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Odeghe, Bensandy, Adikwu, Elias, John, Frances. (1399). Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice. سامانه مدیریت نشریات علمی, 6(4), 271-278. doi: 10.30476/tips.2020.87005.1054
Bensandy Othuke Odeghe; Elias Adikwu; Frances Ebubechi John. "Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice". سامانه مدیریت نشریات علمی, 6, 4, 1399, 271-278. doi: 10.30476/tips.2020.87005.1054
Odeghe, Bensandy, Adikwu, Elias, John, Frances. (1399). 'Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice', سامانه مدیریت نشریات علمی, 6(4), pp. 271-278. doi: 10.30476/tips.2020.87005.1054
Odeghe, Bensandy, Adikwu, Elias, John, Frances. Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice. سامانه مدیریت نشریات علمی, 1399; 6(4): 271-278. doi: 10.30476/tips.2020.87005.1054

Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice

Trends in Pharmaceutical Sciences
مقاله 6، دوره 6، شماره 4، اسفند 2020، صفحه 271-278    اصل مقاله (602.74 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2020.87005.1054
نویسندگان
Bensandy Othuke Odeghe* 1؛ Elias Adikwu2؛ Frances Ebubechi John1
1Department of Biochemistry, Faculty of Science, Madonna University Nigeria
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Nigeria
چکیده
Challenges including treatment failure, cost, resistance, and adverse effects associated with antimalarial drugs have increased the use of medical plants as alternative treatment. Anchomanes difformis (A. difformis) is a multipurpose plant used traditionally for the treatment of a variety of ailments including malaria, but with a paucity of scientific evidence. This study assessed the antiplasmodial activity of A. difformis aqueous leaf extract (AEA) in Plasmodium berghei (P. berghei) infected mice. AEA (100, 200 and 400 mg/kg) was orally administered to P. berghei infected mice in the curative, suppressive and prophylactic groups. The untreated parasitized control (UPC) and the positive control were administered orally with normal saline (0.2mL) and chloroquine (CQ) (10mg/kg). After treatment, blood samples were analyzed for parasitamia level, hematological parameters and liver samples were evaluated for histology. Curative, suppressive and prophylactic studies showed that administered AEA decreased parasitamia levels and increased survival time in a dose-dependent fashion with significance at 200 mg/kg (p
کلیدواژه‌ها
Anchomanes difformis؛ Antimalaria؛ Hematology؛ Liver؛ Mice
مراجع
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