؛ Sara Jorairahmadi
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background: Patients undergoing cardiac surgery are particularly prone to delirium. This study aimed to evaluate the effect of melatonin administration on the inhibition of postoperative delirium in patients undergoing open-heart surgery.
Methods: This study was conducted as a double-blind randomized clinical trial in Golestan Hospital. Ahvaz, Iran, (September 2018 to March 2019). Sixty patients undergoing elective on-pump coronary artery bypass graft surgery were enrolled in the study, and they were randomly divided into a group receiving 3 mg of melatonin and a group receiving a placebo. The main outcomes were delirium occurrence and delirium intensity up to 48 hours after extubation. The data were analyzed using SPSS, version 22, (SPSS, Chicago, IL). Group comparisons were performed using the t test and the Chi-square test. Statistical significance was defined as a P value of less than 0.05.
Results: On the first postoperative day, delirium developed in four (13.3%) patients in the melatonin group and 11 (36.6%) patients in the control group; the difference between the groups was statistically significant (P=0.037). On the second postoperative day, delirium developed in three (10%) patients in the melatonin group and 14 (46.6%) patients in the control group, with the difference in the incidence of delirium between the groups constituting statistical significance (P=0.029). The severity of delirium between group was significant on the first and second postoperative days (P=0.003).
Conclusion: Melatonin may be effective in reducing the severity of delirium after cardiac surgery. The effect of melatonin as a delirium prevention agent should be considered in patients admitted in the cardiovascular intensive care.
Trial Registration Number: IRCT20180909040979N3.
کلیدواژه‌ها
Melatonin؛ Delirium؛ Thoracic surgery
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مراجع
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