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Fetuin A and Interleukin 8 in Children with Clinical Remission of Type 1 Diabetes | ||
| Iranian Journal of Immunology | ||
| مقاله 5، دوره 17، شماره 2، شهریور 2020، صفحه 144-153 اصل مقاله (602.53 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2020.82797.1595 | ||
| نویسندگان | ||
| Aleksandra Pyziak-Skupien1؛ Katarzyna Bobeff2؛ Krystyna Wyka2؛ Katarzyna Banach2؛ Beata Malachowska3؛ Wojciech Fendler4؛ Agnieszka Szadkowska5؛ Wojciech Mlynarski2؛ Agnieszka Zmyslowska* 6 | ||
| 1Department of Pediatrics, Silesian Medical University in Katowice, Katowice, Poland | ||
| 2Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Poland | ||
| 3Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland | ||
| 4Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA | ||
| 5Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Poland | ||
| 6Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland | ||
| چکیده | ||
| Background: Clinical partial remission (CPR) in most patients with type 1 diabetes (T1D) is observed shortly after clinical diagnosis. Increasing body weight and impaired insulin sensitivity may play a role in the pathogenesis of CPR. Several cytokines can also participate in the development of insulin resistance. Objective:To evaluate the relationship between birth weight, body mass index, and the concentrations of IL-8 and Fetuin-A, and the presence of clinical partial remission in children at the T1D onset. Methods:The study group consisted of 134 children with a newly diagnosed T1D in whom the presence of CPR was evaluated in a further 2-year course of diabetes. The control group included 47 children withoutglucose tolerance disorders. The concentrations of IL-8 and Fetuin-A were determined by the ELISA method. Results: CPR occurred in 75.34% of T1D patients. At T1D onset, higher values of BMI SDS in the remitters as compared to the patients without remission were observed. At the T1D onset, the concentrations of Fetuin-A (p=0.031) and IL-8 (p=0.042) were significantly higher in patients compared to those without CPR. Conclusion: Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR. | ||
| کلیدواژه‌ها | ||
| BMI؛ Diabetes Type 1؛ Fetuin A؛ Interleukin 8؛ Remission | ||
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آمار تعداد مشاهده مقاله: 918 تعداد دریافت فایل اصل مقاله: 557 |
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