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Farshad, Omid, Ommati, Mohammad Mehdi, Yuzugulen, Jale, Alizadeh, Sahand, Mousavi, Khadijeh, Azarpira, Negar, Marhonian, Anahita, Jamshidzadeh, Akram, Heidari, Reza. (1399). Skeletal Muscle Mitochondrial Impairment in Cirrhosis-Induced Sarcopenia. سامانه مدیریت نشریات علمی, 6(3), 189-204. doi: 10.30476/tips.2020.87789.1067
Omid Farshad; Mohammad Mehdi Ommati; Jale Yuzugulen; Sahand Alizadeh; Khadijeh Mousavi; Negar Azarpira; Anahita Marhonian; Akram Jamshidzadeh; Reza Heidari. "Skeletal Muscle Mitochondrial Impairment in Cirrhosis-Induced Sarcopenia". سامانه مدیریت نشریات علمی, 6, 3, 1399, 189-204. doi: 10.30476/tips.2020.87789.1067
Farshad, Omid, Ommati, Mohammad Mehdi, Yuzugulen, Jale, Alizadeh, Sahand, Mousavi, Khadijeh, Azarpira, Negar, Marhonian, Anahita, Jamshidzadeh, Akram, Heidari, Reza. (1399). 'Skeletal Muscle Mitochondrial Impairment in Cirrhosis-Induced Sarcopenia', سامانه مدیریت نشریات علمی, 6(3), pp. 189-204. doi: 10.30476/tips.2020.87789.1067
Farshad, Omid, Ommati, Mohammad Mehdi, Yuzugulen, Jale, Alizadeh, Sahand, Mousavi, Khadijeh, Azarpira, Negar, Marhonian, Anahita, Jamshidzadeh, Akram, Heidari, Reza. Skeletal Muscle Mitochondrial Impairment in Cirrhosis-Induced Sarcopenia. سامانه مدیریت نشریات علمی, 1399; 6(3): 189-204. doi: 10.30476/tips.2020.87789.1067

Skeletal Muscle Mitochondrial Impairment in Cirrhosis-Induced Sarcopenia

Trends in Pharmaceutical Sciences
مقاله 5، دوره 6، شماره 3، آذر 2020، صفحه 189-204    اصل مقاله (1.01 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2020.87789.1067
نویسندگان
Omid Farshad1؛ Mohammad Mehdi Ommati2؛ Jale Yuzugulen3؛ Sahand Alizadeh3؛ Khadijeh Mousavi1؛ Negar Azarpira4؛ Anahita Marhonian5؛ Akram Jamshidzadeh5؛ Reza Heidari* 6
1Pharmaceutical Sciences Research Center, Shiraz university of Medical Sciences, Shiraz, Iran
2College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi 030801, Peoples’ Republic of China
3Eastern Mediterranean University, Faculty of Pharmacy, Famagusta, North Cyprus, Turkey
4Transplant Research Center, Shiraz University of Medical Sciences
5Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
6Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center
چکیده
Cirrhosis-associated muscle mass loss or sarcopenia is a common complication (17-30% prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly understood. Therefore, finding the mechanisms of sarcopenia could lead to the development of therapeutic strategies against this complication. In the current study, rats underwent bile duct ligation (BDL) surgery, and their skeletal muscle (gastrocnemius; GS) was isolated and assessed 28 and 56 days after BDL operation. Significant increase in biomarkers of oxidative stress, including reactive oxygen species (ROS) formation, lipid peroxidation, and increased oxidized glutathione (GSSG) levels were detected in the muscle of cirrhotic animals. Skeletal muscle tissue antioxidant capacity and reduced glutathione (GSH) were also significantly decreased in BDL rats. Moreover, deterioration of several mitochondrial indices, including mitochondrial depolarization, increased mitochondrial permeabilization, depleted ATP reservoirs, and decreased mitochondrial dehydrogenases activity, were evident in the GS isolated from cirrhotic rats. Based on these data, oxidative stress and mitochondrial impairment seem to play as primary mechanisms of cirrhosis-induced sarcopenia.
کلیدواژه‌ها
Cell death؛ Cirrhosis؛ Energy crisis؛ Mitochondria؛ Muscle waste؛ Weakness
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