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Elfeky, Mariem, Harb, Ola, El Shafaay, Basant, Obaya, Ahmed, Awd, Amr, Alkilany, Mohamed, Gertallah, Loay. (1400). Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer. سامانه مدیریت نشریات علمی, 12(2), 172-182. doi: 10.30476/mejc.2020.82884.1115
Mariem A. Elfeky; Ola A. Harb; Basant Sh El Shafaay; Ahmed A. Obaya; Amr A. Awd; Mohamed M. Alkilany; Loay M. Gertallah. "Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer". سامانه مدیریت نشریات علمی, 12, 2, 1400, 172-182. doi: 10.30476/mejc.2020.82884.1115
Elfeky, Mariem, Harb, Ola, El Shafaay, Basant, Obaya, Ahmed, Awd, Amr, Alkilany, Mohamed, Gertallah, Loay. (1400). 'Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer', سامانه مدیریت نشریات علمی, 12(2), pp. 172-182. doi: 10.30476/mejc.2020.82884.1115
Elfeky, Mariem, Harb, Ola, El Shafaay, Basant, Obaya, Ahmed, Awd, Amr, Alkilany, Mohamed, Gertallah, Loay. Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer. سامانه مدیریت نشریات علمی, 1400; 12(2): 172-182. doi: 10.30476/mejc.2020.82884.1115

Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer

Middle East Journal of Cancer
مقاله 2، دوره 12، شماره 2 - شماره پیاپی 46، تیر 2021، صفحه 172-182    اصل مقاله (7.18 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.82884.1115
نویسندگان
Mariem A. Elfeky1؛ Ola A. Harb* 1؛ Basant Sh El Shafaay2؛ Ahmed A. Obaya2؛ Amr A. Awd3؛ Mohamed M. Alkilany4؛ Loay M. Gertallah4
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egyp
چکیده
Background: Evaluation of cancer cervix prognosis is highly needed for novel targeted therapy and improved outcomes. Nucleolar and spindle associated protein 1 (NUSAP1) is a novel biomarker that has roles in spindle formation and mitotic progression. Maternal embryonic leucine zipper kinase (MELK) is involved in cell cycle control and carcinogenesis. The L1 cell adhesion molecule (L1-CAM) plays an essential role in cell migration. This study aimed to investigate NUSAP1, MELK, and L1CAM immunohistochemical expression in cancer cervix tissues and detect their prognostic roles.
Method: In this prospective cohort study, we evaluated NUSAP1, MELK, and L1CAM expressions of sections from 62 cervical carcinoma cases using immunohistochemistry.
Results: NUSAP1, MELK, and L1CAM expression correlated with tumor high grade, advanced FIGO stage, poor survival rates, and higher recurrence rate after successful therapy (p <0.001).
Conclusion: Expression of NUSAP1, MELK, and L1CAM in cancer cervix was associated with poor prognosis.
کلیدواژه‌ها
Cancer cervix؛ Immunohistochemistry؛ Prognosis؛ NUSAP1؛ MELK؛ L1CAM
اصل مقاله

How to cite this article:

Elfeky M, Harb O, El Shafaay B, Obaya A, Awd A, Alkilany M, et al. Prognostic and clinicopathological implications of NUSAP1, MELK and L1CAM immunohistochemical expression in cervical cancer. Middle East J Cancer. 2021;12 (2):172-82. doi:10.30476/mejc. 2020.82884. 1115.

This article has been partically presented in BGICC-Breast Gynecological and Immuno-Oncology International Cancer Conference 2020 and published in Tumori Journal: Vol 106, Issue 1 - suppl, April 2020.

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