LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,113
تعداد مقالات10,208
تعداد مشاهده مقاله40,771,317
تعداد دریافت فایل اصل مقاله8,800,454
Omar, Wesam, Ahmed, Amr E., Raslan, Mai, El-Nesr, Khalid, Ali, Mamdouh, De Abdelmaksoud, Mohamed, El Dahshan, Dina. (1399). Effect of Lutein-Rich Extract on Human Cancer Cells. سامانه مدیریت نشریات علمی, 12(1), 147-150. doi: 10.30476/mejc.2020.82181.1063
Wesam Mostafa Omar; Amr E. Ahmed; Mai Raslan; Khalid El-Nesr; Mamdouh Moawad Ali; Mohamed De Abdelmaksoud; Dina El Dahshan. "Effect of Lutein-Rich Extract on Human Cancer Cells". سامانه مدیریت نشریات علمی, 12, 1, 1399, 147-150. doi: 10.30476/mejc.2020.82181.1063
Omar, Wesam, Ahmed, Amr E., Raslan, Mai, El-Nesr, Khalid, Ali, Mamdouh, De Abdelmaksoud, Mohamed, El Dahshan, Dina. (1399). 'Effect of Lutein-Rich Extract on Human Cancer Cells', سامانه مدیریت نشریات علمی, 12(1), pp. 147-150. doi: 10.30476/mejc.2020.82181.1063
Omar, Wesam, Ahmed, Amr E., Raslan, Mai, El-Nesr, Khalid, Ali, Mamdouh, De Abdelmaksoud, Mohamed, El Dahshan, Dina. Effect of Lutein-Rich Extract on Human Cancer Cells. سامانه مدیریت نشریات علمی, 1399; 12(1): 147-150. doi: 10.30476/mejc.2020.82181.1063

Effect of Lutein-Rich Extract on Human Cancer Cells

Middle East Journal of Cancer
مقاله 47، دوره 12، شماره 1 - شماره پیاپی 45، فروردین 2021، صفحه 147-150    اصل مقاله (116.67 K)
نوع مقاله: Brief Report(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.82181.1063
نویسندگان
Wesam Mostafa Omar1؛ Amr E. Ahmed1؛ Mai Raslan1؛ Khalid El-Nesr2؛ Mamdouh Moawad Ali3؛ Mohamed De Abdelmaksoud3؛ Dina El Dahshan* 4
1Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt
2Pathology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt
3Biochemistry Department, National Research Centre, Cairo, Egypt
4Clinical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
چکیده
Background: Lutein and its isomerzeaxanthin are safe natural compounds. They are able to reduce the development of tumor and other chronic diseases. The objectives of the current study was to examine the cytotoxicity of lutein isolated and purified from alfalfa, safe and low-cost plant, on five different human cancer cell lines, namely (MCF-7), (HepG2), (A549), (PC3), and (HCT116), as well as normal (HFB4) cells.
Method: We examined the cytotoxicity of lutein purified from Medicago sativa L and evaluate its activity against human liver HepG2, breast MCF-7, lung A549, prostate PC3, and colon HCT116 cancer cell lines using SRB assay in comparison with doxorubicin as a reference drug.
Results: Results revealed that the tested extract could be a more promising anticancer agent in the case of MCF-7 (IC50, 3.10±0.47 μg/ml) compared with standard drug doxorubicin (IC50, 2.90±0.30 μg/ml). Moreover, the extract showed a moderate effect on HepG2 (IC50, 6.11±0.84 μg/ml) versus doxorubicin (IC50, 2.90±0.30 μg/ml); meanwhile, the extract showed no activity against A549, PC3, and HCT116 cells. The results further revealed that the extract had no toxicity against the growth of normal HFB4 cells versus doxorubicin.
Conclusion: Lutein-rich extract from alfalfa had a major antiproliferative role in breast MCF-7 and liver HepG2 compared to doxorubicin.
کلیدواژه‌ها
Carotenoids؛ Medicago sativa L؛ Alfalfa؛ Cytotoxicity؛ Anticancer
اصل مقاله

How to cite this article:

Omar WM, Ahmed , Raslan M, El-Nesr K, Ali MM, Abdelmaksoud DM, et al. Effect of lutein-rich extract on human cancer cells. Middle East J Cancer. 2021; 12(1):147-50. doi:10.30476/ mejc. 2020.82181.1063.

آمار
تعداد مشاهده مقاله: 6,154
تعداد دریافت فایل اصل مقاله: 6,353


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب