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Samsami, Alamtaj, Ghasempour, Leila, Moradi, Shaghayegh, Davoodi, Sara, rahmati, Jamshid, Karimian, Ali, Tavasoli, Mona. (1399). Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study. سامانه مدیریت نشریات علمی, 8(4), 305-310. doi: 10.30476/ijcbnm.2020.84255.1207
Alamtaj Samsami; Leila Ghasempour; Shaghayegh Moradi; Sara Davoodi; Jamshid rahmati; Ali Karimian; Mona Tavasoli. "Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study". سامانه مدیریت نشریات علمی, 8, 4, 1399, 305-310. doi: 10.30476/ijcbnm.2020.84255.1207
Samsami, Alamtaj, Ghasempour, Leila, Moradi, Shaghayegh, Davoodi, Sara, rahmati, Jamshid, Karimian, Ali, Tavasoli, Mona. (1399). 'Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study', سامانه مدیریت نشریات علمی, 8(4), pp. 305-310. doi: 10.30476/ijcbnm.2020.84255.1207
Samsami, Alamtaj, Ghasempour, Leila, Moradi, Shaghayegh, Davoodi, Sara, rahmati, Jamshid, Karimian, Ali, Tavasoli, Mona. Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study. سامانه مدیریت نشریات علمی, 1399; 8(4): 305-310. doi: 10.30476/ijcbnm.2020.84255.1207

Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study

International Journal of Community Based Nursing & Midwifery
مقاله 3، دوره 8، شماره 4 - شماره پیاپی 32، دی 2020، صفحه 305-310    اصل مقاله (330.84 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijcbnm.2020.84255.1207
نویسندگان
Alamtaj Samsami1؛ Leila Ghasempour1؛ Shaghayegh Moradi1؛ Sara Davoodi* 1؛ Jamshid rahmati2؛ Ali Karimian3؛ Mona Tavasoli1
1Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
2Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
3Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Autoimmune diseases are a main cause of primary ovarian insufficiency. This study was designed to elucidate the relationship between ovarian reserve and anti-thyroid peroxidase antibodies in women of different ages.
Methods: 98 women in a cross-sectional study was conducted at the infertility Center of Shiraz University of Medical Sciences, Hazrate Zeinab Hospital, from September 2018 to March 2019. Women with infertility and thyroid-stimulating hormone (TSH) > 3mIU/L were included in the study with convenience sampling. Data were collected by a form containing demographic characteristics, thyroid hormones, and ovarian reserve data. Participants were categorized based on the negative or positive anti-thyroid peroxidase (anti-TPO) antibodies. According to a pilot sample, and possible dropout of 20%, the sample size was determined to be 49 cases in each group. The results were compared between groups using SPSS, version 22. All statistical comparisons were performed using the t-test, and the data are presented as the mean±SD. P-values less than 0.05 were considered significant.
Results: 49 women were analyzed in each group. There was no significant difference between the groups in the mean age (P=0.42), body mass index (BMI) (P=0.34), duration of infertility (P=0.99), mean prolactin (P=0.66), TSH (P=0.17), thyroxine (T4) (P=0.87) and follicle-stimulating hormone (FSH) levels (P=0.14). Ovarian reserve characteristics: antral follicular count (AFC) and anti-Müllerian hormone (AMH) levels in anti-TPO positive group were 10.61±7.29 and 1.98±2.38, respectively, and AFC and AMH in anti- TPO negative group were 16.46±6.38 and 2.94±2.22, respectively. There were significant differences between the two groups on AFC (P <0.001) and AMH (P=0.04).
Conclusion: Patients with autoimmune thyroiditis were at higher risk for decreased ovarian reserve. They should consider their lower reproductive life span during their childbearing years.
کلیدواژه‌ها
Female infertility؛ Hashimoto disease؛ Anti-Müllerian hormone؛ Ovarian reserve
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مراجع
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