LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,142
تعداد مقالات10,465
تعداد مشاهده مقاله44,839,197
تعداد دریافت فایل اصل مقاله10,694,396
Divband, B, Gharehaghaji, N, Takhiri, M. (1399). Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles. سامانه مدیریت نشریات علمی, 10(5), 589-596. doi: 10.31661/jbpe.v0i0.2008-1165
B Divband; N Gharehaghaji; M Takhiri. "Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles". سامانه مدیریت نشریات علمی, 10, 5, 1399, 589-596. doi: 10.31661/jbpe.v0i0.2008-1165
Divband, B, Gharehaghaji, N, Takhiri, M. (1399). 'Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles', سامانه مدیریت نشریات علمی, 10(5), pp. 589-596. doi: 10.31661/jbpe.v0i0.2008-1165
Divband, B, Gharehaghaji, N, Takhiri, M. Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles. سامانه مدیریت نشریات علمی, 1399; 10(5): 589-596. doi: 10.31661/jbpe.v0i0.2008-1165

Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles

Journal of Biomedical Physics and Engineering
مقاله 8، دوره 10، شماره 5، دی 2020، صفحه 589-596    اصل مقاله (1.02 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2008-1165
نویسندگان
B Divband1، 2، 3؛ N Gharehaghaji* 4؛ M Takhiri5، 6
1PhD, Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, Iran
2PhD, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3PhD, Inorganic Chemistry Department, Chemistry Faculty, University of Tabriz, C.P. 51664 Tabriz, Iran
4PhD, Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
5MSc, Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
6MSc, Medical Imaging Center, Emam Reza Hospital, Iranian Social Security Organization, Urmia, Iran
چکیده
Background: Gadolinium oxide nanoparticles as positive contrast material of magnetic resonance imaging (MRI) have attracted a great attention due to the appropriate magnetic properties. One of the most desirable features of these nanoparticles is their ability of doping with other lanthanides which can change their properties.
Objective: This study aimed to investigate the effect of neodymium doping on MRI relaxivity of the gadolinium oxide nanoparticles.
Material and Methods: In this experimental study, the oleic acid coated gadolinium oxide nanoparticles and the neodymium doped nanoparticles were prepared by polymer pyrolysis method. X-ray diffraction test and scanning electron microscopy were used for characterization of the particles. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to investigate the in vitro cell toxicity of the nanoparticles. The r1 and r2 relaxivities were extracted from the T1 and T2 weighted MR images, respectively.
Results: The average size of the cytocompatible spherical-like shape nanoparticles was 40 nm. The neodymium doped nanoparticles produced a significant decrease in the r1 relaxivity, and a 1.7 fold increase in the r2 relaxivity compared to the gadolinium oxide nanoparticles.
Conclusion: Doping of neodymium into the gadolinium oxide nanoparticles suppresses the r1 relaxivity and enhances the r2 relaxivity of the nanoparticles.
کلیدواژه‌ها
Relaxivity؛ Magnetic Resonance Imaging؛ Doping؛ Gadolinium Oxide؛ Nanoparticles؛ Neodymium
سایر فایل های مرتبط با مقاله
مراجع
  1. Coran A, Ortolan P, Attar S, Alberioli E, Perissinotto E, Tosi AL, et al. Magnetic resonance imaging assessment of lipomatous soft-tissue tumors. In Vivo. 2017;31(3):387-95. doi: 10.21873/invivo.11071. PubMed PMID: 28438867. PubMed PMCID: PMC5461449.
  2. Cao Y, Xu L, Kuang Y, Xiong D, Pei R. Gadolinium-based nanoscale MRI contrast agents for tumor imaging. J Mater Chem B. 2017;5(19):3431-61. doi: 10.1039/c7tb00382j. PubMed PMID: 32264282.
  3. Boehm-Sturm P, Haeckel A, Hauptmann R, Mueller S, Kuhl CK, Schellenberger EA. Low molecular-weight iron chelates may be an alternative to gadolinium-based contrast agents for T1-weighted contrast-enhanced MR imaging. Radiology. 2017;286(2):537-46. doi: 10.1148/radiol.2017170116. PubMed PMID: 28880786.
  4. Mishra SK, Kannan S. Doxorubicin-conjugated bimetallic silver–gadolinium nanoalloy for multimodal MRI-CT-optical imaging and pH-responsive drug release. ACS Biomater Sci Eng. 2017;3:3607-19. doi: 10.1021/acsbiomaterials.7b00498.
  5. Ghaderi S, Divband B, Gharehaghaji N. Magnetic resonance imaging property of doxorubicin-loaded gadolinium/13X zeolite/folic acid nanocomposite. J Biomed Phys Eng. 2020;10(1):103-10. doi: 10.31661/jbpe.v0i0.1254. PubMed PMID: 32158717. PubMed PMCID: PMC7036414.
  6. Zhang G, Gao J, Qian J, Zhang L, Zheng K, Zhong K, et al. Hydroxylated mesoporous nanosilica coated by polyethylenimine coupled with gadolinium and folic acid: a tumor-targeted T1 magnetic resonance contrast agent and drug delivery system. ACS Appl Mater Interfaces. 2015;7(26):14192-200. doi: 10.1021/acsami.5b04294. PubMed PMID: 26084052.
