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Zafari, Venus, Shanehbandi, Dariush, Bornehdeli, Soghra, Sadeghzadeh, Mahsa, Zarredar, Habib, Asadi, Milad, Sharifi, Akbar. (1399). MicroRNA Profiling in Non-Small Cell Lung Cancer and its Implications for the Disease Pathogenesis. سامانه مدیریت نشریات علمی, 12(1), 79-85. doi: 10.30476/mejc.2020.83348.1156
Venus Zafari; Dariush Shanehbandi; Soghra Bornehdeli; Mahsa Sadeghzadeh; Habib Zarredar; Milad Asadi; Akbar Sharifi. "MicroRNA Profiling in Non-Small Cell Lung Cancer and its Implications for the Disease Pathogenesis". سامانه مدیریت نشریات علمی, 12, 1, 1399, 79-85. doi: 10.30476/mejc.2020.83348.1156
Zafari, Venus, Shanehbandi, Dariush, Bornehdeli, Soghra, Sadeghzadeh, Mahsa, Zarredar, Habib, Asadi, Milad, Sharifi, Akbar. (1399). 'MicroRNA Profiling in Non-Small Cell Lung Cancer and its Implications for the Disease Pathogenesis', سامانه مدیریت نشریات علمی, 12(1), pp. 79-85. doi: 10.30476/mejc.2020.83348.1156
Zafari, Venus, Shanehbandi, Dariush, Bornehdeli, Soghra, Sadeghzadeh, Mahsa, Zarredar, Habib, Asadi, Milad, Sharifi, Akbar. MicroRNA Profiling in Non-Small Cell Lung Cancer and its Implications for the Disease Pathogenesis. سامانه مدیریت نشریات علمی, 1399; 12(1): 79-85. doi: 10.30476/mejc.2020.83348.1156

MicroRNA Profiling in Non-Small Cell Lung Cancer and its Implications for the Disease Pathogenesis

Middle East Journal of Cancer
مقاله 8، دوره 12، شماره 1 - شماره پیاپی 45، فروردین 2021، صفحه 79-85    اصل مقاله (458.58 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.83348.1156
نویسندگان
Venus Zafari1؛ Dariush Shanehbandi2؛ Soghra Bornehdeli1؛ Mahsa Sadeghzadeh1؛ Habib Zarredar1؛ Milad Asadi1؛ Akbar Sharifi* 1
1Department of Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Lung cancer is one of the most common cancers worldwide. Despite the progression in screening and diagnostic methods, the prevalence and mortality rates of this cancer have not decreased in recent decades. Recent evidence has implied the possible roles of miR-212, miR-124a, miR-125b, miR-27a, and miR-133b in carcinogenesis process. Hence, we examined the changes in the expression level of these microRNAs (miRNAs) during carcinogenesis determined the possible application of these factors as diagnostic or prognostic biomarkers for non-small cell lung cancer (NSCLC).
Method: 50 NSCLC patients participated in this descriptive case-control study. During bronchoscopy, we collected their tumor and adjacent normal tumor-free tissues. We further extracted the total RNA from the cells, synthetized cDNA, and examined the expression level of target miRNAs by quantitative real-time PCR. Subsequently, we analyzed the expression levels of these genes and their correlation with clinicopathologic features of patients.
Results: The output data of our study showed a statistically significant deregulation in miR-212 (P= 0.002), miR-124a (P=0.001), miR-125b (P= 0.023), miR-27a (P=0.012), and miR-133b (P= 0.05). Moreover, the expression levels of these miRNAs had significant correlations with metastasis, lymph node involvement, tumor cell differentiation degree, and tumor size of NSCLC patients.
Conclusion: All of the studied miRNAs could potentially be used as diagnostic or prognostic biomarkers.
کلیدواژه‌ها
Carcinoma؛ Non-small-cell lung؛ MicroRNA؛ Biomarker
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How to cite this article:

Zafari V, Shanehbandi D, Bornehdeli S, Sadeghzadeh M, Zarredar H, Asadi M, et al. MicroRNA profiling in non-small cell lung cancer and its implications for the disease pathogenesis. Middle East J Cancer.2021; 12(1):79-85. doi:10.30476/mejc. 2020.83348.1156.

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