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An Investigation of the Pathology Report of Prostate Cancer Patients with Radical Prostatectomy in Southern Iran: A Cross-sectional Study | ||
| Middle East Journal of Cancer | ||
| مقاله 7، دوره 12، شماره 1 - شماره پیاپی 45، فروردین 2021، صفحه 69-78 اصل مقاله (800 K) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2020.82414.1088 | ||
| نویسندگان | ||
| Ali Ariafar1، 2؛ Shahryar Zeighami1، 2؛ Mehdi Salehipour1، 2؛ Faisal Ahmed* 1، 3؛ Zahra Shahabi1؛ Hossein-Ali Nikbakht4 | ||
| 1Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Urology Oncology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Department of Urology, School of Medicine, Ibb University of Medical Sciences, Ibb, Yemen | ||
| 4Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran | ||
| چکیده | ||
| Background: Prostate cancer is a major malignancy worldwide among men; it is the fourth leading cancer in both genders. This study investigated the pathologic factors of radical prostatectomy (RP) specimens. Method: About 578 men underwent RP during five years in Shiraz University hospitals. We recorded the following clincopathological parameters: tumor type and stage, Gleason score (GS), grade, tertiary pattern, ISUP, surgical margin, lymph node (LN) involvement, lymphovascular invasion, seminal vesicle involvement, extraprostatic extension (EPE), vas deferens invasion, perineural and pseudocapsular invasion, bladder neck involvement, and age. Results: The mean age of participants was 63.87 ± 6.95 years. Most had pathologic T2N0Mx (73 %) diseases; the most GS was low-risk GS ≤ 6 (47.4%). Surgical margin status was free of tumors in 72.5% and among those with positive margins; the most involved site was the apex in 18.3%. Single and dual LN involvements were the most prevalent patterns. 5.9% of the patients had EPE. We found perineural and pseudocapsular invasions in 59.9% and 29.9%, respectively. There was a strong correlation between the clincopathological parameters, stage, and ISUP. Perineural invasion, pseudocapsular invasion, and tertiary pattern 5 increased with advanced age (P < 0.0001). The GS 8 to 10 increased with the increase in age (P =0.001). Conclusion: A strong correlation existed between the clincopathological parameters, stage, and ISUP. Additionally, perineural and pseudocapsular involvement and tertiary pattern 5 had a strong relationship with advanced age. | ||
| کلیدواژه‌ها | ||
| Prostate cancer؛ Radical prostatectomy؛ Pathology | ||
| اصل مقاله | ||
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How to cite this article: Ariafar A, Zeighami S, Salehipour M, Ahmed F, Shahabi Z, Nikbakht HA. An investigation of the pathology report of prostate cancer patients with radical prostatectomy in southern Iran: A cross-sectional study. Middle East J Cancer. 2021;12(1):69-78. doi: 10.30476/mejc.2020. 82414.1088. | ||
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