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Fatemi, Kazem, Rezaee, Seyed Abdolrahim, Banihashemrad, Seyed Ali, Keyvanfar, Sanaz, Eslami, Meghdad. (1399). Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients. سامانه مدیریت نشریات علمی, 17(3), 236-243. doi: 10.22034/iji.2020.81170.1512
Kazem Fatemi; Seyed Abdolrahim Rezaee; Seyed Ali Banihashemrad; Sanaz Keyvanfar; Meghdad Eslami. "Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients". سامانه مدیریت نشریات علمی, 17, 3, 1399, 236-243. doi: 10.22034/iji.2020.81170.1512
Fatemi, Kazem, Rezaee, Seyed Abdolrahim, Banihashemrad, Seyed Ali, Keyvanfar, Sanaz, Eslami, Meghdad. (1399). 'Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients', سامانه مدیریت نشریات علمی, 17(3), pp. 236-243. doi: 10.22034/iji.2020.81170.1512
Fatemi, Kazem, Rezaee, Seyed Abdolrahim, Banihashemrad, Seyed Ali, Keyvanfar, Sanaz, Eslami, Meghdad. Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients. سامانه مدیریت نشریات علمی, 1399; 17(3): 236-243. doi: 10.22034/iji.2020.81170.1512

Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients

Iranian Journal of Immunology
دوره 17، شماره 3، آذر 2020، صفحه 236-243    اصل مقاله (677.88 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2020.81170.1512
نویسندگان
Kazem Fatemi1؛ Seyed Abdolrahim Rezaee2؛ Seyed Ali Banihashemrad3؛ Sanaz Keyvanfar* 4؛ Meghdad Eslami3
1Department of periodontology, Faculty of dentistry, Mashhad university of medical science, Mashhad, Iran.
2Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , Iran.
3Department of Periodontology, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of periodontology, faculty of dentistry, Birjand University of Medical Sciences, Birjand, Iran. Dentistry Clinical Research Development Center, Birjand University of medical science, Birjand, Iran
چکیده
Background: Matrix metalloproteinases (MMPs) stimulate alveolar bone loss in chronic periodontitis. Objective: To evaluate the salivary and gingival crevicular fluid (GCF) levels of MMP-8 in patients with moderate to severe chronic periodontitis. Methods: 42 participants were divided into two groups: a case group (21 patients with generalized moderate to severe chronic periodontitis) and a control group (21 healthy periodontal subjects). GCF and saliva samples were obtained from both groups. Salivary and GCF MMP-8 levels of each subject were detected using the ELISA method. Results: Mean±SD values of salivary MMP-8 levels of the control and case groups were 1.52 ± 0.65 ng/ml and 6.06 ± 1.18 ng/ml, respectively, and statistically significant difference was observed (p=0.0001). Also, mean±SD values of GCF MMP-8 levels of the control and case groups were 0.87 ± 0.26 ng/ml and 2.92 ± 0.64 ng/ml, respectively; which was statistically significant (p=0.0001). Conclusion: Our results demonstrate an increased concentration of salivary and GCF levels of MMP-8 in the patient group.
کلیدواژه‌ها
Chronic Periodontitis؛ Crevicular Fluid؛ Gingiva؛ Matrix Metalloproteinase-8؛ Saliva
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