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Chan, Wai, Hamid, Marlina Tanty Ramli, Westerhout, Caroline Judy, Tze, Tan, Pailoor, Jayalakshmi, Rahmat, Kartini. (1399). Multimodality Imaging Features of Breast Carcinoma in Women with Neurofibromatosis Type 1 (NF 1) – A Report of Two Cases. سامانه مدیریت نشریات علمی, 12(1), 151-159. doi: 10.30476/mejc.2020.81924.1053
Wai Yee Chan; Marlina Tanty Ramli Hamid; Caroline Judy Westerhout; Tan Ling Tze; Jayalakshmi Pailoor; Kartini Rahmat. "Multimodality Imaging Features of Breast Carcinoma in Women with Neurofibromatosis Type 1 (NF 1) – A Report of Two Cases". سامانه مدیریت نشریات علمی, 12, 1, 1399, 151-159. doi: 10.30476/mejc.2020.81924.1053
Chan, Wai, Hamid, Marlina Tanty Ramli, Westerhout, Caroline Judy, Tze, Tan, Pailoor, Jayalakshmi, Rahmat, Kartini. (1399). 'Multimodality Imaging Features of Breast Carcinoma in Women with Neurofibromatosis Type 1 (NF 1) – A Report of Two Cases', سامانه مدیریت نشریات علمی, 12(1), pp. 151-159. doi: 10.30476/mejc.2020.81924.1053
Chan, Wai, Hamid, Marlina Tanty Ramli, Westerhout, Caroline Judy, Tze, Tan, Pailoor, Jayalakshmi, Rahmat, Kartini. Multimodality Imaging Features of Breast Carcinoma in Women with Neurofibromatosis Type 1 (NF 1) – A Report of Two Cases. سامانه مدیریت نشریات علمی, 1399; 12(1): 151-159. doi: 10.30476/mejc.2020.81924.1053

Multimodality Imaging Features of Breast Carcinoma in Women with Neurofibromatosis Type 1 (NF 1) – A Report of Two Cases

Middle East Journal of Cancer
مقاله 48، دوره 12، شماره 1 - شماره پیاپی 45، فروردین 2021، صفحه 151-159    اصل مقاله (3.31 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.81924.1053
نویسندگان
Wai Yee Chan1؛ Marlina Tanty Ramli Hamid* 2؛ Caroline Judy Westerhout1؛ Tan Ling Tze1؛ Jayalakshmi Pailoor3؛ Kartini Rahmat1
1Department of Biomedical Imaging, University Malaya Research Imaging Center, University of Malaya, Kuala Lumpur, Malaysia
2Department of Radiology, Faculty of Medicine, University Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia
3Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
چکیده
With a prevalence of approximately 1 out of 2,500 to 4,000 births, neurofibromatosis type 1 (NF1), also known as von Recklinghausen’s disease, is one of the most prevalent autosomal dominant diseases in humans. There is four to five-fold increased risk of malignancy in these patients due to the presence of NF1 gene mutation, which is a tumour suppressor inhibiting RAS activation. NF1 is known to be closely associated with central nervous system (CNS) tumours; however, its association with other non-CNS malignancies is not uncommon. Mutation of BRCA1 (breast cancer 1, early onset) and BRCA2 (breast cancer 2, susceptibility protein) genes has long been recognized as an important risk factor for the develpoment of breast cancer. Incidentally, BRCA1 and NF1 genes are both located in the long arm of chromosome 17. The association between NF1 and breast cancer has long been debated; recent studies, on the other hand, have established this association, with NF1 unequivocally identified as breast cancer susceptibility gene conferring a moderate risk of breast cancer development. In this report, we described multimodality imaging features of breast cancer in two women with NF1; we further reviewed the literatures on the association between NF1 and breast cancer and its diagnostic challenge.
کلیدواژه‌ها
Neurofibromatosis type 1؛ Breast cancer؛ Risk factor؛ MRI
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How to cite this article:

Chan WY, Ramli Hamid MT, Westerhout CJ, Pailoor J, Rahmat K. Multimodality imaging features of breast carcinoma in women with neurofibromatosis type 1 (NF 1) – A report of two cases. Middle East J Cancer. 2021;12(1):151-9. doi: 10.30476/mejc.2020. 81924.1053.

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