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IL-6 and IL-10 Closely Correlate with Bacterial Bloodstream Infection | ||
Iranian Journal of Immunology | ||
دوره 17، شماره 3، آذر 2020، صفحه 185-203 اصل مقاله (1.49 M) | ||
نوع مقاله: Original Article | ||
شناسه دیجیتال (DOI): 10.22034/iji.2020.87266.1793 | ||
نویسندگان | ||
Jingjing Guan1؛ Zhongyong Wang1؛ Xiaoyuan Liu2؛ Yujie Jiang1؛ Qiuqi Gao3؛ Qing Wu1؛ Hong Lu1؛ Lianfeng Wu1؛ Zhuo Zhang1؛ Xiangyang Lin* 1؛ Jingjing Qian1 | ||
1Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China | ||
2School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325000, China | ||
3Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China | ||
چکیده | ||
Background: Given the high mortality of bacterial bloodstream infections (BSI), blood culture results do not meet clinical needs timely due to being time-consuming and having low positive rate. Whether we can identify the severity and type of bacterial infections by cytokines is a controversial issue. Objective: To investigate the dynamic change of cytokines in BSI. Methods: 55 patients with Gram-positive (GP) BSI, 64 patients with Gram-negative (GN) BSI and 52 healthy controls were enrolled. We quantitatively detected the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) by flow cytometry in the sera. The levels of procalcitonin, C-reactive protein, leukocytes and neutrophils were also detected simultaneously. Results: There were significantly up-regulated IL-6 and IL-10 expression in BSI patients, particularly in the GN-BSI, for instance Escherichia coli and Klebsiella pneumoniae infections; following the treatment, IL-6 and IL-10 decreased by 10-23 and 4-27 times, respectively. Additionally, IL-2, TNF-α and IFN-γ expression increased slightly in BSI patients and IFN-γ expression declined as GN-BSI progressed. Conclusion: IL-6 and IL-10 are closely associated with the severity and treatment efficacy of BSI, and can help to distinguish between GP-BSI and GN-BSI at an early stage. | ||
کلیدواژهها | ||
Bloodstream Infection؛ Cytokines؛ Gram-Negative Bacteria؛ IL-6؛ IL-10 | ||
آمار تعداد مشاهده مقاله: 1,542 تعداد دریافت فایل اصل مقاله: 1,127 |