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Kadkhodaee, Mehri, Seifi, Behjat, Ranjbaran, Mina, Shams, Sedigheh, Delavari, Fatemeh, Najafi, Atefeh, Sedaghat, Zahra, Khastar, Hossein. (1399). The Impact of Sex Differences on Renal Protective Effects of Lipopolysaccharide Preconditioning in Septic Shock. سامانه مدیریت نشریات علمی, 45(5), 383-390. doi: 10.30476/ijms.2020.72461.0
Mehri Kadkhodaee; Behjat Seifi; Mina Ranjbaran; Sedigheh Shams; Fatemeh Delavari; Atefeh Najafi; Zahra Sedaghat; Hossein Khastar. "The Impact of Sex Differences on Renal Protective Effects of Lipopolysaccharide Preconditioning in Septic Shock". سامانه مدیریت نشریات علمی, 45, 5, 1399, 383-390. doi: 10.30476/ijms.2020.72461.0
Kadkhodaee, Mehri, Seifi, Behjat, Ranjbaran, Mina, Shams, Sedigheh, Delavari, Fatemeh, Najafi, Atefeh, Sedaghat, Zahra, Khastar, Hossein. (1399). 'The Impact of Sex Differences on Renal Protective Effects of Lipopolysaccharide Preconditioning in Septic Shock', سامانه مدیریت نشریات علمی, 45(5), pp. 383-390. doi: 10.30476/ijms.2020.72461.0
Kadkhodaee, Mehri, Seifi, Behjat, Ranjbaran, Mina, Shams, Sedigheh, Delavari, Fatemeh, Najafi, Atefeh, Sedaghat, Zahra, Khastar, Hossein. The Impact of Sex Differences on Renal Protective Effects of Lipopolysaccharide Preconditioning in Septic Shock. سامانه مدیریت نشریات علمی, 1399; 45(5): 383-390. doi: 10.30476/ijms.2020.72461.0

The Impact of Sex Differences on Renal Protective Effects of Lipopolysaccharide Preconditioning in Septic Shock

Iranian Journal of Medical Sciences
مقاله 9، دوره 45، شماره 5، آذر 2020، صفحه 383-390    اصل مقاله (2.53 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2020.72461.0
نویسندگان
Mehri Kadkhodaee* 1؛ Behjat Seifi1؛ Mina Ranjbaran1؛ Sedigheh Shams2؛ Fatemeh Delavari1؛ Atefeh Najafi3؛ Zahra Sedaghat4؛ Hossein Khastar5
1Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran
3Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Department of Physiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5Department of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
چکیده
Background: Induction of septic shock by lipopolysaccharide (LPS) may lead to acute renal failure. The present study aimed to investigate the impact of sex differences on the effectiveness of low-dose LPS preconditioning (LPS-PC) on LPS-induced acute renal failure in rats.
Methods: This study was conducted at Tehran University of Medical Sciences, in 2017. A total of 48 Wistar rats were equally divided into two groups of male and female rats. The rats in each group were then allocated to three groups (n=8 per group), namely control, septic shock, and LPS-PC group. A high dose of LPS was administered for septic shock induction. LPS-PC was induced by injecting LPS before sepsis induction. The effect of sex differences on renal functional indices, renal oxidative stress markers, plasma tumor necrosis factor-α level, and renal histological changes was evaluated. Data were analyzed using two-way ANOVA followed by Tukey’s post hoc test.
Results: In the septic shock groups, renal functional parameters (creatinine [Cr] and blood urea nitrogen [BUN]) were increased in both sexes. However, the increase was more significant in male rats (male rats: Cr=2.14±0.13, BUN=81±4.15; female rats: Cr=1.64±0.12, BUN=50±2.7). LPS-PC reduced these indices in both sexes (male rats: Cr=1.24±0.03, BUN=57±4.1; female rats: Cr=0.86±0.02, BUN=30.31±2.25). Renal superoxide dismutase (SOD) activity (male rats: 11.54±1.34, female rats: 24.4±2.04) and catalase (CAT) activity (male rats: 15±1.74, female rats: 25.75±1.97) were significantly higher in the female septic group. LPS-PC significantly increased SOD (male rats: 25.7±2.45, female rats: 42.6±3.31) and CAT (male rats: 37.25±2.34, female rats: 59.21±3.29) activities in renal tissue samples in the LPS-PC group in both sexes compared to the septic groups. In the LPS groups, plasma tumor necrosis factor-α (male rats: 375±25.65, female rats: 285.45±25.94) were significantly higher than in the LPS-PC groups (male rats: 250±21.35, female rats: 121±24.14).
Conclusion: Male rats were more susceptible to sepsis-induced renal damage. LPS-PC had protective effects on the LPS-induced renal injury, and these effects were most prominent in female rats.
کلیدواژه‌ها
Renal؛ Sex differences؛ Septic shock؛ Lipopolysaccharides
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