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Arefpour, A M, Bahrami, M, Haghparast, A, Khoshgard, K, Aryaei Tabar, H, Farshchian, N. (1399). Evaluating Dose-response of Cataract Induction in Radiotherapy of Head and Neck Cancers Patients. سامانه مدیریت نشریات علمی, 11(1), 9-16. doi: 10.31661/jbpe.v0i0.834
A M Arefpour; M Bahrami; A Haghparast; K Khoshgard; H Aryaei Tabar; N Farshchian. "Evaluating Dose-response of Cataract Induction in Radiotherapy of Head and Neck Cancers Patients". سامانه مدیریت نشریات علمی, 11, 1, 1399, 9-16. doi: 10.31661/jbpe.v0i0.834
Arefpour, A M, Bahrami, M, Haghparast, A, Khoshgard, K, Aryaei Tabar, H, Farshchian, N. (1399). 'Evaluating Dose-response of Cataract Induction in Radiotherapy of Head and Neck Cancers Patients', سامانه مدیریت نشریات علمی, 11(1), pp. 9-16. doi: 10.31661/jbpe.v0i0.834
Arefpour, A M, Bahrami, M, Haghparast, A, Khoshgard, K, Aryaei Tabar, H, Farshchian, N. Evaluating Dose-response of Cataract Induction in Radiotherapy of Head and Neck Cancers Patients. سامانه مدیریت نشریات علمی, 1399; 11(1): 9-16. doi: 10.31661/jbpe.v0i0.834

Evaluating Dose-response of Cataract Induction in Radiotherapy of Head and Neck Cancers Patients

Journal of Biomedical Physics and Engineering
مقاله 2، دوره 11، شماره 1، اردیبهشت 2021، صفحه 9-16    اصل مقاله (749.62 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.834
نویسندگان
A M Arefpour1؛ M Bahrami2؛ A Haghparast* 3؛ K Khoshgard3؛ H Aryaei Tabar4؛ N Farshchian5
1MD, Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2MSc, Department of Medical Physics, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3PhD, Department of Medical Physics, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4MD, Departments of Ophthalmology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
5MD, Department of Radiation Oncology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background: Head and neck cancers are currently the most common types of cancers. 3D-conformal radiation therapy is the most common dose delivery technique for head and neck cancers. Eye Lens is a radio sensitive structure and cataract formation as a visual disorder associated with exposure to ionizing radiation which is documented.
Objective: Determining the radiation dose to eye lens during head and neck radiography and estimating the probability of cataract induction are essential.
Material and Methods: This experimental study was performed on 14 patients with head and neck cancers through experimental study analysis. The maximum opacity of the eyes lens were measured by pentacamTM before radiation therapy. CT data of patients were transmitted to Isogray treatment planning Software, and dose calculations for each patient was performed. At the end of radiation treatment, 3 and 6 months after radiotherapy, the eye lens opacity of the patients was assessed.
Results: Overall, 28 lenses were studied. Statistical one sample K- S test proved normality of obtained data. Using repeated measures test, the relation before and 3 months after radiotherapy, as well as the relationship before and 6 months after radiotherapy proved a significant relationship.
Conclusion: The opacity caused by radiation in eyes is a non-statistical and linear-quadratic response curve with no threshold. This opacity can also appear within 3 months after completion of radiation therapy.
کلیدواژه‌ها
Head and Neck Cancers؛ Radiotherapy؛ Cataract؛ Eye Lens Absorbed Dose؛ Radiation Dosage
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