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Gheisari, Rasoul, Arasteh, Peyman, Estakhri, Firuzeh, Eatemadi, Hesamoddin, Jamshidi, Aida, Khoshnoud, Mohammad Javad, Mokhtari, Maral. (1399). The Safety and Side Effects of Amide-Based Local Anesthetics in Rats with Acetaminophen-Induced Hepatic Injury. سامانه مدیریت نشریات علمی, 45(5), 377-382. doi: 10.30476/ijms.2020.72596.0
Rasoul Gheisari; Peyman Arasteh; Firuzeh Estakhri; Hesamoddin Eatemadi; Aida Jamshidi; Mohammad Javad Khoshnoud; Maral Mokhtari. "The Safety and Side Effects of Amide-Based Local Anesthetics in Rats with Acetaminophen-Induced Hepatic Injury". سامانه مدیریت نشریات علمی, 45, 5, 1399, 377-382. doi: 10.30476/ijms.2020.72596.0
Gheisari, Rasoul, Arasteh, Peyman, Estakhri, Firuzeh, Eatemadi, Hesamoddin, Jamshidi, Aida, Khoshnoud, Mohammad Javad, Mokhtari, Maral. (1399). 'The Safety and Side Effects of Amide-Based Local Anesthetics in Rats with Acetaminophen-Induced Hepatic Injury', سامانه مدیریت نشریات علمی, 45(5), pp. 377-382. doi: 10.30476/ijms.2020.72596.0
Gheisari, Rasoul, Arasteh, Peyman, Estakhri, Firuzeh, Eatemadi, Hesamoddin, Jamshidi, Aida, Khoshnoud, Mohammad Javad, Mokhtari, Maral. The Safety and Side Effects of Amide-Based Local Anesthetics in Rats with Acetaminophen-Induced Hepatic Injury. سامانه مدیریت نشریات علمی, 1399; 45(5): 377-382. doi: 10.30476/ijms.2020.72596.0

The Safety and Side Effects of Amide-Based Local Anesthetics in Rats with Acetaminophen-Induced Hepatic Injury

Iranian Journal of Medical Sciences
مقاله 8، دوره 45، شماره 5، آذر 2020، صفحه 377-382    اصل مقاله (242.05 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.72596.0
نویسندگان
Rasoul Gheisari1؛ Peyman Arasteh* 2؛ Firuzeh Estakhri3؛ Hesamoddin Eatemadi1؛ Aida Jamshidi4؛ Mohammad Javad Khoshnoud5؛ Maral Mokhtari6
1Department of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Student Research Committee, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Toxicology and Pharmacology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The use of amide-based local anesthetics is generally considered to be safe. However, the literature on their safety in patients with hepatic injury is scarce. For the first time, the present study aimed to evaluate the effect and safety of five commonly used amide-based local anesthetics in the setting of hepatic failure.
Methods: A total of 96 Sprague-Dawley rats were studied from September 2015 to September 2016 in the Animal Laboratory Center, Shiraz University of Medical Sciences, Shiraz, Iran. They divided into three groups, namely a control, induced liver failure (LF), and non-LF groups. The rats were administered local anesthetic agents (lidocaine, prilocaine with felypressin, lidocaine with epinephrine, mepivacaine, articaine, and prilocaine). The effect of these drugs was evaluated by comparing the liver enzyme levels of the rats. The data were analyzed using SPSS software. The independent t test, one-way ANOVA, and the post hoc tests were used to compare groups. A p Results: In non-LF rats, mepivacaine, lidocaine, and lidocaine with epinephrine caused a significant increase in aspartate aminotransferase (AST) level compared with the effect of prilocaine with felypressin and articaine. In non-LF rats, only mepivacaine resulted in a significant increase in AST level compared with lidocaine (P=0.007) and prilocaine with felypressin (P=0.044). In this group, only mepivacaine caused a significant increase in alanine transaminase (ALT) level compared with lidocaine (P=0.016). Whereas in the LF group, mepivacaine caused an increase in ALT level compared with the effect of both prilocaine with felypressin (P=0.009) and articaine (p <0.001). The use of mepivacaine in the LF group caused a significant increase in gamma-glutamyl transpeptidase level compared prilocaine with felypressin (P=0.039).
Conclusion: Articaine and prilocaine with felypressin local anesthetics induced the least change in hepatic enzyme levels in rats with abnormal hepatic function.
کلیدواژه‌ها
Anesthetics؛ Local drug-related side effects and adverse reactions؛ Safety؛ Liver failure؛ Rats, Sprague-Dawley
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