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Ahmadi, Mehran, Mahrooz, Abdolkarim, Abediankenari, Saeid, Hayati Roodbari, Nasim. (1399). Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 17(3), 215-225. doi: 10.22034/iji.2020.85513.1715
Mehran Ahmadi; Abdolkarim Mahrooz; Saeid Abediankenari; Nasim Hayati Roodbari. "Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes". سامانه مدیریت نشریات علمی, 17, 3, 1399, 215-225. doi: 10.22034/iji.2020.85513.1715
Ahmadi, Mehran, Mahrooz, Abdolkarim, Abediankenari, Saeid, Hayati Roodbari, Nasim. (1399). 'Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes', سامانه مدیریت نشریات علمی, 17(3), pp. 215-225. doi: 10.22034/iji.2020.85513.1715
Ahmadi, Mehran, Mahrooz, Abdolkarim, Abediankenari, Saeid, Hayati Roodbari, Nasim. Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1399; 17(3): 215-225. doi: 10.22034/iji.2020.85513.1715

Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes

Iranian Journal of Immunology
دوره 17، شماره 3، آذر 2020، صفحه 215-225    اصل مقاله (729.54 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2020.85513.1715
نویسندگان
Mehran Ahmadi1؛ Abdolkarim Mahrooz* 2؛ Saeid Abediankenari3؛ Nasim Hayati Roodbari4
1Department of Biochemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Immunogenetics Research Center, Mazandaran University Of medical Sciences, Sari, IRAN
4Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
Background: Functional single nucleotide polymorphisms in zinc transporter 8 (ZnT8) gene may be key determinants of humoral autoreactivity to ZnT8. Objective: The present study is expected to provide new information on the association of rs11558471 in ZnT8 gene with IL-17 levels and insulin resistance in an Iranian population [a high-risk population for type 2 diabetes (T2D)]. Methods: A total of 133 patients with T2D and 128 control subjects were included. Insulin and IL-17 concentrations were determined using ELISA. Insulin and fasting glucose levels were used to determine homeostasis model assessment for insulin resistance (HOMA-IR). The genetic analyses were performed by the restricted fragment length polymorphism (RFLP) after PCR amplification. Results: The risk allele frequency of rs11558471 in this Iranian population was among the highest in different populations. In T2D patients, compared with the GG genotypes, IL-17 concentrations were significantly higher in the GA+AA group (p= 0.042). According to the genotypes of this SNP, IL-17 concentrations, fasting glucose and HOMA-IR increased with the following order:GG
کلیدواژه‌ها
IL-17؛ Insulin Resistance؛ rs11558471؛ SLC30A8؛ Type 2 Diabetes
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