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Phycocyanin C a Natural Product with Impressive Therapeutic Efficacy for Inhibition of Breast Tumors’ Growth and Metastasis in Vivo | ||
| Middle East Journal of Cancer | ||
| مقاله 12، دوره 12، شماره 2 - شماره پیاپی 46، تیر 2021، صفحه 261-268 اصل مقاله (1.83 M) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2020.83064.1130 | ||
| نویسندگان | ||
| Amirhosein Kefayat1؛ Mohadeseh Yuosefzadeh2؛ Parvin Goli2؛ Alireza Babayi3؛ Abbas Rezaei2؛ Nafiseh Esmaeil* 2 | ||
| 1Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 2Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 3Department of Biology, Payame Noor Isfahan University, Isfahan, Iran | ||
| چکیده | ||
| Background: Several studies have reported the anticancer effect of phycocyanin C, a natural extract isolated from the algae Arthrospira platensis. However, its therapeutic effects on the growth of breast cancer and its metastasis have not been determined yet. Method: In this case-control study, we employed phycocyanin C for the treatment of 4T1 breast tumor as an applicable experimental animal model for human mammary cancer and metastasis. BALB/c mice were injected subcutaneously (s.c) into the 4th abdominal mammary fat pad with 1×106 4T1 cells. We randomly divided the mice into two groups; one group of mice were injected with PBS as the control, and the other group was intraperitoneally injected with phycocyanin C (80 mg/kg daily for 20 days). Tumor growth and metastasis were assessed in both groups. Results: Phycocyanin C significantly inhibited 4T1 breast tumors growth (P<0.05). The mean tumors volumes at the control group were 2.73 times higher than those of the treatment group. In addition, phycocyanin C treatment could significantly inhibit the formation of metastasis colonies at vital organs like spleen, liver, and lung. Moreover, the survival rate of the tumor-bearing mice increased after about 22 days by phycocyanin C treatment in comparison with the control. Conclusion: This is the first report demonstrating the anticancer effects of phycocyanin C on 4T1 breast tumor in vivo. Overall, our findings provided convincing evidence for the application of phycocyanin C as an anticancer therapeutic agent. | ||
| کلیدواژه‌ها | ||
| Phycocyanin C؛ Breast neoplasm؛ Metastasis | ||
| اصل مقاله | ||
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How to cite this article: Kefayat A, Yuosefzadeh M, Goli P, Babayi A, Rezaei A, Esmaeil N. Phycocyanin C a natural product with impressive therapeutic efficacy for inhibition of breast tumors’ growth and metastasis in vivo. Middle East J Cancer. 2021;12(2): 261-8. doi: 10.30476/mejc.2020. 83064.1130. | ||
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