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Safaei, Akbar, Jansar, Elham, Monabati, Ahmad, Mokhtari, Maral, Montazer, Mehdi. (1399). SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review. سامانه مدیریت نشریات علمی, 11(4), 476-482. doi: 10.30476/mejc.2020.82264.1073
Akbar Safaei; Elham Jansar; Ahmad Monabati; Maral Mokhtari; Mehdi Montazer. "SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review". سامانه مدیریت نشریات علمی, 11, 4, 1399, 476-482. doi: 10.30476/mejc.2020.82264.1073
Safaei, Akbar, Jansar, Elham, Monabati, Ahmad, Mokhtari, Maral, Montazer, Mehdi. (1399). 'SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review', سامانه مدیریت نشریات علمی, 11(4), pp. 476-482. doi: 10.30476/mejc.2020.82264.1073
Safaei, Akbar, Jansar, Elham, Monabati, Ahmad, Mokhtari, Maral, Montazer, Mehdi. SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review. سامانه مدیریت نشریات علمی, 1399; 11(4): 476-482. doi: 10.30476/mejc.2020.82264.1073

SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review

Middle East Journal of Cancer
مقاله 11، دوره 11، شماره 4 - شماره پیاپی 44، دی 2020، صفحه 476-482    اصل مقاله (3.58 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2020.82264.1073
نویسندگان
Akbar Safaei؛ Elham Jansar؛ Ahmad Monabati؛ Maral Mokhtari؛ Mehdi Montazer*
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Synovial sarcoma is an aggressive soft tissue sarcoma. It has a wide spectrum of histopathologic patterns and uncertain immunohistochemistry, rendering it a diagnostic challenge. The objective of this study was to investigate the diagnostic utility and impact of SS18-SSX rearrangement evaluation in an Iranian population previously diagnosed with synovial sarcoma without such molecular tests.
Method: We conducted this cross-sectional study on 44 formalin-fixed paraffin-embedded tissue blocks obtained from 23 synovial sarcoma patients (males, 69%; mean age, 36.4 years) and 11 cases with other neoplasms as negative controls. We assessed these specimens for SSX-SS18 gene rearrangement by break-apart fluorescent in situ hybridization (FISH) probes.
Results: FISH study showed SS18-SSX fusion gene in 17 (73.91%) cases while six (26.09%) cases and negative controls did not show SS18-SSX fusion. Histopathologic type of tumor was significantly related to the presence of rearrangement (P=0.002) (rearranged: 11 biphasic and six monophasic tumors; non-rearranged: three monophasic and three poorly-differentiated tumors).
Conclusion: This study supports the idea that molecular studies contribute to the confirmation of synovial sarcoma diagnosis, particularly in monophasic and poorly-differentiated subtypes, which show vague immunohistochemical results.
کلیدواژه‌ها
Synovial sarcoma؛ Gene fusion؛ Fluorescent in situ hybridization؛ SS18-SSX1 fusion protein
اصل مقاله

How to cite this article:

Safaei A, Jansar E, Monabati A, Mokhtari M, Montazer M. SS18-SSX rearrangement in synovial sarcoma using fluorescent in situ hybridization: A report from an Iranian population and literature review. Middle East J Cancer. 2020;11(4): 476-82. doi: 10.30476/mejc. 2020.82264.1073.

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