  7. Ni D, Bu W, Ehlerding EB, Cai W, Shi J. Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents. Chem Soc Rev. 2017;46(23):7438-68. doi: 10.1039/c7cs00316a. PubMed PMID: 29071327. PubMed PMCID: PMC5705441.
  8. Chowdhury MA. Metal-organic-frameworks for biomedical applications in drug delivery, and as MRI contrast agents. J Biomed Mater Res A. 2017;105(4):1184-94. doi: 10.1002/jbm.a.35995. PubMed PMID: 28033653.
  9. Ahmad MY, Ahmad MW, Cha H, Oh IT, Tegafaw T, Miao X, et al. Cyclic RGD-coated ultrasmall Gd2O3 nanoparticles as tumor-targeting positive magnetic resonance imaging contrast agents. Eur J Inorg Chem. 2018;2018:3070-9. doi: 10.1002/ejic.201800023.
  10. Dutta RK, Pandey AC. Fluorescent magnetic gadolinium oxide nanoparticles for biomedical applications. Nanosci Technol. 2015;2:1-6. doi: 10.15226/2374-8141/2/2/00130.
  11. Cho M, Sethi R, Lee SS, Benoit DN, Taheri N, Decuzzi P, et al. Gadolinium oxide nanoplates with high longitudinal relaxivity for magnetic resonance imaging. Nanoscale. 2014;6:13637-45. doi: 10.1039/c4nr03505d.
  12. Ranjan SK, Dey R, Soni AK, Rai VK. Er3+-Tm3+-Yb3+: Gd2O3 upconverting phosphors for sensing and laser-induced heating applications. IEEE Sens J. 2016;16:8494-500. doi: 10.1109/JSEN.2016.2609139.
  13. Chen F, Chen M, Yang C, Liu J, Luo N, Yang G, et al. Terbium-doped gadolinium oxide nanoparticles prepared by laser ablation in liquid for use as a fluorescence and magnetic resonance imaging dual-modal contrast agent. Phys Chem Chem Phys. 2015;17(2):1189-96. doi: 10.1039/c4cp04380d. PubMed PMID: 25418675.
  14. Liu J, Tian X, Luo N, Yang C, Xiao J, Shao Y, et al. Sub-10 nm monoclinic Gd2O3: Eu3+ nanoparticles as dual-modal nanoprobes for magnetic resonance and fluorescence imaging. Langmuir. 2014;30:13005-13. doi: 10.1021/la503228v.
  15. Deng H, Chen F, Yang C, Chen M, Li L, Chen D. Effect of Eu doping concentration on fluorescence and magnetic resonance imaging properties of Gd2O3: Eu3+ nanoparticles used as dual-modal contrast agent. Nanotechnology. 2018;29:415601. doi: 10.1088/1361-6528/aad347.
  16. Shi HZ, Li L, Zhang LY, Wang TT, Wang CG, Su ZM. Facile fabrication of hollow mesoporous Eu3+-doped Gd2O3 nanoparticles for dual-modal imaging and drug delivery. Dyes Pigments. 2015;123:8-15. doi: 10.1016/j.dyepig.2015.07.015.
  17. Lu YR, Gou MY, Zhang LY, Li L, Wang TT, Wang CG, et al. Facile one-pot synthesis of hollow mesoporous fluorescent Gd2O3: Eu/calcium phosphate nanospheres for simultaneous dual-modal imaging and pH-responsive drug delivery. Dyes Pigments. 2017;147:514-22. doi: 10.1016/j.dyepig.2017.08.043.
  18. Kuo T, Lai W, Li C, Wun Y, Chang H, Chen J, et al. AS1411 aptamer-conjugated Gd2O3: Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging. Nano Res. 2014;7:658-69. doi: 10.1007/s12274-014-0420-4.
  19. Li H, Song S, Wang W, Chen K. In vitro photodynamic therapy based on magnetic-luminescent Gd2O3: Yb, Er nanoparticles with bright three-photon up-conversion fluorescence under near-infrared light. Dalton Trans. 2015;44:16081-90. doi: 10.1039/c5dt01015b.
  20. Liu J, Huang L, Tian X, Chen X, Shao Y, Xie F, et al. Magnetic and fluorescent Gd2O3: Yb3+/Ln3+ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy. Int J Nanomedicine. 2017;12:1-14. doi: 10.2147/IJN.S118938. PubMed PMID: 28031709. PubMed PMCID: PMC5179219.
  21. Boopathi G, Raj SG, Kumar GR, Mohan R. Structural and optical properties of Nd3+ doped gadolinium oxide 1D nanorods. AIP Conf Proc. 2014;1591:44-5. doi: 10.1063/1.4872483.
  22. Khatamian M, Khandar AA, Divband B, Haghighi M, Ebrahimiasl S. Hetrogeneous photocatalytice degradation of 4-nitrophenol in aqueous suspension by Ln (La3+,Nd3+,Sm3+) doped ZnO nanoparticles. J Mol Catal A Chem. 2012;365:120-7. doi: 10.1016/j.molcata.2012.08.018.
  23. Zeini M, Divband B, Khezerloo D, Gharehaghaji N. Biointerface Research in Applied Chemistry. Biointerface Res Appl Chem. 2019;9(4):4101-6. doi: 10.33263/BRIAC94.101106.
  24. Kim CR, Baeck JS, Chang Y, Bae JE, Chae KS, Lee GH. Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field. Phys Chem Chem Phys. 2014;16:19866-73. doi: 10.1039/c4cp01946f.
  25. Tegafaw T, Xu W, Lee SH, Chae KS, Cha H, Chang Y, et al. Ligand-size and ligand-chain hydrophilicity effects on the relaxometric properties of ultrasmall Gd2O3 nanoparticles. AIP Adv. 2016;6:065114. doi: 10.1063/1.4954182.
  26. Luo N, Yang C, Tian X, Xiao J, Liu J, Chen F, et al. A general top-down approach to synthesize rare earth doped- Gd2O3 nanocrystals as dualmodal contrast agents. J Mater Chem B. 2014;2:5891-7. doi: 10.1039/C4TB00695J.
آمار
تعداد مشاهده مقاله: 1,599
تعداد دریافت فایل اصل مقاله: 555


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب